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Q1BA76

- PNP_MYCSS

UniProt

Q1BA76 - PNP_MYCSS

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Mycobacterium sp. (strain MCS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi522 – 5221MagnesiumUniRule annotation
Metal bindingi528 – 5281MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciMSP164756:GHQ8-2114-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Mmcs_2100
OrganismiMycobacterium sp. (strain MCS)
Taxonomic identifieri164756 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000001972: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Polyribonucleotide nucleotidyltransferasePRO_0000329723Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi164756.Mmcs_2100.

Structurei

3D structure databases

ProteinModelPortaliQ1BA76.
SMRiQ1BA76. Positions 13-722.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini588 – 64760KHUniRule annotationAdd
BLAST
Domaini659 – 72870S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1BA76-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVVEIEDGV YESTAVIDNG SFGTRTIRFE TGRLAQQAAG AVVAYLDDET
60 70 80 90 100
MLLSATSASK SPKDHFDFFP LTIDVEERMY AAGRIPGSFF RREGRPSTDA
110 120 130 140 150
ILTCRLIDRP LRPTFVSGLR NEIQVVVTVM SLDPKDLYDV VAINAASAST
160 170 180 190 200
QIAGLPFSGP VGGVRVALID GTWVAFPTVE QLERAVFDMV VAGRKTADDV
210 220 230 240 250
AIMMVEAEAT DKVVELVAGG AQAPTEAVVA EGLEAAKPFI KVLCEAQQEL
260 270 280 290 300
AGRAAKPTAD YPLFPEYGED VYYAVASVAT DALSEALTIA GKEERNNRTD
310 320 330 340 350
EIKVEVLGRL ADQFAGREKE IGGAFRSLTK KLVRQRILTD HFRIDGRGVT
360 370 380 390 400
DIRALSAEVA IVPRAHGSAL FERGETQILG VTTLDMVKMA QQIDSLGPET
410 420 430 440 450
SKRYMHHYNF PPYSTGETGR VGSPKRREIG HGALAERALM PVLPSVEEFP
460 470 480 490 500
YAIRQVSEAL SSNGSTSMGS VCASTLSLLN AGVPLKAPVA GIAMGLVSDD
510 520 530 540 550
VEVDGKTERR FVTLTDILGA EDAFGDMDFK CAGTKDFVTA LQLDTKLDGI
560 570 580 590 600
PSQVLAGALA QAKDARITIL EVMAEAIDAP DEMSPYAPRI TTIKVPVDKI
610 620 630 640 650
GEVIGPKGKM INSITEETGA SISIEDDGTV FVGASNGEAA QAAIDKINAI
660 670 680 690 700
ANPQLPKIGE RFLGTVVKTT DFGAFVSLLP GRDGLVHISK LGRGKRIAKV
710 720 730 740 750
EDVAKVGDKL RVEIADIDNR GKISLVLVAE EEAAEASDNG SATPSDKAPA

TADATTAGN
Length:759
Mass (Da):80,676
Last modified:July 11, 2006 - v1
Checksum:i1DAE4E88C36EF12E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000384 Genomic DNA. Translation: ABG08208.1.
RefSeqiYP_639264.1. NC_008146.1.

Genome annotation databases

EnsemblBacteriaiABG08208; ABG08208; Mmcs_2100.
GeneIDi4110933.
KEGGimmc:Mmcs_2100.
PATRICi18114392. VBIMycSp106721_2149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000384 Genomic DNA. Translation: ABG08208.1 .
RefSeqi YP_639264.1. NC_008146.1.

3D structure databases

ProteinModelPortali Q1BA76.
SMRi Q1BA76. Positions 13-722.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 164756.Mmcs_2100.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG08208 ; ABG08208 ; Mmcs_2100 .
GeneIDi 4110933.
KEGGi mmc:Mmcs_2100.
PATRICi 18114392. VBIMycSp106721_2149.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci MSP164756:GHQ8-2114-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS.

Entry informationi

Entry nameiPNP_MYCSS
AccessioniPrimary (citable) accession number: Q1BA76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 11, 2006
Last modified: October 29, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3