Reviewed, UniProtKB/Swiss-Prot Q1BRZ3 (AROB_BURCA)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	Bcen_2714

Organism

Burkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]

Taxonomic identifier

331271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. NAD By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000094469

Sequences

	Sequence		Length	Mass (Da)
	Q1BRZ3-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: D6E78637CDD1F046	FASTA	359	37,865
	10 20 30 40 50 60 MITVNVDLGD RAYPIHIGAG LIGRTELFAP HIKGSSVTIV TNTTVDPLYG DALRAALAPL 70 80 90 100 110 120 GKRVSTVVLP DGEAYKNWET LNLIFDGLLT DHADRKTTLV ALGGGVVGDM TGFAAACYMR 130 140 150 160 170 180 GVPFIQVPTT LLSQVDSSVG GKTGINHPLG KNMIGAFYQP QAVIADIGAL TTLPDRELAA 190 200 210 220 230 240 GVAEVIKTGA IADAGFFDWI EANVEALNRR EPAALAHAVK RSCEIKASVV AADEREGGLR 250 260 270 280 290 300 AILNFGHTFG HAIEAGLGYG EWLHGEAVGC GMVMAGDLSV RLGLLDEASR QRLDAVIAAA 310 320 330 340 350 HLPTRGPALG DARYMDLMRV DKKAEAGAIK FILLKRFGDT LITQAPDEAV FATLAQTTR

References

[1]

"Complete sequence of chromosome 1 of Burkholderia cenocepacia AU 1054." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000378 Genomic DNA. Translation: ABF77612.1.
RefSeq	YP_622585.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1BRZ3.
Genome annotation databases
GeneID	4091466.
GenomeReviews	Gene locus Bcen_2714 in contig CP000378_GR.
KEGG	bcn:Bcen_2714.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1BRZ3.
OMA	EDYLPHM.
Enzyme and pathway databases
BioCyc	BCEN331271:BCEN_2714-MON.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BURCA

Accession

Primary (citable) accession number: Q1BRZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 11, 2006
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)