Q1BY28 (AROA_BURCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Bcen_0566

Organism

Burkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]

Taxonomic identifier

331271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000012416

Sequences

	Sequence		Length	Mass (Da)
	Q1BY28 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 11A8BF62782CC1B4	FASTA	434	46,268
	10 20 30 40 50 60 MDYLDLGPYS SASGTVRLPG SKSISNRVLL LAALAEGETT ITNLLDSDDT RVMLDALGKL 70 80 90 100 110 120 GVKLARDGDT CVVTGTRGAF TAKTADLFLG NAGTAVRPLT AALAVNGGDY RVHGVPRMHE 130 140 150 160 170 180 RPIGDLVDGL RQIGAQIDYE LSEGYPPLRI KPATISVDAP IRVRGDVSSQ FLTALLMTLP 190 200 210 220 230 240 LVKAKDGQAV VEVDGELISK PYVDITIRLM ARFGVTVERD GWQRFVVPAG VRYRSPGRIM 250 260 270 280 290 300 VEGDASSASY FLAAGALGGG PLRVEGVGRA SIQGDVGFAN ALMQMGANVT MGDDWIDVRG 310 320 330 340 350 360 IGHDRGKLEP IDMDFNLIPD AAMTIAVAAL FANGTSTLRN IASWRVKETD RIAAMATELR 370 380 390 400 410 420 KVGAIVEEGP DYLVVTPPEK LTPNAAIDTY DDHRMAMCFS LVSLGGVPVR INDPKCVGKT 430 FPDYFDRFAA LAKA

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AU 1054.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000378 Genomic DNA. Translation: ABF75477.1.
RefSeq	YP_620450.1. NC_008060.1.
3D structure databases
ProteinModelPortal	Q1BY28.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1BY28.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4093797.
GenomeReviews	Gene locus Bcen_0566 in contig CP000378_GR.
KEGG	bcn:Bcen_0566.
PATRIC	19044605. VBIBurCen11237_0576.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	GADIEWG.
PhylomeDB	Q1BY28.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	BCEN331271:BCEN_0566-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_BURCA

Accession

Primary (citable) accession number: Q1BY28

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program