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Protein

Ribonuclease HII

Gene

rnhB

Organism
Mycobacterium sp. (strain MCS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mn2+UniRule annotation, Mg2+UniRule annotationNote: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Divalent metal cationUniRule annotation
Metal bindingi37 – 371Divalent metal cationUniRule annotation
Metal bindingi130 – 1301Divalent metal cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciMSP164756:GHQ8-1986-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HIIUniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase HIIUniRule annotation
Gene namesi
Name:rnhBUniRule annotation
Ordered Locus Names:Mmcs_1972
OrganismiMycobacterium sp. (strain MCS)
Taxonomic identifieri164756 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239Ribonuclease HIIPRO_1000031167Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1BAK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase HII family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000100288.
KOiK03470.
OMAiGFASHKG.
OrthoDBiEOG6BKJC8.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1BAK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASWPPRTV IRKASGLRTL ESALYRNGLG PVAGVDEVGR GACAGPLVVA
60 70 80 90 100
ACVLGPNRLE SLAALDDSKK LGEKERERLF PVIRRYALAY HVVFIPSEEV
110 120 130 140 150
DRRGVHVANI EGMRRAVAGL SVRPGYVLSD GFRVPGLPMP SLPVVGGDAA
160 170 180 190 200
AACIAAASVL AKVSRDRLMV AMEREHPGYG FAEHKGYSTP AHTAALAELG
210 220 230
PCAQHRYSFI NVRRLVTAGT PQISGGLTDA EPGQCCELG
Length:239
Mass (Da):25,290
Last modified:July 11, 2006 - v1
Checksum:iB4D1F7FB8FD21694
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA. Translation: ABG08081.1.
RefSeqiWP_011559371.1. NC_008146.1.

Genome annotation databases

EnsemblBacteriaiABG08081; ABG08081; Mmcs_1972.
KEGGimmc:Mmcs_1972.
PATRICi18114129. VBIMycSp106721_2018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA. Translation: ABG08081.1.
RefSeqiWP_011559371.1. NC_008146.1.

3D structure databases

ProteinModelPortaliQ1BAK3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG08081; ABG08081; Mmcs_1972.
KEGGimmc:Mmcs_1972.
PATRICi18114129. VBIMycSp106721_2018.

Phylogenomic databases

HOGENOMiHOG000100288.
KOiK03470.
OMAiGFASHKG.
OrthoDBiEOG6BKJC8.

Enzyme and pathway databases

BioCyciMSP164756:GHQ8-1986-MONOMER.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00052_B. RNase_HII_B.
InterProiIPR022898. RNase_HII.
IPR001352. RNase_HII/HIII.
IPR024567. RNase_HII/HIII_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10954. PTHR10954. 1 hit.
PfamiPF01351. RNase_HII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS.

Entry informationi

Entry nameiRNH2_MYCSS
AccessioniPrimary (citable) accession number: Q1BAK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: December 9, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.