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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Mycobacterium sp. (strain MCS)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
Ordered Locus Names:Mmcs_1926
OrganismiMycobacterium sp. (strain MCS)
Taxonomic identifieri164756 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_50001241511 – 2182-phospho-L-lactate guanylyltransferaseAdd BLAST218

Structurei

3D structure databases

ProteinModelPortaliQ1BAP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223639
KOiK14941
OMAiAMLVDTI

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

Q1BAP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGTTSNGAA PSGAGVAVVI AVKRLADAKT RLAPIFAPHD RETVVLAMLV
60 70 80 90 100
DTVAAAAAVA AVTVVTPDPA AAEAARALGA QVLDDPTPAG HPDPLNNALR
110 120 130 140 150
AAEAAVRATV PNVVALQGDL PALQAQELSE AIAAARTRPR SFVGDRHGTG
160 170 180 190 200
TSALFAFGVP LDPRFGPDSA ERHRRSGAVE LTGSWPGLRY DIDTPDDLLA
210
ARRLGVGTQT ARAVGAER
Length:218
Mass (Da):22,267
Last modified:July 11, 2006 - v1
Checksum:i3286A18FFD27F9CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA Translation: ABG08035.1
RefSeqiWP_011559326.1, NC_008146.1

Genome annotation databases

EnsemblBacteriaiABG08035; ABG08035; Mmcs_1926
GeneIDi32420276
KEGGimmc:Mmcs_1926

Similar proteinsi

Entry informationi

Entry nameiCOFC_MYCSS
AccessioniPrimary (citable) accession number: Q1BAP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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