Q1BA69 (DAPB_MYCSS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Mmcs_2107

Organism

Mycobacterium sp. (strain MCS) [Complete proteome] [HAMAP]

Taxonomic identifier

164756 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000008600

Sequences

	Sequence		Length	Mass (Da)
	Q1BA69 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 37D81EC2C5CD6419	FASTA	245	25,838
	10 20 30 40 50 60 MRVGVLGAKG KVGATMVQAV EAADDLTFTT GVDAGDPLSA LVDTRTDVVI DFTHPSVVMD 70 80 90 100 110 120 NLKFLIDNGI HAVVGTTGFT DERISQVQDW LADKPESAVL IAPNFAIGAV LSMHFAQQAA 130 140 150 160 170 180 RFFESVEVIE LHHPHKADAP SGTAARTAKL IAAARKDMPP NPDATSTGLE GARGADVDGI 190 200 210 220 230 240 PVHSIRLAGL VAHQEVLFGT QGETLTIRHD SLDRTSFVPG VLLAVRKVSE RPGLTVGIEP LLDLT

References

[1]

"Complete sequence of chromosome of Mycobacterium sp. MCS." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Miller C.D., Hughes J.E., Anderson A.J., Sims R.C., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MCS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000384 Genomic DNA. Translation: ABG08215.1.
RefSeq	YP_639271.1. NC_008146.1.
3D structure databases
ProteinModelPortal	Q1BA69.
SMR	Q1BA69. Positions 1-244.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1BA69.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000061192; EBMYCP00000059359; EBMYCG00000061187.
GeneID	4110940.
GenomeReviews	Gene locus Mmcs_2107 in contig CP000384_GR.
KEGG	mmc:Mmcs_2107.
PATRIC	18114406. VBIMycSp106721_2156.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0289.
GeneTree	EBGT00050000017074.
HOGENOM	HBG594002.
OMA	DRASFMP.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	MSP164756:MMCS_2107-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_MYCSS

Accession

Primary (citable) accession number: Q1BA69

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program