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Q1BYS0 (Q1BYS0_BURCA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine hydroxymethyltransferase 1 HAMAP MF_00051
Short name=SHMT 1 HAMAP MF_00051
Short name=Serine methylase 1 HAMAP MF_00051
EC=2.1.2.1 HAMAP MF_00051
Gene names
Name:glyA1 HAMAP MF_00051
Ordered Locus Names:Bcen_0323
OrganismBurkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]
Taxonomic identifier331271 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interconversion of serine and glycine By similarity. RuleBase RU000585 HAMAP MF_00051

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. RuleBase RU000585 HAMAP MF_00051

Cofactor

Pyridoxal phosphate By similarity. RuleBase RU000585 HAMAP MF_00051

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051

One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU000585

Subunit structure

Homotetramer By similarity. HAMAP MF_00051

Subcellular location

Cytoplasm By similarity HAMAP MF_00051.

Sequence similarities

Belongs to the SHMT family. RuleBase RU004104 HAMAP MF_00051

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Amino acid modifications

Modified residue3061N6-(pyridoxal phosphate)lysine By similarity HAMAP MF_00051

Sequences

Sequence LengthMass (Da)Tools
Q1BYS0 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: F61DAC9C47069850

FASTA49152,909
        10         20         30         40         50         60 
MTGDRTLRVQ GGASHREARG AVFAVRLGSR CAPSRASPVA VLPRVIRILP PRRAGLASSA 

        70         80         90        100        110        120 
PYSATPVNLY TLNGNRMFDR AQSTIANVDP EIFAAIEQEN RRQEDHIELI ASENYTSPAV 

       130        140        150        160        170        180 
MAAQGSQLTN KYAEGYPGKR YYGGCEYVDV VEQLAIDRVK QLFGAEAANV QPNSGSQANQ 

       190        200        210        220        230        240 
GVFFAMLKPG DTIMGMSLAH GGHLTHGSPV NMSGKWFNVV SYGLNENEDI DYEAAEKLAQ 

       250        260        270        280        290        300 
EHKPKLIVAG ASAFALKIDF ERLAKIAKSV GAYLMVDMAH YAGLIAAGVY PNPVPHADFV 

       310        320        330        340        350        360 
TTTTHKSLRG PRGGVILMKA EYEKPINSAI FPGIQGGPLM HVIAAKAVAF KEALSPEFKE 

       370        380        390        400        410        420 
YQQKVVENAR VLAETLVKRG LRIVSGRTES HVMLVDLRAK NITGKAAEAA LGAAHITVNK 

       430        440        450        460        470        480 
NAIPNDPEKP FVTSGVRLGS PAMTTRGFGP AEAEQVGNLI ADVLENPEDA ATIERVRAQV 

       490 
AELTKRFPVY R

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References

[1]"Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AU 1054.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000378 Genomic DNA. Translation: ABF75235.1.
RefSeqYP_620208.2. NC_008060.1.

3D structure databases

ProteinModelPortalQ1BYS0.
SMRQ1BYS0. Positions 80-490.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1BYS0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4090796.
GenomeReviewsGene locus Bcen_0323 in contig CP000378_GR.
KEGGbcn:Bcen_0323.
PATRIC19044103. VBIBurCen11237_0334.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0112.
HOGENOMHBG301263.
OMAAHMTINK.
PhylomeDBQ1BYS0.
ProtClustDBPRK00011.

Family and domain databases

HAMAPMF_00051. SHMT.
[Tree]
InterProIPR015424. PyrdxlP-dep_Trfase_major_dom.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
Gene3DG3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KOK00600.
PANTHERPTHR11680. Gly_HO-Metrfase. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1BYS0_BURCA
AccessionPrimary (citable) accession number: Q1BYS0
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: December 14, 2011
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info