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Q1C6R0

- NAGK_YERPA

UniProt

Q1C6R0 - NAGK_YERPA

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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.By similarity

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincBy similarity
Metal bindingi177 – 1771ZincBy similarity
Metal bindingi179 – 1791ZincBy similarity
Metal bindingi184 – 1841ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPSequence Analysis
Nucleotide bindingi133 – 1408ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. N-acetylglucosamine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. peptidoglycan turnover Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciYPES360102:GHZU-1946-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinase (EC:2.7.1.59)
Alternative name(s):
GlcNAc kinase
Gene namesi
Name:nagK
Ordered Locus Names:YPA_1896
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001971: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256N-acetyl-D-glucosamine kinasePRO_0000270124Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360102.YPA_1896.

Structurei

3D structure databases

ProteinModelPortaliQ1C6R0.
SMRiQ1C6R0. Positions 1-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.Curated

Phylogenomic databases

eggNOGiCOG1940.
HOGENOMiHOG000150087.
KOiK00884.
OMAiEMPKRIP.
OrthoDBiEOG61P6P0.

Family and domain databases

InterProiIPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1C6R0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYYGFDMGGT KIELGVFDEN LQRIWHKRVP TPREDYPQLL QILRDLTEEA
60 70 80 90 100
DTYCGVQGSV GIGIPGLPNA DDGTVFTANV PSAMGQPLQA DLSRLIQREV
110 120 130 140 150
RIDNDANCFA LSEAWDPEFR TYPTVLGLIL GTGVGGGLIV NGSIVSGRNH
160 170 180 190 200
ITGEFGHFRL PVDALDILGA DIPRVPCGCG HRGCIENYIS GRGFEWMYSH
210 220 230 240 250
FYQHTLPATD IIAHYAAGEP KAVAHVERFM DVLAVCLGNL LTMLGSPFGR

GGWGVV
Length:256
Mass (Da):27,879
Last modified:July 11, 2006 - v1
Checksum:i0BCE117500ABD548
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000308 Genomic DNA. Translation: ABG13862.1.
RefSeqiYP_651807.1. NC_008150.1.

Genome annotation databases

EnsemblBacteriaiABG13862; ABG13862; YPA_1896.
GeneIDi4122400.
KEGGiypa:YPA_1896.
PATRICi18583192. VBIYerPes1796_2412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000308 Genomic DNA. Translation: ABG13862.1 .
RefSeqi YP_651807.1. NC_008150.1.

3D structure databases

ProteinModelPortali Q1C6R0.
SMRi Q1C6R0. Positions 1-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360102.YPA_1896.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG13862 ; ABG13862 ; YPA_1896 .
GeneIDi 4122400.
KEGGi ypa:YPA_1896.
PATRICi 18583192. VBIYerPes1796_2412.

Phylogenomic databases

eggNOGi COG1940.
HOGENOMi HOG000150087.
KOi K00884.
OMAi EMPKRIP.
OrthoDBi EOG61P6P0.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci YPES360102:GHZU-1946-MONOMER.

Family and domain databases

InterProi IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Antiqua.

Entry informationi

Entry nameiNAGK_YERPA
AccessioniPrimary (citable) accession number: Q1C6R0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: July 11, 2006
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Might be inactive, since the sequence is shorter than in other family members, due to a probable natural frameshift in the C-terminus.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3