Reviewed, UniProtKB/Swiss-Prot Q1BH71 (MSRB_BURCA)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrB
    EC=1.8.4.12
Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	Bcen_6170

Organism

Burkholderia cenocepacia (strain AU 1054) [Complete proteome] [HAMAP]

Taxonomic identifier

331271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	143 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity. HAMAP MF_01400
Sequence similarities	Belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 143	143	Peptide methionine sulfoxide reductase msrB HAMAP MF_01400		PRO_1000145351
Sites
	Active site	128	1	Nucleophile By similarity
	Metal binding	55	1	Zinc By similarity
	Metal binding	58	1	Zinc By similarity
	Metal binding	104	1	Zinc By similarity
	Metal binding	107	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1BH71-1 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 838E9BC10B0CD2AF	FASTA	143	16,193
	10 20 30 40 50 60 MSHDSDDKTF PYQKDDAELR RRLTPMQYEV TQHAATERAF TGEYTDTEDA GIYKCVVCST 70 80 90 100 110 120 PLFESGAKFH SGCGWPSYFK PLNGEVIDEK VDYSHGMVRV EVRCNNCGAH LGHVFEDGPR 130 140 DKTGLRYCIN SAALNFESRP ENE

References

[1]

"Complete sequence of chromosome 3 of Burkholderia cenocepacia AU 1054." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M. , Hauser L., Kyrpides N., Lykidis A., LiPuma J.J., Konstantinidis K., Tiedje J.M., Richardson P. Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000380 Genomic DNA. Translation: ABF81034.1.
RefSeq	YP_626007.1.
3D structure databases
SMR	Q1BH71. Positions 10-140.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1BH71.
Genome annotation databases
GeneID	4096524.
GenomeReviews	Gene locus Bcen_6170 in contig CP000380_GR.
KEGG	bcn:Bcen_6170.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0229.
HOGENOM	HBG715255.
OMA	VEVRCNH.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
TIGRFAMs	TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_BURCA

Accession

Primary (citable) accession number: Q1BH71

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 11, 2006
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)