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Q1BYW4

- PUR5_BURCA

UniProt

Q1BYW4 - PUR5_BURCA

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCEN331271:GHKX-283-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:Bcen_0277
OrganismiBurkholderia cenocepacia (strain AU 1054)
Taxonomic identifieri331271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002400: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Phosphoribosylformylglycinamidine cyclo-ligasePRO_0000258338Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331271.Bcen_0277.

Structurei

3D structure databases

ProteinModelPortaliQ1BYW4.
SMRiQ1BYW4. Positions 13-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1BYW4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPPKSAPDA QGLSYRDAGV DIDAGDALID KIKPFAKKTL RDGVLGGIGG
60 70 80 90 100
FGALFEVPKK YKEPVLVSGT DGVGTKLKLA FHLNKHDTVG QDLVAMSVND
110 120 130 140 150
ILVQGAEPLF FLDYFACGKL DVDTAATVVK GIAQGCELSG CALIGGETAE
160 170 180 190 200
MPGMYPDGEY DLAGFAVGAV EKSKIIDGST IAEGDVVLGL ASSGIHSNGF
210 220 230 240 250
SLVRKIIERA NPDLSADFHG RSLADALMAP TRIYVKPLLA LMQKLSVKGM
260 270 280 290 300
AHITGGGLVE NIPRVLRDGL TAELDQNAWP LPPLFKWLQE HGGVADAEMH
310 320 330 340 350
RVFNCGIGMA VIVSAADADA AIADLTAAGE QVWKIGTVRA TREGEAQTVV

V
Length:351
Mass (Da):36,779
Last modified:July 11, 2006 - v1
Checksum:i946F04B5951BDB5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000378 Genomic DNA. Translation: ABF75191.1.
RefSeqiYP_620164.1. NC_008060.1.

Genome annotation databases

EnsemblBacteriaiABF75191; ABF75191; Bcen_0277.
GeneIDi4092225.
KEGGibcn:Bcen_0277.
PATRICi19044009. VBIBurCen11237_0288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000378 Genomic DNA. Translation: ABF75191.1 .
RefSeqi YP_620164.1. NC_008060.1.

3D structure databases

ProteinModelPortali Q1BYW4.
SMRi Q1BYW4. Positions 13-350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331271.Bcen_0277.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF75191 ; ABF75191 ; Bcen_0277 .
GeneIDi 4092225.
KEGGi bcn:Bcen_0277.
PATRICi 19044009. VBIBurCen11237_0288.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci BCEN331271:GHKX-283-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741. AIRS.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AU 1054.

Entry informationi

Entry nameiPUR5_BURCA
AccessioniPrimary (citable) accession number: Q1BYW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3