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Protein

NAD(P)H dehydrogenase (quinone)

Gene

YPA_1236

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12NAD(P)UniRule annotation1
Binding sitei51NAD(P); via carbonyl oxygenUniRule annotation1
Binding sitei99SubstrateUniRule annotation1
Binding sitei134FMNUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 14FMNUniRule annotation5
Nucleotide bindingi111 – 162FMNUniRule annotationAdd BLAST52

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandFlavoprotein, FMN, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPES360102:GHZU-1276-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase (quinone)UniRule annotation (EC:1.6.5.2UniRule annotation)
Alternative name(s):
Flavoprotein WrbA
NAD(P)H:quinone oxidoreductaseUniRule annotation
Short name:
NQOUniRule annotation
Gene namesi
Ordered Locus Names:YPA_1236
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
Proteomesi
  • UP000001971 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002910371 – 199NAD(P)H dehydrogenase (quinone)Add BLAST199

Structurei

3D structure databases

ProteinModelPortaliQ1C8L9.
SMRiQ1C8L9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 190Flavodoxin-likeUniRule annotationAdd BLAST187

Sequence similaritiesi

Belongs to the WrbA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000030539.
KOiK03809.
OMAiDWADAYL.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR. 1 hit.
InterProiView protein in InterPro
IPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
PfamiView protein in Pfam
PF03358. FMN_red. 1 hit.
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiView protein in PROSITE
PS50902. FLAVODOXIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1C8L9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKILVLYYS MYGHIETLAG AIAEGARKVS GVDVTIKRVP ETMPAEAFAK
60 70 80 90 100
AGGKTNQQAP VATPHELADY DGIIFGTPTR FGNMSGQMRT FLDQTGGLWA
110 120 130 140 150
SGALYGKVAS VFASTGTGGG QEHTITSTWT TLAHHGFIIV PIGYGAKELF
160 170 180 190
DVSQTRGGTP YGATTIAGGD GSRQPSAEEL AIARFQGEHV AKITAKLKG
Length:199
Mass (Da):20,808
Last modified:July 11, 2006 - v1
Checksum:i1CA884408B326512
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG13203.1.
RefSeqiWP_002211168.1. NZ_CP009906.1.

Genome annotation databases

EnsemblBacteriaiABG13203; ABG13203; YPA_1236.
KEGGiypa:YPA_1236.
PATRICi18581664. VBIYerPes1796_1655.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG13203.1.
RefSeqiWP_002211168.1. NZ_CP009906.1.

3D structure databases

ProteinModelPortaliQ1C8L9.
SMRiQ1C8L9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG13203; ABG13203; YPA_1236.
KEGGiypa:YPA_1236.
PATRICi18581664. VBIYerPes1796_1655.

Phylogenomic databases

HOGENOMiHOG000030539.
KOiK03809.
OMAiDWADAYL.

Enzyme and pathway databases

BioCyciYPES360102:GHZU-1276-MONOMER.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR. 1 hit.
InterProiView protein in InterPro
IPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
PfamiView protein in Pfam
PF03358. FMN_red. 1 hit.
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiView protein in PROSITE
PS50902. FLAVODOXIN_LIKE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNQOR_YERPA
AccessioniPrimary (citable) accession number: Q1C8L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: July 11, 2006
Last modified: March 15, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.