Q1C5H7 (PEPB_YERPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidase B
EC=3.4.11.23

Alternative name(s):
Aminopeptidase B

Gene names

Name:	pepB
Ordered Locus Names:	YPA_2330

Organism

Yersinia pestis bv. Antiqua (strain Antiqua) [Complete proteome] [HAMAP]

Taxonomic identifier

360102 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Yersinia › Yersinia pestis

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probably plays an important role in intracellular peptide degradation By similarity. HAMAP-Rule MF_00504
Catalytic activity	Release of an N-terminal amino acid, Xaa, from a peptide or arylamide. Xaa is preferably Glu or Asp but may be other amino acids, including Leu, Met, His, Cys and Gln. HAMAP-Rule MF_00504
Cofactor	Binds 2 manganese ions per subunit By similarity.
Subunit structure	Homohexamer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase M17 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: HAMAP metalloexopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Peptidase B HAMAP-Rule MF_00504		PRO_0000258500
Sites
	Active site	208	1	Potential
	Active site	282	1	Potential
	Metal binding	196	1	Manganese 2 By similarity
	Metal binding	201	1	Manganese 1 By similarity
	Metal binding	201	1	Manganese 2 By similarity
	Metal binding	219	1	Manganese 2 By similarity
	Metal binding	278	1	Manganese 1 By similarity
	Metal binding	280	1	Manganese 1 By similarity
	Metal binding	280	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1C5H7 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 57FDBB6B4DB67F2D	FASTA	432	46,531
	10 20 30 40 50 60 MTTEIMQISL SHNPADARWG EKALISTNDQ GVTIHLTSHD QLGGIQRAAR KIDGQGIKQV 70 80 90 100 110 120 KLAGEGWGLE QSWAFWQGFR GPKGQRSVVW AELPANEKTE LEQRLKIIDW VRDTINAPAE 130 140 150 160 170 180 DLGPEQLAKN AIDLLCAVSC DAVSYRITKG EDLREQNYAG IYTVGRGSDR APVLLALDYN 190 200 210 220 230 240 PTGNPDAPVM ACLVGKGITF DSGGYSLKQS AFMDSMKSDM GGAATLTGAL ALAAARGLKE 250 260 270 280 290 300 RVKLYLCCAD NMVSGNAFKL GDIIRYRNGK TVEIMNTDAE GRLVLADGLI DASEQNAPLI 310 320 330 340 350 360 IDAATLTGAA KTALGNDYHA LFSFDDELAQ ALLNSAHSEH ELFWRLPLAE FHRSQLPSNF 370 380 390 400 410 420 AELNNVAGGA YSAGASTAAA FLSHFVKNYQ QGWLHIDCSA TYRKSAVDQW SAGATGLGVR 430 TVANLLLAQA KQ

References

[1]

"Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen." Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L. J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Antiqua.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000308 Genomic DNA. Translation: ABG14295.1.
RefSeq	YP_652240.1. NC_008150.1.
3D structure databases
ProteinModelPortal	Q1C5H7.
ModBase	Search...
Protein-protein interaction databases
STRING	360102.YPA_2330.
Proteomic databases
PRIDE	Q1C5H7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG14295; ABG14295; YPA_2330.
GeneID	4121210.
KEGG	ypa:YPA_2330.
PATRIC	18584214. VBIYerPes1796_2918.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0260.
HOGENOM	HOG000243130.
KO	K07751.
OMA	KLAGDGW.
ProtClustDB	PRK05015.
Family and domain databases
HAMAP	MF_00504. Aminopeptidase_M17.
InterPro	IPR011356. Leucine_aapep/pepB. IPR008330. Pept_M17_PepB. IPR000819. Peptidase_M17_C. [Graphical view]
PANTHER	PTHR11963:SF3. PTHR11963:SF3. 1 hit.
Pfam	PF12404. DUF3663. 1 hit. PF00883. Peptidase_M17. 1 hit. [Graphical view]
PIRSF	PIRSF036388. Ctsl_amnpptdse_B. 1 hit.
PRINTS	PR00481. LAMNOPPTDASE.
PROSITE	PS00631. CYTOSOL_AP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PEPB_YERPA

Accession

Primary (citable) accession number: Q1C5H7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 11, 2006
Last modified:	May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program