Q1BHH2 (LPXD_BURCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	Bcen_6068

Organism

Burkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]

Taxonomic identifier

331271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523		PRO_0000264350
Sites
	Active site	258	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1BHH2 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 90965A600517982E	FASTA	364	37,152
	10 20 30 40 50 60 MALTLEELVK RFGGEIAGDA QCKVGGLAPL DQAGPQQLAF LANPKYLSQV ESTRAGAVLI 70 80 90 100 110 120 APKDLEKLGA AAQGRTAGPR NFIVTPNPYA YFARVAQMFI DLATPPRAAG VHPSATIDPA 130 140 150 160 170 180 AKVAATAVIG PHVTIEAGAV IEDGVQLDAN VFVGRGTTIG AGSHFYPNAS VYHGCKVGPR 190 200 210 220 230 240 AIVHAGAVIG SDGFGFAPDF VGDGDARTGS WVKIPQVGGV TIGPDVEIGA NTTIDRGAMA 250 260 270 280 290 300 DTVIEECVKI DNQVQIGHNC RIGAYTVIAG SAGIAGSTTI GRHCMIGGAA GIAGHVTLGD 310 320 330 340 350 360 YVIITAKSGV SKSLPKAGIY TSAFPAVDHG EWNKSAALVR NLDKLRERIK ALEAALAAQG GTDA

References

[1]

"Complete sequence of chromosome 3 of Burkholderia cenocepacia AU 1054." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AU 1054.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000380 Genomic DNA. Translation: ABF80933.1.
RefSeq	YP_625906.1. NC_008062.1.
3D structure databases
ProteinModelPortal	Q1BHH2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1BHH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4097236.
GenomeReviews	Gene locus Bcen_6068 in contig CP000380_GR.
KEGG	bcn:Bcen_6068.
PATRIC	19056178. VBIBurCen11237_6274.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1044.
HOGENOM	HBG469615.
OMA	CFVGKNT.
PhylomeDB	Q1BHH2.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	BCEN331271:BCEN_6068-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 6 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 3 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_BURCA

Accession

Primary (citable) accession number: Q1BHH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program