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Protein

Glutamine synthetase

Gene

YPA_3517

Organism
Yersinia pestis bv. Antiqua (strain Antiqua)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. glutamine biosynthetic process Source: InterPro
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciYPES360102:GHZU-3592-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetaseUniRule annotation (EC:6.3.1.2UniRule annotation)
Gene namesi
Ordered Locus Names:YPA_3517Imported
OrganismiYersinia pestis bv. Antiqua (strain Antiqua)Imported
Taxonomic identifieri360102 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeYersinia
ProteomesiUP000001971: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.UniRule annotation

Protein-protein interaction databases

STRINGi360102.YPA_3517.

Structurei

3D structure databases

ProteinModelPortaliQ1C243.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
KOiK01915.
OMAiKVLNQVG.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1C243-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAEHVLTML NEHEVKFVDL RFTDTKGKEQ HITIPAHQVN ADFFEEGKMF
60 70 80 90 100
DGSSIGGWKG INESDMVLMP DASTAVMDPF FADSTLIIRC DILEPGTMQG
110 120 130 140 150
YDRDPRSISK RAEDFLKSSG IADTVLFGPE PEFFLFDDIR FGSSINGSHV
160 170 180 190 200
SIDDVEGAWN SSTKYEGGNK GHRPAVKGGY FPVPPVDSAQ DLRSAMCLTM
210 220 230 240 250
EEMGLVVEAH HHEVATAGQN EVATRFNTMT KKADEIQIYK YVVHNVAHAF
260 270 280 290 300
GKTATFMPKP MFGDNGSGMH CHMSLSKNGN NLFAGDKYGG LSEIALFYIG
310 320 330 340 350
GIIKHAKAIN ALANPTTNSY KRLVPGYEAP VMLAYSARNR SASIRIPVVA
360 370 380 390 400
SPKARRIEAR FPDPAANPYL CFAALLMAGL DGIINKIHPG DAMDKNLYDL
410 420 430 440 450
PPEEEAEIPK VAGSLDEAMA ALNEDREFLT RGGVFTDDAI DAYIELRREE
460
MDRVRMTPHP VEFELYYSV
Length:469
Mass (Da):51,735
Last modified:July 11, 2006 - v1
Checksum:i0AE847A5BFD2488C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG15479.1.
RefSeqiYP_653424.1. NC_008150.1.

Genome annotation databases

EnsemblBacteriaiABG15479; ABG15479; YPA_3517.
GeneIDi4119605.
KEGGiypa:YPA_3517.
PATRICi18586951. VBIYerPes1796_4265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000308 Genomic DNA. Translation: ABG15479.1.
RefSeqiYP_653424.1. NC_008150.1.

3D structure databases

ProteinModelPortaliQ1C243.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360102.YPA_3517.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG15479; ABG15479; YPA_3517.
GeneIDi4119605.
KEGGiypa:YPA_3517.
PATRICi18586951. VBIYerPes1796_4265.

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000005157.
KOiK01915.
OMAiKVLNQVG.
OrthoDBiEOG6B360N.

Enzyme and pathway databases

BioCyciYPES360102:GHZU-3592-MONOMER.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Yersinia pestis strains Antiqua and Nepal516: evidence of gene reduction in an emerging pathogen."
    Chain P.S.G., Hu P., Malfatti S.A., Radnedge L., Larimer F., Vergez L.M., Worsham P., Chu M.C., Andersen G.L.
    J. Bacteriol. 188:4453-4463(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AntiquaImported.

Entry informationi

Entry nameiQ1C243_YERPA
AccessioniPrimary (citable) accession number: Q1C243
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: January 7, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.