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Q1BTA5

- Q1BTA5_BURCA

UniProt

Q1BTA5 - Q1BTA5_BURCA

Protein

Glutathione synthetase

Gene

gshB

Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi285 – 2851Magnesium or manganeseUniRule annotation
    Metal bindingi287 – 2871Magnesium or manganeseUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi155 – 21157ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. glutathione synthase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP
    4. manganese ion binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Glutathione biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBCEN331271:GHKX-2296-MONOMER.
    UniPathwayiUPA00142; UER00210.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione synthetaseUniRule annotation (EC:6.3.2.3UniRule annotation)
    Alternative name(s):
    GSH synthetaseUniRule annotation
    Glutathione synthaseUniRule annotation
    Gene namesi
    Name:gshBUniRule annotation
    Ordered Locus Names:Bcen_2249Imported
    OrganismiBurkholderia cenocepacia (strain AU 1054)Imported
    Taxonomic identifieri331271 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
    ProteomesiUP000002400: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi331271.Bcen_2249.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1BTA5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini129 – 314186ATP-graspUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the prokaryotic GSH synthase family.UniRule annotation
    Contains 1 ATP-grasp domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0189.
    HOGENOMiHOG000265022.
    KOiK01920.
    OMAiDWKIARA.
    OrthoDBiEOG6WMHWB.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPiMF_00162. GSH_S.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006284. Glut_synth_pro.
    IPR004218. GSHS_ATP-bd.
    IPR004215. GSHS_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view]
    PfamiPF02955. GSH-S_ATP. 1 hit.
    PF02951. GSH-S_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR01380. glut_syn. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1BTA5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDILFIADPL DHFKIYKDST YAMMAEAARR GHAVYAGEPR HLAWTGSAVE    50
    ADVRRITFVG ELDDLHRDTW FEAGPVDARR LESFGAVLMR KDPPFDMEYV 100
    TSTWLLELAE RAGARVFNKA QSIRDHSEKL AIGEFPQFVA PTLVTRDAKR 150
    LRAFHAEHGD VILKPLDGMG GMGVFRVKPD GMNLGSIVEM LSHDRTRSVM 200
    AQKFIPEIKA GDKRILLIGG EPVPYSLARI PQGSEVRGNL AAGGLGVAQP 250
    LTARDREIAD TLGPVLASRG LLLVGLDAIG DWLTEVNVTS PTCFREIMEQ 300
    TGFDVAAMFI DALERAAA 318
    Length:318
    Mass (Da):34,943
    Last modified:July 11, 2006 - v1
    Checksum:i5F07D34AECEE48DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000378 Genomic DNA. Translation: ABF77150.1.
    RefSeqiYP_622123.1. NC_008060.1.

    Genome annotation databases

    EnsemblBacteriaiABF77150; ABF77150; Bcen_2249.
    GeneIDi4092991.
    KEGGibcn:Bcen_2249.
    PATRICi19048209. VBIBurCen11237_2348.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000378 Genomic DNA. Translation: ABF77150.1 .
    RefSeqi YP_622123.1. NC_008060.1.

    3D structure databases

    ProteinModelPortali Q1BTA5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 331271.Bcen_2249.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABF77150 ; ABF77150 ; Bcen_2249 .
    GeneIDi 4092991.
    KEGGi bcn:Bcen_2249.
    PATRICi 19048209. VBIBurCen11237_2348.

    Phylogenomic databases

    eggNOGi COG0189.
    HOGENOMi HOG000265022.
    KOi K01920.
    OMAi DWKIARA.
    OrthoDBi EOG6WMHWB.

    Enzyme and pathway databases

    UniPathwayi UPA00142 ; UER00210 .
    BioCyci BCEN331271:GHKX-2296-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    HAMAPi MF_00162. GSH_S.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR006284. Glut_synth_pro.
    IPR004218. GSHS_ATP-bd.
    IPR004215. GSHS_N.
    IPR016185. PreATP-grasp_dom.
    [Graphical view ]
    Pfami PF02955. GSH-S_ATP. 1 hit.
    PF02951. GSH-S_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR01380. glut_syn. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AU 1054Imported.

    Entry informationi

    Entry nameiQ1BTA5_BURCA
    AccessioniPrimary (citable) accession number: Q1BTA5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 11, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3