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Q1BZG6

- MRAY_BURCA

UniProt

Q1BZG6 - MRAY_BURCA

Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

    Catalytic activityi

    UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: UniProtKB-HAMAP
    2. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    4. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBCEN331271:GHKX-78-MONOMER.
    UniPathwayiUPA00219.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
    Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
    Gene namesi
    Name:mraYUniRule annotation
    Ordered Locus Names:Bcen_0074
    OrganismiBurkholderia cenocepacia (strain AU 1054)
    Taxonomic identifieri331271 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002400: Chromosome 1

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 389389Phospho-N-acetylmuramoyl-pentapeptide-transferasePRO_1000002944Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331271.Bcen_0074.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalUniRule annotationAdd
    BLAST
    Transmembranei73 – 9321HelicalUniRule annotationAdd
    BLAST
    Transmembranei97 – 11721HelicalUniRule annotationAdd
    BLAST
    Transmembranei135 – 15521HelicalUniRule annotationAdd
    BLAST
    Transmembranei190 – 21021HelicalUniRule annotationAdd
    BLAST
    Transmembranei222 – 24221HelicalUniRule annotationAdd
    BLAST
    Transmembranei258 – 27821HelicalUniRule annotationAdd
    BLAST
    Transmembranei286 – 30621HelicalUniRule annotationAdd
    BLAST
    Transmembranei311 – 33121HelicalUniRule annotationAdd
    BLAST
    Transmembranei366 – 38621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0472.
    HOGENOMiHOG000275122.
    KOiK01000.
    OMAiQIHYVSG.
    OrthoDBiEOG69GZPZ.

    Family and domain databases

    HAMAPiMF_00038. MraY.
    InterProiIPR000715. Glycosyl_transferase_4.
    IPR003524. PNAcMuramoyl-5peptid_Trfase.
    IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
    [Graphical view]
    PANTHERiPTHR22926. PTHR22926. 1 hit.
    PfamiPF00953. Glycos_transf_4. 1 hit.
    PF10555. MraY_sig1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00445. mraY. 1 hit.
    PROSITEiPS01347. MRAY_1. 1 hit.
    PS01348. MRAY_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1BZG6-1 [UniParc]FASTAAdd to Basket

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    MLLALAQWLQ GDASFLRLFT YLTFRAVMAT ITALGIGLVC GPWVIRKLTQ    50
    MKVGQAVRKD GPQTHLVKSG TPTMGGVLIL IGIAVATLLW GDLTNRFIWI 100
    VMLVTFGFGV IGWVDDYRKV VHKDPRGMSS REKYFWQSVI GLFAAVYLAF 150
    SVSEANNVRV FDLFMAWVRS GLSMGLPARA DLMLPFLKSI SYPLGVWGFI 200
    VLTYFVIVGA SNAVNLTDGL DGLVIMPVVL VGASLGVFAY VMGSAVYSKY 250
    LLFPHIPGAG ELLIFCSAMG GAGLAFLWYN THPAQVFMGD VGALALGGAL 300
    GTVAVIVRQE IVLFIMGGIF VAETLSVMLQ VSWFKYTKKR YGEGRRLLKM 350
    APLHHHFELS GWKETQVVVR FWIITLMLCL FGLTTLKLR 389
    Length:389
    Mass (Da):42,808
    Last modified:July 11, 2006 - v1
    Checksum:i4717CF0183877833
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000378 Genomic DNA. Translation: ABF74989.1.
    RefSeqiYP_619962.1. NC_008060.1.

    Genome annotation databases

    EnsemblBacteriaiABF74989; ABF74989; Bcen_0074.
    GeneIDi4091835.
    KEGGibcn:Bcen_0074.
    PATRICi19043574. VBIBurCen11237_0072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000378 Genomic DNA. Translation: ABF74989.1 .
    RefSeqi YP_619962.1. NC_008060.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331271.Bcen_0074.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF74989 ; ABF74989 ; Bcen_0074 .
    GeneIDi 4091835.
    KEGGi bcn:Bcen_0074.
    PATRICi 19043574. VBIBurCen11237_0072.

    Phylogenomic databases

    eggNOGi COG0472.
    HOGENOMi HOG000275122.
    KOi K01000.
    OMAi QIHYVSG.
    OrthoDBi EOG69GZPZ.

    Enzyme and pathway databases

    UniPathwayi UPA00219 .
    BioCyci BCEN331271:GHKX-78-MONOMER.

    Family and domain databases

    HAMAPi MF_00038. MraY.
    InterProi IPR000715. Glycosyl_transferase_4.
    IPR003524. PNAcMuramoyl-5peptid_Trfase.
    IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
    [Graphical view ]
    PANTHERi PTHR22926. PTHR22926. 1 hit.
    Pfami PF00953. Glycos_transf_4. 1 hit.
    PF10555. MraY_sig1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00445. mraY. 1 hit.
    PROSITEi PS01347. MRAY_1. 1 hit.
    PS01348. MRAY_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AU 1054.

    Entry informationi

    Entry nameiMRAY_BURCA
    AccessioniPrimary (citable) accession number: Q1BZG6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3