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Q1BTA5 (Q1BTA5_BURCA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutathione synthetase HAMAP-Rule MF_00162

EC=6.3.2.3 HAMAP-Rule MF_00162
Alternative name(s):
GSH synthetase HAMAP-Rule MF_00162
Glutathione synthase HAMAP-Rule MF_00162
Gene names
Name:gshB HAMAP-Rule MF_00162
Ordered Locus Names:Bcen_2249 EMBL ABF77150.1
OrganismBurkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP] EMBL ABF77150.1
Taxonomic identifier331271 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione. HAMAP-Rule MF_00162

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. HAMAP-Rule MF_00162

Pathway

Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. HAMAP-Rule MF_00162

Sequence similarities

Belongs to the prokaryotic GSH synthase family. HAMAP-Rule MF_00162

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00162

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain129 – 314186ATP-grasp By similarity HAMAP-Rule MF_00162
Nucleotide binding155 – 21157ATP By similarity HAMAP-Rule MF_00162

Sites

Metal binding2851Magnesium or manganese By similarity HAMAP-Rule MF_00162
Metal binding2871Magnesium or manganese By similarity HAMAP-Rule MF_00162

Sequences

Sequence LengthMass (Da)Tools
Q1BTA5 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 5F07D34AECEE48DF

FASTA31834,943
        10         20         30         40         50         60 
MDILFIADPL DHFKIYKDST YAMMAEAARR GHAVYAGEPR HLAWTGSAVE ADVRRITFVG 

        70         80         90        100        110        120 
ELDDLHRDTW FEAGPVDARR LESFGAVLMR KDPPFDMEYV TSTWLLELAE RAGARVFNKA 

       130        140        150        160        170        180 
QSIRDHSEKL AIGEFPQFVA PTLVTRDAKR LRAFHAEHGD VILKPLDGMG GMGVFRVKPD 

       190        200        210        220        230        240 
GMNLGSIVEM LSHDRTRSVM AQKFIPEIKA GDKRILLIGG EPVPYSLARI PQGSEVRGNL 

       250        260        270        280        290        300 
AAGGLGVAQP LTARDREIAD TLGPVLASRG LLLVGLDAIG DWLTEVNVTS PTCFREIMEQ 

       310 
TGFDVAAMFI DALERAAA 

« Hide

References

[1]"Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AU 1054 EMBL ABF77150.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000378 Genomic DNA. Translation: ABF77150.1.
RefSeqYP_622123.1. NC_008060.1.

3D structure databases

ProteinModelPortalQ1BTA5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING331271.Bcen_2249.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABF77150; ABF77150; Bcen_2249.
GeneID4092991.
KEGGbcn:Bcen_2249.
PATRIC19048209. VBIBurCen11237_2348.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0189.
HOGENOMHOG000265022.
KOK01920.
OMADWKIARA.
OrthoDBEOG6WMHWB.

Enzyme and pathway databases

BioCycBCEN331271:GHKX-2296-MONOMER.
UniPathwayUPA00142; UER00210.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00162. GSH_S.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR006284. Glut_synth_pro.
IPR004218. GSHS_ATP-bd.
IPR004215. GSHS_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PfamPF02955. GSH-S_ATP. 1 hit.
PF02951. GSH-S_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01380. glut_syn. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1BTA5_BURCA
AccessionPrimary (citable) accession number: Q1BTA5
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)