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Protein

2-aminoethylphosphonate--pyruvate transaminase

Gene

phnW

Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in phosphonate degradation.UniRule annotation

Catalytic activityi

(2-aminoethyl)phosphonate + pyruvate = 2-phosphonoacetaldehyde + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate, Pyruvate

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminoethylphosphonate--pyruvate transaminaseUniRule annotation (EC:2.6.1.37UniRule annotation)
Alternative name(s):
2-aminoethylphosphonate aminotransferaseUniRule annotation
AEP transaminaseUniRule annotation
Short name:
AEPTUniRule annotation
Gene namesi
Name:phnWUniRule annotation
Ordered Locus Names:Bcen_3066
OrganismiBurkholderia cenocepacia (strain AU 1054)
Taxonomic identifieri331271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000002400 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002867611 – 3692-aminoethylphosphonate--pyruvate transaminaseAdd BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei191N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1BQZ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000171816.
KOiK03430.
OMAiSHHCVPL.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01376. PhnW_aminotrans_5. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR012703. NH2EtPonate_pyrv_transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03301. PhnW-AepZ. 1 hit.
TIGR02326. transamin_PhnW. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1BQZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPILLTPG PLTTSATTRH AMQHDWGSWD AAFNQLTASV CADLVAIAHG
60 70 80 90 100
GDEYVCVPMQ GSGTFSVEAA LGTLVPRDGV VLVPDNGAYC ARILKILGRL
110 120 130 140 150
GIDAIALPFG EDAAVDAAAV EAAFAREPRI THVALVHLET SAGILNPLDA
160 170 180 190 200
IAAACRRHGK RLIVDAMSSF GALPIALADS GIDALISASG KCLEGVPGMG
210 220 230 240 250
FAIVRRDALD ASEGNSPSLA LDLHDQYAYL RKTGQWRFTP PTHVIAALRA
260 270 280 290 300
ALDQYLAEGG QPARGARYAD NCRTLVESMR ALGFVPFLDA SVQAPVIVTF
310 320 330 340 350
HAPDHPAYDF RRFYDAVRGA GFILYPGKLT RLETFRVGCI GAIDAGDIRR
360
AVAAIGAAVE SLGIAMQPA
Length:369
Mass (Da):38,778
Last modified:July 11, 2006 - v1
Checksum:i1696F6DB385C22E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000379 Genomic DNA. Translation: ABF77962.1.
RefSeqiWP_011546896.1. NC_008061.1.

Genome annotation databases

EnsemblBacteriaiABF77962; ABF77962; Bcen_3066.
KEGGibcn:Bcen_3066.
PATRICi19049952. VBIBurCen11237_3197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000379 Genomic DNA. Translation: ABF77962.1.
RefSeqiWP_011546896.1. NC_008061.1.

3D structure databases

ProteinModelPortaliQ1BQZ3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABF77962; ABF77962; Bcen_3066.
KEGGibcn:Bcen_3066.
PATRICi19049952. VBIBurCen11237_3197.

Phylogenomic databases

HOGENOMiHOG000171816.
KOiK03430.
OMAiSHHCVPL.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01376. PhnW_aminotrans_5. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR012703. NH2EtPonate_pyrv_transaminase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR024169. SP_NH2Trfase/AEP_transaminase.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF000524. SPT. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03301. PhnW-AepZ. 1 hit.
TIGR02326. transamin_PhnW. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPHNW_BURCA
AccessioniPrimary (citable) accession number: Q1BQZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 11, 2006
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

The second enzyme involved in phosphonate degradation (PhnX, EC 3.11.1.1) is not found in this organism. The function of this enzyme is therefore uncertain.Curated

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.