Reviewed, UniProtKB/Swiss-Prot Q1BX00 (IOLG_BURCA)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase
    EC=1.1.1.18
Alternative name(s):
    Myo-inositol 2-dehydrogenase
      Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Bcen_0946

Organism

Burkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]

Taxonomic identifier

331271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	337 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 337	337	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352560

Sequences

	Sequence		Length	Mass (Da)
	Q1BX00-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 915E9D19105493AB	FASTA	337	36,547
	10 20 30 40 50 60 MTLQIGVIGC GAIGQDHIRR LTRTLSGARV VAVNDIDPQQ ARDAVTKYGL DAEIYGDGHE 70 80 90 100 110 120 VVAAADVQAV LVTSWGPTHE AFVLDAIAHG KPVFCEKPLA VTAEGCMRIV EAEVAHGKRL 130 140 150 160 170 180 VQVGFMRPYD EGYRALKRVI DSGQIGAPLM LHCAHRNQSV GERYTTDMAI TDTLIHELDV 190 200 210 220 230 240 LRWLLGEDYA SAQVVYPKKT RHASAHLADP QIVLLETASG VRIDVEIFVN CQYGYDIQCE 250 260 270 280 290 300 VVGEQGIAKL PDPPAVGLKH AARQSVEIMT DWKERFIASY DVELQAFIDG VRQGALTGPS 310 320 330 AWDGYAAAVA ADACVRAQQS GAVEPIAMAE RPAFYRG

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000378 Genomic DNA. Translation: ABF75855.1.
RefSeq	YP_620828.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1BX00.
Genome annotation databases
GeneID	4093767.
GenomeReviews	Gene locus Bcen_0946 in contig CP000378_GR.
KEGG	bcn:Bcen_0946.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1BX00.
OMA	DWKDRFI.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_BURCA

Accession

Primary (citable) accession number: Q1BX00

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	July 11, 2006
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)