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Q1BYA7

- GLK_BURCA

UniProt

Q1BYA7 - GLK_BURCA

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Protein
Bifunctional protein glk
Gene
glk, Bcen_0486
Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 286ATP Reviewed prediction
DNA bindingi377 – 39620H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. carbohydrate binding Source: InterPro
  4. glucokinase activity Source: UniProtKB-EC
  5. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCEN331271:GHKX-494-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein glk
Including the following 2 domains:
Glucokinase (EC:2.7.1.2)
Alternative name(s):
Glucose kinase
Putative HTH-type transcriptional regulator
Gene namesi
Name:glk
Ordered Locus Names:Bcen_0486
OrganismiBurkholderia cenocepacia (strain AU 1054)
Taxonomic identifieri331271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002400: Chromosome 1

Subcellular locationi

Membrane; Single-pass membrane protein Reviewed prediction UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei576 – 59621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 642642Bifunctional protein glkUniRule annotation
PRO_0000268796Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331271.Bcen_0486.

Structurei

3D structure databases

ProteinModelPortaliQ1BYA7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini341 – 41777HTH rpiR-type
Add
BLAST
Domaini461 – 600140SIS
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 340340GlucokinaseUniRule annotation
Add
BLAST
Regioni341 – 642302Putative HTH-type transcriptional regulatorUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the bacterial glucokinase family.
Contains 1 SIS domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1737.
HOGENOMiHOG000257466.
KOiK00845.
OMAiQYARKKW.
OrthoDBiEOG64BQ47.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_00524. Glucokinase.
InterProiIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.
PROSITEiPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1BYA7-1 [UniParc]FASTAAdd to Basket

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MSTGAQSKAV VAGQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA    50
DYPTITDAIR KYLKDVKISR VNHAAIAIAN PVDGDQVTMT NHDWSFSIEA 100
TRRALGFDTL LVVNDFTALA MALPGLTDAQ RVQVGGGARR QNSVIGLLGP 150
GTGLGVSGLI PADDRWIALG SEGGHASFAP QDEREDLVLQ YARKKFPHVS 200
FERVCAGPGM EIIYRALAAR DKKRVAATVD TVEIVERAHA GDALALETVE 250
CFCGILGAFA GSVALTLGAL GGVYIGGGVA LKLGELFTRS SFRARFEAKG 300
RFTHYLENIP TYLITAEYPA FLGVSAILAE QLSNRSGGAS SAVFERIRQM 350
RDALTPAERR VADLALNHPR SIINDPIVDI ARKADVSQPT VIRFCRSLGC 400
QGLSDFKLKL ATGLTGTIPM SHSQVHLGDT ATDFGAKVLD NTVSAILQLR 450
EHLNFEHVEN AIEILNGARR IEFYGLGNSN IVAQDAHYKF FRFGIPTIAY 500
GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ AGAKVIAITS 550
SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLLMIDIL AVGVAIRRAS 600
TNGELPEAVA QAKARASDDE TADVLDWLSH GASPAAKDVA RD 642
Length:642
Mass (Da):68,521
Last modified:July 11, 2006 - v1
Checksum:i3748356F462BC6B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000378 Genomic DNA. Translation: ABF75398.1.
RefSeqiYP_620371.1. NC_008060.1.

Genome annotation databases

EnsemblBacteriaiABF75398; ABF75398; Bcen_0486.
GeneIDi4092635.
KEGGibcn:Bcen_0486.
PATRICi19044429. VBIBurCen11237_0495.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000378 Genomic DNA. Translation: ABF75398.1 .
RefSeqi YP_620371.1. NC_008060.1.

3D structure databases

ProteinModelPortali Q1BYA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331271.Bcen_0486.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF75398 ; ABF75398 ; Bcen_0486 .
GeneIDi 4092635.
KEGGi bcn:Bcen_0486.
PATRICi 19044429. VBIBurCen11237_0495.

Phylogenomic databases

eggNOGi COG1737.
HOGENOMi HOG000257466.
KOi K00845.
OMAi QYARKKW.
OrthoDBi EOG64BQ47.

Enzyme and pathway databases

BioCyci BCEN331271:GHKX-494-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
HAMAPi MF_00524. Glucokinase.
InterProi IPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
TIGRFAMsi TIGR00749. glk. 1 hit.
PROSITEi PS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AU 1054.

Entry informationi

Entry nameiGLK_BURCA
AccessioniPrimary (citable) accession number: Q1BYA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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