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Q1BZG6 (MRAY_BURCA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase

EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:Bcen_0074
OrganismBurkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]
Taxonomic identifier331271 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length389 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP-Rule MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 389389Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP-Rule MF_00038
PRO_1000002944

Regions

Transmembrane25 – 4521Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane135 – 15521Helical; Potential
Transmembrane190 – 21021Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane258 – 27821Helical; Potential
Transmembrane286 – 30621Helical; Potential
Transmembrane311 – 33121Helical; Potential
Transmembrane366 – 38621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q1BZG6 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 4717CF0183877833

FASTA38942,808
        10         20         30         40         50         60 
MLLALAQWLQ GDASFLRLFT YLTFRAVMAT ITALGIGLVC GPWVIRKLTQ MKVGQAVRKD 

        70         80         90        100        110        120 
GPQTHLVKSG TPTMGGVLIL IGIAVATLLW GDLTNRFIWI VMLVTFGFGV IGWVDDYRKV 

       130        140        150        160        170        180 
VHKDPRGMSS REKYFWQSVI GLFAAVYLAF SVSEANNVRV FDLFMAWVRS GLSMGLPARA 

       190        200        210        220        230        240 
DLMLPFLKSI SYPLGVWGFI VLTYFVIVGA SNAVNLTDGL DGLVIMPVVL VGASLGVFAY 

       250        260        270        280        290        300 
VMGSAVYSKY LLFPHIPGAG ELLIFCSAMG GAGLAFLWYN THPAQVFMGD VGALALGGAL 

       310        320        330        340        350        360 
GTVAVIVRQE IVLFIMGGIF VAETLSVMLQ VSWFKYTKKR YGEGRRLLKM APLHHHFELS 

       370        380 
GWKETQVVVR FWIITLMLCL FGLTTLKLR 

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AU 1054.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000378 Genomic DNA. Translation: ABF74989.1.
RefSeqYP_619962.1. NC_008060.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING331271.Bcen_0074.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF74989; ABF74989; Bcen_0074.
GeneID4091835.
KEGGbcn:Bcen_0074.
PATRIC19043574. VBIBurCen11237_0072.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHOG000275122.
KOK01000.
OMAQIHYVSG.
OrthoDBEOG69GZPZ.

Enzyme and pathway databases

BioCycBCEN331271:GHKX-78-MONOMER.
UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00038. MraY.
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. PTHR22926. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. mraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_BURCA
AccessionPrimary (citable) accession number: Q1BZG6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways