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Protein

Xanthine phosphoribosyltransferase

Gene

gpt

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Acts on guanine, xanthine and to a lesser extent hypoxanthine.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (gpt), Xanthine phosphoribosyltransferase (gpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 6915-phosphoribose 1-diphosphateUniRule annotation
Metal bindingi89 – 891MagnesiumUniRule annotation
Binding sitei92 – 921XanthineUniRule annotation
Binding sitei135 – 1351Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciYPES360102:GHZU-2778-MONOMER.
UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Alternative name(s):
Xanthine-guanine phosphoribosyltransferaseUniRule annotation
Short name:
XGPRTUniRule annotation
Gene namesi
Name:gptUniRule annotation
Ordered Locus Names:YPA_2717
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
Proteomesi
  • UP000001971 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 152152Xanthine phosphoribosyltransferasePRO_0000261023Add
BLAST

Proteomic databases

PRIDEiQ1C4E3.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1C4E3.
SMRiQ1C4E3. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 3825-phosphoribose 1-diphosphate bindingUniRule annotation
Regioni92 – 9655-phosphoribose 1-diphosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226805.
KOiK00769.
OMAiKAHFATV.
OrthoDBiEOG6H1Q23.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01903. XGPRT.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023747. Xanthine_Guanine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1C4E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEKYVVTWD MLQIHARKLA QRLLPAEQWK GIIAVSRGGL VPAGILAREL
60 70 80 90 100
GIRYVDTVCI SSYDHDNQRD LKVLKRAEGD GEGFIVIDDL VDTGGTATAI
110 120 130 140 150
REMYPKAHFV TIFAKPAGRP LVDDYVVDIP QNTWIEQPWD MAVTFVAPLS

GK
Length:152
Mass (Da):16,966
Last modified:July 11, 2006 - v1
Checksum:iFACA8D10E3A76A94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG14679.1.
RefSeqiWP_002208704.1. NZ_CP009906.1.

Genome annotation databases

EnsemblBacteriaiABG14679; ABG14679; YPA_2717.
KEGGiypa:YPA_2717.
PATRICi18585113. VBIYerPes1796_3360.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG14679.1.
RefSeqiWP_002208704.1. NZ_CP009906.1.

3D structure databases

ProteinModelPortaliQ1C4E3.
SMRiQ1C4E3. Positions 3-152.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ1C4E3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG14679; ABG14679; YPA_2717.
KEGGiypa:YPA_2717.
PATRICi18585113. VBIYerPes1796_3360.

Phylogenomic databases

HOGENOMiHOG000226805.
KOiK00769.
OMAiKAHFATV.
OrthoDBiEOG6H1Q23.

Enzyme and pathway databases

UniPathwayiUPA00602; UER00658.
BioCyciYPES360102:GHZU-2778-MONOMER.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01903. XGPRT.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023747. Xanthine_Guanine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Antiqua.

Entry informationi

Entry nameiXGPT_YERPA
AccessioniPrimary (citable) accession number: Q1C4E3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 11, 2006
Last modified: November 11, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.