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Q1C931

- BETB_YERPA

UniProt

Q1C931 - BETB_YERPA

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Protein
NAD/NADP-dependent betaine aldehyde dehydrogenase
Gene
betB, YPA_1074
Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid By similarity.UniRule annotation

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

Binds 2 potassium ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi93 – 931Potassium 1 By similarity
Active sitei162 – 1621Charge relay system By similarity
Metal bindingi180 – 1801Potassium 1; via carbonyl oxygen By similarity
Binding sitei209 – 2091NAD/NADP; via amide nitrogen By similarity
Metal bindingi246 – 2461Potassium 2; via carbonyl oxygen By similarity
Sitei248 – 2481Seems to be a necessary countercharge to the potassium cations By similarity
Active sitei252 – 2521Proton acceptor By similarity
Binding sitei286 – 2861NAD/NADP By similarity
Binding sitei387 – 3871NAD/NADP By similarity
Metal bindingi457 – 4571Potassium 2; via carbonyl oxygen By similarity
Metal bindingi460 – 4601Potassium 2; via carbonyl oxygen By similarity
Active sitei464 – 4641Charge relay system By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi150 – 1534NAD/NADP By similarity
Nucleotide bindingi176 – 1794NAD/NADP By similarity
Nucleotide bindingi229 – 2346NAD/NADP By similarity

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, NADP, Potassium

Enzyme and pathway databases

BioCyciYPES360102:GHZU-1113-MONOMER.
UniPathwayiUPA00529; UER00386.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betB
Ordered Locus Names:YPA_1074
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001971: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation
PRO_1000047061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei286 – 2861Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Dimer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi360102.YPA_1074.

Structurei

3D structure databases

ProteinModelPortaliQ1C931.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
KOiK00130.
OMAiCTDEMTI.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00804. BADH.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01804. BADH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1C931-1 [UniParc]FASTAAdd to Basket

« Hide

MSRYGLQKLY INGAYTDSTS GDTFDAVNPA NGECIAQLQA ANAQDVDKAV    50
AAAKQGQPVW AAMTAMERSR ILRRAVDILR DRNDELAAIE TADTGKPLSE 100
TRSVDIVTGA DVLEYYAGLI PALEGQQIPL RGSAFVYTRR EPLGVVAGIG 150
AWNYPLQIAL WKSAPALAAG NAMIFKPSEV TSLTALKLAG IYTEAGLPAG 200
VFNVLTGSGD QVGQMLTEHP GIAKVSFTGG IASGKKVMAN AAGSTLKDVT 250
MELGGKSPLI IFADADLDKA ADIAMMANFY SSGQVCTNGT RVFVPQALQA 300
AFEQKIVERV KRIHIGDPSD ERTNFGPLVS FQHRDSVMRY IDSGKREGAT 350
LLIGGYSLTE GALAHGAYVA PTVFTHCRDD MQIVREEIFG PVMSILSYQS 400
EEEVIRRAND TEYGLAAGVV TQDLNRAHRV IHQLQAGICW INTWGESAPE 450
MPVGGYKHSG VGRENGISTL EHYTQIKSIQ VELGSFNSVF 490
Length:490
Mass (Da):52,596
Last modified:July 11, 2006 - v1
Checksum:iF44CCA7CEE56F0B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000308 Genomic DNA. Translation: ABG13041.1.
RefSeqiYP_650986.1. NC_008150.1.

Genome annotation databases

EnsemblBacteriaiABG13041; ABG13041; YPA_1074.
GeneIDi4121109.
KEGGiypa:YPA_1074.
PATRICi18581286. VBIYerPes1796_1467.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000308 Genomic DNA. Translation: ABG13041.1 .
RefSeqi YP_650986.1. NC_008150.1.

3D structure databases

ProteinModelPortali Q1C931.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360102.YPA_1074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG13041 ; ABG13041 ; YPA_1074 .
GeneIDi 4121109.
KEGGi ypa:YPA_1074.
PATRICi 18581286. VBIYerPes1796_1467.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
KOi K00130.
OMAi CTDEMTI.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00386 .
BioCyci YPES360102:GHZU-1113-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_00804. BADH.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR011264. BADH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01804. BADH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Antiqua.

Entry informationi

Entry nameiBETB_YERPA
AccessioniPrimary (citable) accession number: Q1C931
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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