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Q1BYA7 (GLK_BURCA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein glk

Including the following 2 domains:

  1. Glucokinase
    EC=2.7.1.2
    Alternative name(s):
    Glucose kinase
  2. Putative HTH-type transcriptional regulator
Gene names
Name:glk
Ordered Locus Names:Bcen_0486
OrganismBurkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]
Taxonomic identifier331271 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length642 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-glucose = ADP + D-glucose 6-phosphate. HAMAP-Rule MF_00524

Subcellular location

Membrane; Single-pass membrane protein Potential HAMAP-Rule MF_00524.

Sequence similarities

In the N-terminal section; belongs to the bacterial glucokinase family.

Contains 1 HTH rpiR-type DNA-binding domain.

Contains 1 SIS domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 642642Bifunctional protein glk HAMAP-Rule MF_00524
PRO_0000268796

Regions

Transmembrane576 – 59621Helical; Potential
Domain341 – 41777HTH rpiR-type
Domain461 – 600140SIS
Nucleotide binding23 – 286ATP Potential
DNA binding377 – 39620H-T-H motif By similarity
Region1 – 340340Glucokinase HAMAP-Rule MF_00524
Region341 – 642302Putative HTH-type transcriptional regulator HAMAP-Rule MF_00524

Sequences

Sequence LengthMass (Da)Tools
Q1BYA7 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 3748356F462BC6B6

FASTA64268,521
        10         20         30         40         50         60 
MSTGAQSKAV VAGQHADGPR LLADVGGTNA RFALETGPGE ITQIRVYPGA DYPTITDAIR 

        70         80         90        100        110        120 
KYLKDVKISR VNHAAIAIAN PVDGDQVTMT NHDWSFSIEA TRRALGFDTL LVVNDFTALA 

       130        140        150        160        170        180 
MALPGLTDAQ RVQVGGGARR QNSVIGLLGP GTGLGVSGLI PADDRWIALG SEGGHASFAP 

       190        200        210        220        230        240 
QDEREDLVLQ YARKKFPHVS FERVCAGPGM EIIYRALAAR DKKRVAATVD TVEIVERAHA 

       250        260        270        280        290        300 
GDALALETVE CFCGILGAFA GSVALTLGAL GGVYIGGGVA LKLGELFTRS SFRARFEAKG 

       310        320        330        340        350        360 
RFTHYLENIP TYLITAEYPA FLGVSAILAE QLSNRSGGAS SAVFERIRQM RDALTPAERR 

       370        380        390        400        410        420 
VADLALNHPR SIINDPIVDI ARKADVSQPT VIRFCRSLGC QGLSDFKLKL ATGLTGTIPM 

       430        440        450        460        470        480 
SHSQVHLGDT ATDFGAKVLD NTVSAILQLR EHLNFEHVEN AIEILNGARR IEFYGLGNSN 

       490        500        510        520        530        540 
IVAQDAHYKF FRFGIPTIAY GDLYMQAASA ALLGKGDVIV AVSKSGRAPE LLRVLDVAMQ 

       550        560        570        580        590        600 
AGAKVIAITS SNTPLAKRAT VALETDHIEM RESQLSMISR ILHLLMIDIL AVGVAIRRAS 

       610        620        630        640 
TNGELPEAVA QAKARASDDE TADVLDWLSH GASPAAKDVA RD 

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AU 1054.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000378 Genomic DNA. Translation: ABF75398.1.
RefSeqYP_620371.1. NC_008060.1.

3D structure databases

ProteinModelPortalQ1BYA7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING331271.Bcen_0486.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF75398; ABF75398; Bcen_0486.
GeneID4092635.
KEGGbcn:Bcen_0486.
PATRIC19044429. VBIBurCen11237_0495.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1737.
HOGENOMHOG000257466.
KOK00845.
OMAQYARKKW.
OrthoDBEOG64BQ47.
ProtClustDBPRK14101.

Enzyme and pathway databases

BioCycBCEN331271:GHKX-494-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
HAMAPMF_00524. Glucokinase.
InterProIPR003836. Glucokinase.
IPR009057. Homeodomain-like.
IPR000281. HTH_RpiR.
IPR001347. SIS.
IPR000843. Tscrpt_reg_HTH_LacI.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF02685. Glucokinase. 1 hit.
PF01418. HTH_6. 1 hit.
PF01380. SIS. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
TIGRFAMsTIGR00749. glk. 1 hit.
PROSITEPS00356. HTH_LACI_1. 1 hit.
PS51071. HTH_RPIR. 1 hit.
PS51464. SIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLK_BURCA
AccessionPrimary (citable) accession number: Q1BYA7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 11, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families