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Q1BR24

- GCH41_BURCA

UniProt

Q1BR24 - GCH41_BURCA

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Protein

GTP cyclohydrolase FolE2 1

Gene

folE2-1

Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei166 – 1661May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBCEN331271:GHKX-3104-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2-1UniRule annotation
Ordered Locus Names:Bcen_3035
OrganismiBurkholderia cenocepacia (strain AU 1054)
Taxonomic identifieri331271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002400: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316GTP cyclohydrolase FolE2 1PRO_0000289476Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331271.Bcen_3035.

Structurei

3D structure databases

ProteinModelPortaliQ1BR24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000247517.
KOiK09007.
OMAiAGRTTIQ.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1BR24 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKALHRISS MNAALPDISL TDAAPGRRPL EWVGMQGIDL PVVVAEPGCR
60 70 80 90 100
RDVHARADVQ VDLPAPQVKG IHMSRLYGLL DGLADGEALS PAGLQRMLRA
110 120 130 140 150
MVDSHRDCET RSARVRLRFD LLARRTALVT EGLAGWKAYP VRLDATLAGD
160 170 180 190 200
AFALRAQVTV VYSSTCPCSA ALSRHWIEQA FLTAFGHEAR VEPTAVAAWL
210 220 230 240 250
KRHAMAATPH SQRSEAVVSV ALPADGTTLG LLDLIDRVEQ ALGTPVQTAV
260 270 280 290 300
KRADEQAFAV LNGGNLMFVE DAARRVQAAL EDRHASPRVR VRHLESLHPH
310
DAVAWAAPLR EGADAC
Length:316
Mass (Da):34,188
Last modified:July 11, 2006 - v1
Checksum:i4152523B461CBCE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000379 Genomic DNA. Translation: ABF77931.1.
RefSeqiYP_622904.1. NC_008061.1.

Genome annotation databases

EnsemblBacteriaiABF77931; ABF77931; Bcen_3035.
GeneIDi4096162.
KEGGibcn:Bcen_3035.
PATRICi19049888. VBIBurCen11237_3165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000379 Genomic DNA. Translation: ABF77931.1 .
RefSeqi YP_622904.1. NC_008061.1.

3D structure databases

ProteinModelPortali Q1BR24.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331271.Bcen_3035.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF77931 ; ABF77931 ; Bcen_3035 .
GeneIDi 4096162.
KEGGi bcn:Bcen_3035.
PATRICi 19049888. VBIBurCen11237_3165.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000247517.
KOi K09007.
OMAi AGRTTIQ.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci BCEN331271:GHKX-3104-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AU 1054.

Entry informationi

Entry nameiGCH41_BURCA
AccessioniPrimary (citable) accession number: Q1BR24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3