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Q1BTP1 (SYD_BURCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aspartate--tRNA ligase

EC=6.1.1.12
Alternative name(s):
Aspartyl-tRNA synthetase
Short name=AspRS
Gene names
Name:aspS
Ordered Locus Names:Bcen_2113
OrganismBurkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]
Taxonomic identifier331271 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP-Rule MF_00044

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00044

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00044.

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaspartyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aspartate-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleic acid binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Aspartate--tRNA ligase HAMAP-Rule MF_00044
PRO_1000006644

Sequences

Sequence LengthMass (Da)Tools
Q1BTP1 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 4FDAD415B483C6AF

FASTA60067,757
        10         20         30         40         50         60 
MSMRTEYCGL VTEHLLGQTV SLCGWVQRRR DHGGVIFIDL RDREGLVQVV CDPDRAEMFA 

        70         80         90        100        110        120 
TAEGVRNEFC VQIKGLVRNR PDGTVNAGLK SGRIEVLCHE LNVLNASVTP PFQLDDDNLS 

       130        140        150        160        170        180 
ETTRLTHRVL DLRRPQMQHN LRLRYRVAIE ARKYLDEQGF IDIETPMLTK STPEGARDYL 

       190        200        210        220        230        240 
VPSRVNAGQF FALPQSPQLF KQLLMVANFD RYYQITKCFR DEDLRADRQP EFTQIDCETS 

       250        260        270        280        290        300 
FLGEQEIRDL FEDMIRHIFK TTIDVELDAK FPVMPYSEAM ARFGSDKPDL RVQLEFTELT 

       310        320        330        340        350        360 
DAMKDVDFKV FSTPANAKDG RVAALRVPKG GELSRGDIDG YTEFVRIYGA KGLAWIKVNE 

       370        380        390        400        410        420 
KAKGRDGLQS PIVKNLHDAS IAAILERTGA EDGDIIFFAA DRAKVVNDSL GALRLKIGHS 

       430        440        450        460        470        480 
EFGKANGLVQ AGWKPLWVVD FPMFEYDDED ARYVAAHHPF TSPKDEHLEY LETDPGRCLA 

       490        500        510        520        530        540 
KAYDMVLNGW EIGGGSVRIH REEVQSKVFR ALKIGAEEAQ LKFGFLLDAL QYGAPPHGGI 

       550        560        570        580        590        600 
AFGLDRIVTM MAGADSIRDV IAFPKTQRAQ DLLTQAPSPV DERQLRELHI RLRQPEQPKA 

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AU 1054.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000378 Genomic DNA. Translation: ABF77014.1.
RefSeqYP_621987.1. NC_008060.1.

3D structure databases

ProteinModelPortalQ1BTP1.
SMRQ1BTP1. Positions 3-593.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING331271.Bcen_2113.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF77014; ABF77014; Bcen_2113.
GeneID4091123.
KEGGbcn:Bcen_2113.
PATRIC19047917. VBIBurCen11237_2202.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0173.
HOGENOMHOG000275160.
KOK01876.
OMAQLDVEMS.
OrthoDBEOG68Q0NX.
ProtClustDBPRK00476.

Enzyme and pathway databases

BioCycBCEN331271:GHKX-2159-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
3.30.1360.30. 1 hit.
HAMAPMF_00044_B. Asp_tRNA_synth_B.
InterProIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004524. Asp-tRNA-ligase_IIb_bac/mt.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR004115. GAD_dom.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF5. PTHR22594:SF5. 1 hit.
PfamPF02938. GAD. 1 hit.
PF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSPR01042. TRNASYNTHASP.
SUPFAMSSF50249. SSF50249. 1 hit.
SSF55261. SSF55261. 1 hit.
TIGRFAMsTIGR00459. aspS_bact. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYD_BURCA
AccessionPrimary (citable) accession number: Q1BTP1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries