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Protein

NAD kinase

Gene

nadK

Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75Proton acceptorUniRule annotation1
Binding sitei177NADUniRule annotation1
Binding sitei179NADUniRule annotation1
Binding sitei214NAD; via carbonyl oxygenUniRule annotation1
Binding sitei248NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 76NADUniRule annotation2
Nucleotide bindingi149 – 150NADUniRule annotation2
Nucleotide bindingi190 – 195NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Bcen_0260
OrganismiBurkholderia cenocepacia (strain AU 1054)
Taxonomic identifieri331271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002400 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000053911 – 300NAD kinaseAdd BLAST300

Proteomic databases

PRIDEiQ1BYY1

Structurei

3D structure databases

ProteinModelPortaliQ1BYY1
SMRiQ1BYY1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227221
KOiK00858
OMAiVNLGHVG

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q1BYY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTGNQFKTV ALVGRSNTPG IAEPLATLAD SIATLGFEVV FEGDTAREIG
60 70 80 90 100
IAGYPALTPA EIGARADVAI VLGGDGTMLG IGRQLAPYRT PLIGINHGRL
110 120 130 140 150
GFITDIAASD MQALVPVMLA GKFEREERSL LEARIVRDGE PIYHALAFND
160 170 180 190 200
VVVNRSGFSG MVELRASVDG RYMYNQRSDG LIVATPTGST AYALSSAGPI
210 220 230 240 250
LHPQLAGVVL VPIAPHALSN RPIVLPDDSK IAIQIVGGRD VNVNFDMQSF
260 270 280 290 300
TSLELNDTIE VRRSKHTVPF LHPIGYSYYT TLRKKLHWNE HASNEDDKAS
Length:300
Mass (Da):32,276
Last modified:July 11, 2006 - v1
Checksum:i3FE33D74AE3C646A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000378 Genomic DNA Translation: ABF75174.1
RefSeqiWP_011544636.1, NC_008060.1

Genome annotation databases

EnsemblBacteriaiABF75174; ABF75174; Bcen_0260
KEGGibcn:Bcen_0260

Similar proteinsi

Entry informationi

Entry nameiNADK_BURCA
AccessioniPrimary (citable) accession number: Q1BYY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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