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Reviewed, UniProtKB/Swiss-Prot Q1BXP1 (ASTD_BURCA)

Last modified June 16, 2009. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD
Gene names
Name: astD
Ordered Locus Names: Bcen_0704
OrganismBurkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]
Taxonomic identifier331271 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length487 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process to glutamate

Inferred from electronic annotation. Source: HAMAP

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 487487N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_0000262387

Regions

Nucleotide binding221 – 2266NAD By similarity

Sites

Active site2441 By similarity
Active site2781 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1BXP1-1 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: D7DA5CEE6743CFCA

FASTA48751,721
        10         20         30         40         50         60 
MTELFIDGAW VAGSGPVFAS RNPGTDAVAW QGESASAADV DRAVASARRA FAGWSALDFE 

        70         80         90        100        110        120 
ARCEIVKRFA ALLTERKEAI ATAIGRETGK PLWEARTEVA SMAAKVGISI QAYQERTGEK 

       130        140        150        160        170        180 
RQDMADGVAV LRHRPHGVVA VFGPYNFPGH LPNGHIVPAL IAGNTVVFKP SELAPGVARA 

       190        200        210        220        230        240 
TVEVWQEAGL PAGVLNLVQG EKDTGIALAN HRQIDGLFFT GSSDTGTLLH KQFGGRPEIV 

       250        260        270        280        290        300 
LALEMGGNNP LVIGEVEDID AAVHHTIQSA FLSAGQRCTC ARRIFVPQGA FGDRFLARFA 

       310        320        330        340        350        360 
DVTSKITADV FDADPQPFMG AVISARAAAK LVDAQARLVE QGAKPIVAMA QRDPRLGFVN 

       370        380        390        400        410        420 
AAIVDVTGVA NLPDEEHFGP LAQVVRYATF DEAIERANDT AFGLSAGLLA DDAKVWEHFR 

       430        440        450        460        470        480 
RTIRAGIVNW NRPTNGASSA APFGGTGRSG NHRPSAYYAA DYCAYPMASV ESTQLTLPAS 


LSPGLHF 

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References

[1]"Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

CP000378 Genomic DNA. Translation: ABF75614.1.
RefSeqYP_620587.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID4092822.
GenomeReviewsGene locus Bcen_0704 in contig CP000378_GR.
KEGGbcn:Bcen_0704.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ1BXP1.
OMAQ1BXP1. EMTQPQA.

Enzyme and pathway databases

BioCycBCEN331271:BCEN_0704-MON.

Family and domain databases

HAMAPMF_01174.
[Tree]
InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03240. arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_BURCA
AccessionPrimary (citable) accession number: Q1BXP1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 11, 2006
Last modified: June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents