Q1BM14 (Q1BM14_BURCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109
EC=1.1.1.44 PIRNR PIRNR000109

Gene names

Ordered Locus Names:

Bcen_4459

Organism

Burkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP] EMBL ABF79341.1

Taxonomic identifier

331271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109
Catalytic activity	6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109
Subunit structure	Homodimer By similarity. PIRNR PIRNR000109
Sequence similarities	Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109

Ontologies

Keywords
Biological process	Pentose shunt PIRNR PIRNR000109
Ligand	NADP PIRNR PIRNR000109
Molecular function	Oxidoreductase PIRNR PIRNR000109 EMBL ABF79341.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-gluconate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro phosphogluconate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	10 – 15	6	NADP By similarity PIRSR PIRSR000109-3
	Nucleotide binding	33 – 35	3	NADP By similarity PIRSR PIRSR000109-3
	Nucleotide binding	74 – 76	3	NADP By similarity PIRSR PIRSR000109-3
	Region	128 – 130	3	Substrate binding By similarity PIRSR PIRSR000109-2
	Region	187 – 188	2	Substrate binding By similarity PIRSR PIRSR000109-2
Sites
	Active site	184	1	Proton acceptor By similarity PIRSR PIRSR000109-1
	Active site	191	1	Proton donor By similarity PIRSR PIRSR000109-1
	Binding site	102	1	NADP By similarity PIRSR PIRSR000109-3
	Binding site	102	1	Substrate By similarity PIRSR PIRSR000109-2
	Binding site	192	1	Substrate By similarity PIRSR PIRSR000109-2
	Binding site	262	1	Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
	Binding site	289	1	Substrate By similarity PIRSR PIRSR000109-2
	Binding site	448	1	Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
	Binding site	454	1	Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

	Sequence		Length	Mass (Da)
	Q1BM14 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 0BDC58CA96722195	FASTA	470	50,944
	10 20 30 40 50 60 MGKQAIGVIG LAVMGRNLAL NIESRGYAVS VFNRSREKTD ELIAEFPGRN LVPTYTLEEF 70 80 90 100 110 120 VASLETPRRI LMMVKAGEAT DATIASLKPL LEKGDVLIDG GNTHFTDTIR RNQELAQSGL 130 140 150 160 170 180 HFIGTGVSGG EEGALRGPSI MPGGQRDAYD LVEPILKQIA AKAPSDGEPC VAYMGPDGAG 190 200 210 220 230 240 HYVKMVHNGI EYGDMQLIAE SYSVLKDVAG LTNDELGAVY TEWNQGELDS YLIEITSKIF 250 260 270 280 290 300 GKKDEETGKH LVDVILDRAA QKGTGKWTSQ NALDLGVPLP LITESVFARV LSSLKTERVA 310 320 330 340 350 360 ASKILSGPAA APFDGDRAAF VEAVRRALYL SKVISYAQGF AQLRTASEEY GWNLDLGTIA 370 380 390 400 410 420 KIFRAGCIIR ARFLQKITDA YAKDPALANL LLDPYFKDIA ANYQTALRDV VVAAVKAGVP 430 440 450 460 470 VPAFASAVAY FDSYRSERLP ANLVQAQRDF FGAHTFERTD KPGSFHANWS

References

[1]

"Complete sequence of chromosome 2 of Burkholderia cenocepacia AU 1054." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AU 1054.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000379 Genomic DNA. Translation: ABF79341.1.
RefSeq	YP_624314.1. NC_008061.1.
3D structure databases
ProteinModelPortal	Q1BM14.
SMR	Q1BM14. Positions 7-469.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1BM14.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4094674.
GenomeReviews	Gene locus Bcen_4459 in contig CP000379_GR.
KEGG	bcn:Bcen_4459.
PATRIC	19052880. VBIBurCen11237_4649.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0362.
HOGENOM	HBG286913.
OMA	MEHNEMA.
PhylomeDB	Q1BM14.
ProtClustDB	PRK09287.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR006114. 6PGDH_C. IPR006113. 6PGDH_decarbox. IPR006115. 6PGDH_NADP-bd. IPR006184. 6PGdom_BS. IPR013328. DH_multihelical. IPR012284. Fibritin/6PGD_C-extension. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00033.
Pfam	PF00393. 6PGD. 1 hit. PF03446. NAD_binding_2. 1 hit. [Graphical view]
PIRSF	PIRSF000109. 6PGD. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00873. Gnd. 1 hit.
PROSITE	PS00461. 6PGD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1BM14_BURCA

Accession

Primary (citable) accession number: Q1BM14

Entry history

Integrated into UniProtKB/TrEMBL:	July 11, 2006
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)