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Q1BFR7 (Q1BFR7_MYCSS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase HAMAP MF_00012
Short name=DAD HAMAP MF_00012
EC=4.2.1.9 HAMAP MF_00012
Gene names
Name:ilvD HAMAP MF_00012
Ordered Locus Names:Mmcs_0146
OrganismMycobacterium sp. (strain MCS) [Complete proteome] [HAMAP]
Taxonomic identifier164756 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length580 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster By similarity. HAMAP MF_00012

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family. HAMAP MF_00012

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding1421Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012
Metal binding2191Iron-sulfur (4Fe-4S) By similarity HAMAP MF_00012

Sequences

Sequence LengthMass (Da)Tools
Q1BFR7 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: B639D19528025E5E

FASTA58060,522
        10         20         30         40         50         60 
MPSGSSGTPA DALRASDSSP DIKPRSRDVT DGLEKTAARG MLRAVGMGDD DWVKPQIGVG 

        70         80         90        100        110        120 
SSWNEITPCN MSLQRLAQSV KGGVHSAGGF PLEFGTISVS DGISMGHEGM HFSLVSREVI 

       130        140        150        160        170        180 
ADSVETVVQA ERLDGTVLLA GCDKSIPGML MAAARLDLAS VFLYNGSIMP GVAKLTDGSE 

       190        200        210        220        230        240 
REVTIIDAFE AVGACARGLM SREDVDIIER AICPGEGACG GMYTANTMAS AAEALGMSLP 

       250        260        270        280        290        300 
GSASPVAIDK RRDEYARKSG EAVVEMLRRG ITARDILTKE AFENAIAVVM AFGGSTNAVL 

       310        320        330        340        350        360 
HLLAIAWEAN VKLTLEDFTR VGQKVPHLAD VKPFGRHVMK HVDEIGGVPV VMKALLDAGL 

       370        380        390        400        410        420 
LHGDCLTITG ETMAENLAHI EPPDPDGKVL RAMNNPIHPT GGITILHGSL APEGAVVKSA 

       430        440        450        460        470        480 
GFDSDVFEGT ARVFERERAA LDALEDGTIT HGDVVVIRYE GPKGGPGMRE MLAITGAIKG 

       490        500        510        520        530        540 
AGLGKDVLLM TDGRFSGGTT GLCVGHIAPE AVDGGPIAFV RDGDRIRLDV AKGTLDLLVD 

       550        560        570        580 
EAEFESRKAG FEPLPPVYTT GVLAKYTKLV GSAAVGAVCG

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References

[1]"Complete sequence of chromosome of Mycobacterium sp. MCS."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Miller C.D., Hughes J.E., Anderson A.J., Sims R.C., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MCS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000384 Genomic DNA. Translation: ABG06267.1.
RefSeqYP_637323.1. NC_008146.1.

3D structure databases

ProteinModelPortalQ1BFR7.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1BFR7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000061121; EBMYCP00000059288; EBMYCG00000061116.
GeneID4108992.
GenomeReviewsGene locus Mmcs_0146 in contig CP000384_GR.
KEGGmmc:Mmcs_0146.
PATRIC18110373. VBIMycSp106721_0150.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0129.
GeneTreeEBGT00050000016366.
HOGENOMHBG671001.
OMANMPGAMI.
ProtClustDBPRK00911.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1BFR7_MYCSS
AccessionPrimary (citable) accession number: Q1BFR7
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: December 14, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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