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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi386 – 393ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:Bcen_1695
OrganismiBurkholderia cenocepacia (strain AU 1054)
Taxonomic identifieri331271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002400 Componenti: Chromosome 1

Subcellular locationi

Q1BUV6:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei33 – 53HelicalUniRule annotationAdd BLAST21
Transmembranei75 – 95HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 157HelicalUniRule annotationAdd BLAST21
Transmembranei164 – 184HelicalUniRule annotationAdd BLAST21
Transmembranei262 – 282HelicalUniRule annotationAdd BLAST21
Transmembranei292 – 312HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002716161 – 593Lipid A export ATP-binding/permease protein MsbAAdd BLAST593

Proteomic databases

PRIDEiQ1BUV6.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1BUV6.
SMRiQ1BUV6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 320ABC transmembrane type-1UniRule annotationAdd BLAST285
Domaini352 – 586ABC transporterUniRule annotationAdd BLAST235

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK11085.
OMAiHERVQGM.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1BUV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQNTLRKP MDGTGTSPMT VLKRLWPYIR PLIGIVVLAV VTMGVVAATE
60 70 80 90 100
AGIPALLKPL LDHGFGSHGS DSAKWYVPIA VIGLALVRGV SQYTSNYLLN
110 120 130 140 150
YVSNRILLQL RLEMFQRMIH TGASFFQRET ASTVINAIVF EVNQILSVLT
160 170 180 190 200
GVMVTLVRDS LTVIFLLGYL FYLNWRLTLI VAVILPGIGW LVSKINRRLR
210 220 230 240 250
RLNREHQTLT NELSYIVEET VGGYKVVKVH NGEAYEMDRF TTMSKRLRGY
260 270 280 290 300
AMRMTISGGL AQPLTQFLAS IALAVVITIA VVQSSNDQTT VGGFVAFVTS
310 320 330 340 350
MLLVISPLKH LIDVNQPLQR GMTAAELIFG LIDEPAEPQG GGRPLSQARG
360 370 380 390 400
EIEFRAVSFD YGAAERPTLD RISFKVAPGE MIALAGPSGS GKTTLVNLLP
410 420 430 440 450
RFFDPTDGTI LVDGVPVSDY DLHALRSQMA MVSQDVVLFN DTIAANVAYG
460 470 480 490 500
QTPDRARVQA ALEAANLADA VAAMPDGLDT LVGGNGMRLS GGQRQRLAIA
510 520 530 540 550
RAIYKDAPIL ILDEATSALD SESERHVQAA LERLMEGRTT LVIAHRLSTI
560 570 580 590
ERADRILVLE AGKIVEEGSH DELLRHGGLY AHLHRIQYQQ QAA
Length:593
Mass (Da):64,792
Last modified:January 9, 2007 - v2
Checksum:i47F6E241E33E1969
GO

Sequence cautioni

Q1BUV6: The sequence ABF76599 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000378 Genomic DNA. Translation: ABF76599.1. Different initiation.

Genome annotation databases

EnsemblBacteriaiABF76599; ABF76599; Bcen_1695.
KEGGibcn:Bcen_1695.

Similar proteinsi

Entry informationi

Entry nameiMSBA_BURCA
AccessioniPrimary (citable) accession number: Q1BUV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 25, 2017
This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families