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Q1BYA7

- GLK_BURCA

UniProt

Q1BYA7 - GLK_BURCA

Protein

Bifunctional protein glk

Gene

glk

Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + D-glucose = ADP + D-glucose 6-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi23 – 286ATPSequence Analysis
    DNA bindingi377 – 39620H-T-H motifBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. carbohydrate binding Source: InterPro
    3. DNA binding Source: UniProtKB-KW
    4. glucokinase activity Source: UniProtKB-EC
    5. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis, Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCEN331271:GHKX-494-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein glk
    Including the following 2 domains:
    Glucokinase (EC:2.7.1.2)
    Alternative name(s):
    Glucose kinase
    Putative HTH-type transcriptional regulator
    Gene namesi
    Name:glk
    Ordered Locus Names:Bcen_0486
    OrganismiBurkholderia cenocepacia (strain AU 1054)
    Taxonomic identifieri331271 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002400: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 642642Bifunctional protein glkPRO_0000268796Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331271.Bcen_0486.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1BYA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei576 – 59621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini341 – 41777HTH rpiR-typeAdd
    BLAST
    Domaini461 – 600140SISAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 340340GlucokinaseAdd
    BLAST
    Regioni341 – 642302Putative HTH-type transcriptional regulatorAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the bacterial glucokinase family.Curated
    Contains 1 SIS domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1737.
    HOGENOMiHOG000257466.
    KOiK00845.
    OMAiQYARKKW.
    OrthoDBiEOG64BQ47.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    HAMAPiMF_00524. Glucokinase.
    InterProiIPR003836. Glucokinase.
    IPR009057. Homeodomain-like.
    IPR000281. HTH_RpiR.
    IPR001347. SIS.
    IPR000843. Tscrpt_reg_HTH_LacI.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF02685. Glucokinase. 1 hit.
    PF01418. HTH_6. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    TIGRFAMsiTIGR00749. glk. 1 hit.
    PROSITEiPS00356. HTH_LACI_1. 1 hit.
    PS51071. HTH_RPIR. 1 hit.
    PS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1BYA7-1 [UniParc]FASTAAdd to Basket

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    MSTGAQSKAV VAGQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA    50
    DYPTITDAIR KYLKDVKISR VNHAAIAIAN PVDGDQVTMT NHDWSFSIEA 100
    TRRALGFDTL LVVNDFTALA MALPGLTDAQ RVQVGGGARR QNSVIGLLGP 150
    GTGLGVSGLI PADDRWIALG SEGGHASFAP QDEREDLVLQ YARKKFPHVS 200
    FERVCAGPGM EIIYRALAAR DKKRVAATVD TVEIVERAHA GDALALETVE 250
    CFCGILGAFA GSVALTLGAL GGVYIGGGVA LKLGELFTRS SFRARFEAKG 300
    RFTHYLENIP TYLITAEYPA FLGVSAILAE QLSNRSGGAS SAVFERIRQM 350
    RDALTPAERR VADLALNHPR SIINDPIVDI ARKADVSQPT VIRFCRSLGC 400
    QGLSDFKLKL ATGLTGTIPM SHSQVHLGDT ATDFGAKVLD NTVSAILQLR 450
    EHLNFEHVEN AIEILNGARR IEFYGLGNSN IVAQDAHYKF FRFGIPTIAY 500
    GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ AGAKVIAITS 550
    SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLLMIDIL AVGVAIRRAS 600
    TNGELPEAVA QAKARASDDE TADVLDWLSH GASPAAKDVA RD 642
    Length:642
    Mass (Da):68,521
    Last modified:July 11, 2006 - v1
    Checksum:i3748356F462BC6B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000378 Genomic DNA. Translation: ABF75398.1.
    RefSeqiYP_620371.1. NC_008060.1.

    Genome annotation databases

    EnsemblBacteriaiABF75398; ABF75398; Bcen_0486.
    GeneIDi4092635.
    KEGGibcn:Bcen_0486.
    PATRICi19044429. VBIBurCen11237_0495.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000378 Genomic DNA. Translation: ABF75398.1 .
    RefSeqi YP_620371.1. NC_008060.1.

    3D structure databases

    ProteinModelPortali Q1BYA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331271.Bcen_0486.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF75398 ; ABF75398 ; Bcen_0486 .
    GeneIDi 4092635.
    KEGGi bcn:Bcen_0486.
    PATRICi 19044429. VBIBurCen11237_0495.

    Phylogenomic databases

    eggNOGi COG1737.
    HOGENOMi HOG000257466.
    KOi K00845.
    OMAi QYARKKW.
    OrthoDBi EOG64BQ47.

    Enzyme and pathway databases

    BioCyci BCEN331271:GHKX-494-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    HAMAPi MF_00524. Glucokinase.
    InterProi IPR003836. Glucokinase.
    IPR009057. Homeodomain-like.
    IPR000281. HTH_RpiR.
    IPR001347. SIS.
    IPR000843. Tscrpt_reg_HTH_LacI.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02685. Glucokinase. 1 hit.
    PF01418. HTH_6. 1 hit.
    PF01380. SIS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    TIGRFAMsi TIGR00749. glk. 1 hit.
    PROSITEi PS00356. HTH_LACI_1. 1 hit.
    PS51071. HTH_RPIR. 1 hit.
    PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AU 1054.

    Entry informationi

    Entry nameiGLK_BURCA
    AccessioniPrimary (citable) accession number: Q1BYA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3