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Q1BZG6

- MRAY_BURCA

UniProt

Q1BZG6 - MRAY_BURCA

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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene
mraY, Bcen_0074
Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phospho-N-acetylmuramoyl-pentapeptide-transferase activity Source: UniProtKB-HAMAP
  2. UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  4. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBCEN331271:GHKX-78-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC:2.7.8.13)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene namesi
Name:mraY
Ordered Locus Names:Bcen_0074
OrganismiBurkholderia cenocepacia (strain AU 1054)
Taxonomic identifieri331271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002400: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei25 – 4521Helical; Reviewed predictionAdd
BLAST
Transmembranei73 – 9321Helical; Reviewed predictionAdd
BLAST
Transmembranei97 – 11721Helical; Reviewed predictionAdd
BLAST
Transmembranei135 – 15521Helical; Reviewed predictionAdd
BLAST
Transmembranei190 – 21021Helical; Reviewed predictionAdd
BLAST
Transmembranei222 – 24221Helical; Reviewed predictionAdd
BLAST
Transmembranei258 – 27821Helical; Reviewed predictionAdd
BLAST
Transmembranei286 – 30621Helical; Reviewed predictionAdd
BLAST
Transmembranei311 – 33121Helical; Reviewed predictionAdd
BLAST
Transmembranei366 – 38621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotationPRO_1000002944Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331271.Bcen_0074.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0472.
HOGENOMiHOG000275122.
KOiK01000.
OMAiQIHYVSG.
OrthoDBiEOG69GZPZ.

Family and domain databases

HAMAPiMF_00038. MraY.
InterProiIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1BZG6-1 [UniParc]FASTAAdd to Basket

« Hide

MLLALAQWLQ GDASFLRLFT YLTFRAVMAT ITALGIGLVC GPWVIRKLTQ    50
MKVGQAVRKD GPQTHLVKSG TPTMGGVLIL IGIAVATLLW GDLTNRFIWI 100
VMLVTFGFGV IGWVDDYRKV VHKDPRGMSS REKYFWQSVI GLFAAVYLAF 150
SVSEANNVRV FDLFMAWVRS GLSMGLPARA DLMLPFLKSI SYPLGVWGFI 200
VLTYFVIVGA SNAVNLTDGL DGLVIMPVVL VGASLGVFAY VMGSAVYSKY 250
LLFPHIPGAG ELLIFCSAMG GAGLAFLWYN THPAQVFMGD VGALALGGAL 300
GTVAVIVRQE IVLFIMGGIF VAETLSVMLQ VSWFKYTKKR YGEGRRLLKM 350
APLHHHFELS GWKETQVVVR FWIITLMLCL FGLTTLKLR 389
Length:389
Mass (Da):42,808
Last modified:July 11, 2006 - v1
Checksum:i4717CF0183877833
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000378 Genomic DNA. Translation: ABF74989.1.
RefSeqiYP_619962.1. NC_008060.1.

Genome annotation databases

EnsemblBacteriaiABF74989; ABF74989; Bcen_0074.
GeneIDi4091835.
KEGGibcn:Bcen_0074.
PATRICi19043574. VBIBurCen11237_0072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000378 Genomic DNA. Translation: ABF74989.1 .
RefSeqi YP_619962.1. NC_008060.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331271.Bcen_0074.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF74989 ; ABF74989 ; Bcen_0074 .
GeneIDi 4091835.
KEGGi bcn:Bcen_0074.
PATRICi 19043574. VBIBurCen11237_0072.

Phylogenomic databases

eggNOGi COG0472.
HOGENOMi HOG000275122.
KOi K01000.
OMAi QIHYVSG.
OrthoDBi EOG69GZPZ.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci BCEN331271:GHKX-78-MONOMER.

Family and domain databases

HAMAPi MF_00038. MraY.
InterProi IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view ]
PANTHERi PTHR22926. PTHR22926. 1 hit.
Pfami PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00445. mraY. 1 hit.
PROSITEi PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AU 1054.

Entry informationi

Entry nameiMRAY_BURCA
AccessioniPrimary (citable) accession number: Q1BZG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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