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Q1BXA8

- UPPP2_BURCA

UniProt

Q1BXA8 - UPPP2_BURCA

Protein

Undecaprenyl-diphosphatase 2

Gene

uppP2

Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBCEN331271:GHKX-862-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphatase 2UniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance protein 2UniRule annotation
    Undecaprenyl pyrophosphate phosphatase 2UniRule annotation
    Gene namesi
    Name:uppP2UniRule annotation
    Ordered Locus Names:Bcen_0838
    OrganismiBurkholderia cenocepacia (strain AU 1054)
    Taxonomic identifieri331271 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002400: Chromosome 1

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Undecaprenyl-diphosphatase 2PRO_0000250227Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi331271.Bcen_0838.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei44 – 6421HelicalUniRule annotationAdd
    BLAST
    Transmembranei87 – 10721HelicalUniRule annotationAdd
    BLAST
    Transmembranei114 – 13421HelicalUniRule annotationAdd
    BLAST
    Transmembranei150 – 17021HelicalUniRule annotationAdd
    BLAST
    Transmembranei190 – 21021HelicalUniRule annotationAdd
    BLAST
    Transmembranei222 – 24221HelicalUniRule annotationAdd
    BLAST
    Transmembranei251 – 27121HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiNANEAVD.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1BXA8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLWFLVFLS VLQGVTELFP VSSLGHTLLV PALFGMHIDK HAPQLLPFLV    50
    ALHLGTALAL LWYFRARWIA LIGGFFAQLG GRKNDDGHLM WALIIGTIPT 100
    GIVGLLLEKR IERVFHDLRI VAIALIVNGV LLWLGDRIQR SRAHQAPEKM 150
    TFKQAFFVGL AQIGALIPGF SRSGLTMIAG NVAGLTAEKA AEFSFLLGTP 200
    IIFAAGVLEL PKLFHARDQL ADALLGGVLT AIAAYLSVRF LMRYFEGRGR 250
    LASFGVYCVI AGVFCLGWFM LHPQPV 276
    Length:276
    Mass (Da):30,218
    Last modified:July 11, 2006 - v1
    Checksum:iA949403217C71907
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000378 Genomic DNA. Translation: ABF75747.1.
    RefSeqiYP_620720.1. NC_008060.1.

    Genome annotation databases

    EnsemblBacteriaiABF75747; ABF75747; Bcen_0838.
    GeneIDi4093813.
    KEGGibcn:Bcen_0838.
    PATRICi19045186. VBIBurCen11237_0859.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000378 Genomic DNA. Translation: ABF75747.1 .
    RefSeqi YP_620720.1. NC_008060.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331271.Bcen_0838.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF75747 ; ABF75747 ; Bcen_0838 .
    GeneIDi 4093813.
    KEGGi bcn:Bcen_0838.
    PATRICi 19045186. VBIBurCen11237_0859.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi NANEAVD.
    OrthoDBi EOG6QP13M.

    Enzyme and pathway databases

    BioCyci BCEN331271:GHKX-862-MONOMER.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AU 1054.

    Entry informationi

    Entry nameiUPPP2_BURCA
    AccessioniPrimary (citable) accession number: Q1BXA8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3