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Q1BHG9

- LPXB_BURCA

UniProt

Q1BHG9 - LPXB_BURCA

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Bcen_6071
Organism
Burkholderia cenocepacia (strain AU 1054)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBCEN331271:GHKX-6165-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Bcen_6071
OrganismiBurkholderia cenocepacia (strain AU 1054)
Taxonomic identifieri331271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
ProteomesiUP000002400: Chromosome 3

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Lipid-A-disaccharide synthaseUniRule annotation
PRO_0000255163Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi331271.Bcen_6071.

Structurei

3D structure databases

ProteinModelPortaliQ1BHG9.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1BHG9-1 [UniParc]FASTAAdd to Basket

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MPLPTNQLRL AMVAGEPSGD LLAASLLGGL RERLPESAQY YGIGGQRMIA    50
QGFDSHWQMD KLTVRGYVEA LGQIPEILRI RGELKRQLLA ERPAAFIGVD 100
APDFNFNVEQ AARDAGIPSI HFVCPSIWAW RGGRIKKIAK SVDHMLCLFP 150
FEPAILDKAG VASTYVGHPL ADDIPLEPDT HGARIALGLP ADGPVIAVLP 200
GSRRSEIALI GPTFFAAMAL MQQREPGVRF VMPAATPALR ELLQPLVDAH 250
PQLALTITDG RSQVAMTAAD AILVKSGTVT LEAALLKKPM VISYKVPWLT 300
GQIMRRQGYL PYVGLPNILA GRFVVPELLQ HFATPEALAD ATLTQLSDDA 350
NRRTLTEVFT EMHLSLRQNT AAKAAEAVVR VLEQRKGRA 389
Length:389
Mass (Da):42,259
Last modified:July 11, 2006 - v1
Checksum:i380F666EDD039534
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000380 Genomic DNA. Translation: ABF80936.1.
RefSeqiYP_625909.1. NC_008062.1.

Genome annotation databases

EnsemblBacteriaiABF80936; ABF80936; Bcen_6071.
GeneIDi4097239.
KEGGibcn:Bcen_6071.
PATRICi19056184. VBIBurCen11237_6277.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000380 Genomic DNA. Translation: ABF80936.1 .
RefSeqi YP_625909.1. NC_008062.1.

3D structure databases

ProteinModelPortali Q1BHG9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 331271.Bcen_6071.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABF80936 ; ABF80936 ; Bcen_6071 .
GeneIDi 4097239.
KEGGi bcn:Bcen_6071.
PATRICi 19056184. VBIBurCen11237_6277.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BCEN331271:GHKX-6165-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AU 1054.

Entry informationi

Entry nameiLPXB_BURCA
AccessioniPrimary (citable) accession number: Q1BHG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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