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Protein

Acetate kinase

Gene

ackA

Organism
Mycobacterium sp. (strain MCS)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. no protein annotated in this organism
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9MagnesiumUniRule annotation1
Binding sitei16ATPUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Active sitei147Proton donor/acceptorUniRule annotation1
Sitei179Transition state stabilizerUniRule annotation1
Sitei240Transition state stabilizerUniRule annotation1
Metal bindingi387MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi207 – 211ATPUniRule annotation5
Nucleotide bindingi281 – 283ATPUniRule annotation3
Nucleotide bindingi333 – 337ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Mmcs_0538
OrganismiMycobacterium sp. (strain MCS)
Taxonomic identifieri164756 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000022441 – 399Acetate kinaseAdd BLAST399

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ1BEM5.
SMRiQ1BEM5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000288399.
KOiK00925.
OMAiWKALTGT.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1BEM5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRTVLVLNS GSSSLKFQLL EPDSGASLAD GIVERIGEDS SSASLVCGER
60 70 80 90 100
EVTHSERVPD HEAALRTAYG LFDEAGAELG SVGLVAVGHR VVHGGPDLYQ
110 120 130 140 150
PTLIDDALVD TLESLAPLAP LHNPPAVLGI RGARKAFPDL PHVAVFDTAY
160 170 180 190 200
FHDLPVAAAT YAIDRDLSEQ WHIRRYGFHG TSHQYVSEQA ALFLDVPLSS
210 220 230 240 250
LSQIVLHLGN GASASAILGG RPIDTSMGLT PMEGLVMGTR SGDVDPGVLV
260 270 280 290 300
YLWRTAGMSV DEIETMLNKR SGVRGLGGEI DFRVLHQRIE SGDESDRENA
310 320 330 340 350
QLAYDVYIHR LRKYIGAYLA LLGSTDVIVF TAGVGENDAA VRRDALSGMG
360 370 380 390
RLGIELDEHL NESPSHTARR ISAETSPTTV LVIPTNEELA IARACVEVI
Length:399
Mass (Da):42,760
Last modified:July 11, 2006 - v1
Checksum:iB141C932E604B165
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA. Translation: ABG06659.1.
RefSeqiWP_011557964.1. NC_008146.1.

Genome annotation databases

EnsemblBacteriaiABG06659; ABG06659; Mmcs_0538.
GeneIDi32419022.
KEGGimmc:Mmcs_0538.

Similar proteinsi

Entry informationi

Entry nameiACKA_MYCSS
AccessioniPrimary (citable) accession number: Q1BEM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: July 5, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families