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Q1BHG9

- LPXB_BURCA

UniProt

Q1BHG9 - LPXB_BURCA

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBCEN331271:GHKX-6165-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Bcen_6071
OrganismiBurkholderia cenocepacia (strain AU 1054)
Taxonomic identifieri331271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002400: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Lipid-A-disaccharide synthasePRO_0000255163Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331271.Bcen_6071.

Structurei

3D structure databases

ProteinModelPortaliQ1BHG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1BHG9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLPTNQLRL AMVAGEPSGD LLAASLLGGL RERLPESAQY YGIGGQRMIA
60 70 80 90 100
QGFDSHWQMD KLTVRGYVEA LGQIPEILRI RGELKRQLLA ERPAAFIGVD
110 120 130 140 150
APDFNFNVEQ AARDAGIPSI HFVCPSIWAW RGGRIKKIAK SVDHMLCLFP
160 170 180 190 200
FEPAILDKAG VASTYVGHPL ADDIPLEPDT HGARIALGLP ADGPVIAVLP
210 220 230 240 250
GSRRSEIALI GPTFFAAMAL MQQREPGVRF VMPAATPALR ELLQPLVDAH
260 270 280 290 300
PQLALTITDG RSQVAMTAAD AILVKSGTVT LEAALLKKPM VISYKVPWLT
310 320 330 340 350
GQIMRRQGYL PYVGLPNILA GRFVVPELLQ HFATPEALAD ATLTQLSDDA
360 370 380
NRRTLTEVFT EMHLSLRQNT AAKAAEAVVR VLEQRKGRA
Length:389
Mass (Da):42,259
Last modified:July 11, 2006 - v1
Checksum:i380F666EDD039534
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000380 Genomic DNA. Translation: ABF80936.1.
RefSeqiYP_625909.1. NC_008062.1.

Genome annotation databases

EnsemblBacteriaiABF80936; ABF80936; Bcen_6071.
GeneIDi4097239.
KEGGibcn:Bcen_6071.
PATRICi19056184. VBIBurCen11237_6277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000380 Genomic DNA. Translation: ABF80936.1 .
RefSeqi YP_625909.1. NC_008062.1.

3D structure databases

ProteinModelPortali Q1BHG9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331271.Bcen_6071.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF80936 ; ABF80936 ; Bcen_6071 .
GeneIDi 4097239.
KEGGi bcn:Bcen_6071.
PATRICi 19056184. VBIBurCen11237_6277.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BCEN331271:GHKX-6165-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AU 1054.

Entry informationi

Entry nameiLPXB_BURCA
AccessioniPrimary (citable) accession number: Q1BHG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 11, 2006
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3