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Protein

Trans-aconitate 2-methyltransferase

Gene

tam

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + trans-aconitate = S-adenosyl-L-homocysteine + (E)-3-(methoxycarbonyl)pent-2-enedioate.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYPES360102:GHZU-2051-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Trans-aconitate 2-methyltransferaseUniRule annotation (EC:2.1.1.144UniRule annotation)
Gene namesi
Name:tamUniRule annotation
Ordered Locus Names:YPA_2001
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000001971 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Trans-aconitate 2-methyltransferasePRO_1000056586Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1C6F5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. Tam family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000125295.
KOiK00598.
OMAiARVDVWR.
OrthoDBiEOG6716PV.

Family and domain databases

Gene3Di1.10.150.290. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans.
InterProiIPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1C6F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDWDPDLYR QFEAERTRPA TDLLAHITIT SPQFISDLGC GPGNSTELLH
60 70 80 90 100
RRFPDAQLVG IDHSQAMLAS AQQRLPHCTF IEADIHQWRP SQPQNLIYAN
110 120 130 140 150
ASLQWLTDHP HLFPSLLSQL APRGVLAVQM PDNLDQPSHR AMREVAENGP
160 170 180 190 200
WQQTLQEAGA TRAKVLSANH YYDLLAPHAE RVDIWRTTYY HPMPSAQAIV
210 220 230 240 250
DWLRATGLRP YLAPLTEAMQ LAFLQNYLAI IDKAYPARTD GRRLLAFPRL

FIVAHAQR
Length:258
Mass (Da):29,353
Last modified:July 11, 2006 - v1
Checksum:i875672BF8CA0281F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG13967.1.
RefSeqiWP_002210232.1. NZ_CP009906.1.

Genome annotation databases

EnsemblBacteriaiABG13967; ABG13967; YPA_2001.
KEGGiypa:YPA_2001.
PATRICi18583426. VBIYerPes1796_2529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG13967.1.
RefSeqiWP_002210232.1. NZ_CP009906.1.

3D structure databases

ProteinModelPortaliQ1C6F5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG13967; ABG13967; YPA_2001.
KEGGiypa:YPA_2001.
PATRICi18583426. VBIYerPes1796_2529.

Phylogenomic databases

HOGENOMiHOG000125295.
KOiK00598.
OMAiARVDVWR.
OrthoDBiEOG6716PV.

Enzyme and pathway databases

BioCyciYPES360102:GHZU-2051-MONOMER.

Family and domain databases

Gene3Di1.10.150.290. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00560. Tran_acon_Me_trans.
InterProiIPR029063. SAM-dependent_MTases.
IPR023506. Trans-aconitate_MeTrfase.
IPR023149. Trans_acon_MeTrfase_C.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Antiqua.

Entry informationi

Entry nameiTAM_YERPA
AccessioniPrimary (citable) accession number: Q1C6F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: November 11, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.