Q1BY59 (F16PA_BURCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-1,6-bisphosphatase class 1
Short name=FBPase class 1
EC=3.1.3.11

Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Gene names

Name:	fbp
Ordered Locus Names:	Bcen_0535

Organism

Burkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]

Taxonomic identifier

331271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity. HAMAP MF_01855
Subcellular location	Cytoplasm Potential HAMAP MF_01855.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855		PRO_0000364486
Regions
	Region	119 – 122	4	Substrate binding By similarity
Sites
	Metal binding	94	1	Magnesium 1 By similarity
	Metal binding	116	1	Magnesium 1 By similarity
	Metal binding	116	1	Magnesium 2 By similarity
	Metal binding	118	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	119	1	Magnesium 2 By similarity
	Metal binding	282	1	Magnesium 2 By similarity
	Binding site	210	1	Substrate By similarity
	Binding site	276	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1BY59 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: DF61320E69D931F7	FASTA	337	37,126
	10 20 30 40 50 60 MSIARRTTLS KFLIEQQRET NNLPADLRLL IEVVARACKA ISYNVSKGAL GDALGTAGSE 70 80 90 100 110 120 NVQGEVQKKL DILSNEILLD ANEWGGNLAA MASEEMETFF PIPANYPRGE YLLVFDPLDG 130 140 150 160 170 180 SSNIDVNVSI GTIFSVLRCP DGKQATEESF LQPGTEQVAA GYAVYGPQTV FVLTTGNGVN 190 200 210 220 230 240 CFTLDREVGS WVLTQSNMQI PADTREYAIN ASNARHWYDP VKRYVDELNA GKDGPRGDNF 250 260 270 280 290 300 NMRWIASMVA DVHRILNRGG IFMYPADKRT PDRPGKLRLM YEANPMSFIV EQAGGAATTG 310 320 330 TQRIMEVQPT GLHQRVPVFL GSKNEVKRVT GYHDEAK

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AU 1054.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000378 Genomic DNA. Translation: ABF75446.1.
RefSeq	YP_620419.1. NC_008060.1.
3D structure databases
ProteinModelPortal	Q1BY59.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1BY59.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4093159.
GenomeReviews	Gene locus Bcen_0535 in contig CP000378_GR.
KEGG	bcn:Bcen_0535.
PATRIC	19044540. VBIBurCen11237_0544.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0158.
HOGENOM	HBG731261.
OMA	HWEAPVQ.
PhylomeDB	Q1BY59.
ProtClustDB	PRK09293.
Enzyme and pathway databases
BioCyc	BCEN331271:BCEN_0535-MONOMER.
Family and domain databases
HAMAP	MF_01855. FBPase_class1. [Tree]
InterPro	IPR000146. FBPase_class-1/SBPase. [Graphical view]
KO	K03841.
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PIRSF	PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTS	PR00115. F16BPHPHTASE.
PROSITE	PS00124. FBPASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16PA_BURCA

Accession

Primary (citable) accession number: Q1BY59

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program