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Q1BLX6 (KHSE_BURCA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:Bcen_4497
OrganismBurkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]
Taxonomic identifier331271 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301

Sequence similarities

Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Homoserine kinase HAMAP MF_00301
PRO_0000300784

Sequences

Sequence LengthMass (Da)Tools
Q1BLX6 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: CA5E3D0BD59F3755

FASTA33237,186
        10         20         30         40         50         60 
MAVFTAVSDS DLAQWMRHYE LGDVLAFRGI PSGIENSNFF LTTTRGEYVL TIFEKLTAQQ 

        70         80         90        100        110        120 
LPFYLDLMRH LAAHGVPVPD PIPRDDGALF GELHGKPAAI VTKLDGAAEL APGVEHCIEV 

       130        140        150        160        170        180 
GQMLARLHLA GRDYPRNQPN LRSLPWWQEN VPAIVPFITD AQRALLEGEL AHQAGFFASD 

       190        200        210        220        230        240 
DYAALPAGPC HCDLFRDNVL FAHAAPGTGH DVRLGGFFDF YFAGCDKWLF DVAVTVNDWC 

       250        260        270        280        290        300 
VDLATGVLDV ARADALLRAY QTVRPFTAEE RRHWSDMLRA GAYRFWVSRL YDFYLPRAAE 

       310        320        330 
MLKPHDPGHF ERILRERIAH TPALPEIQTA CN

« Hide

References

[1]"Complete sequence of chromosome 2 of Burkholderia cenocepacia AU 1054."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. expand/collapse author list , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P.
Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AU 1054.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000379 Genomic DNA. Translation: ABF79379.1.
RefSeqYP_624352.1. NC_008061.1.

3D structure databases

ProteinModelPortalQ1BLX6.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1BLX6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4094468.
GenomeReviewsGene locus Bcen_4497 in contig CP000379_GR.
KEGGbcn:Bcen_4497.
PATRIC19052970. VBIBurCen11237_4692.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2334.
HOGENOMHBG309377.
OMAICLNAWC.
ProtClustDBPRK05231.

Enzyme and pathway databases

BioCycBCEN331271:BCEN_4497-MONOMER.

Family and domain databases

HAMAPMF_00301. Homoser_kinase_2.
[Tree]
InterProIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
KOK02204.
PfamPF01636. APH. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
TIGRFAMsTIGR00938. ThrB_alt. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKHSE_BURCA
AccessionPrimary (citable) accession number: Q1BLX6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 11, 2006
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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