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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium sp. (strain MCS)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei172 – 1721UniRule annotation
Active sitei604 – 6041UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciMSP164756:GHQ8-2426-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:Mmcs_2408Imported
OrganismiMycobacterium sp. (strain MCS)Imported
Taxonomic identifieri164756 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000001972: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi164756.Mmcs_2408.

Structurei

3D structure databases

ProteinModelPortaliQ1B9B8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1B9B8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRVRRTPIL ERMADLPEAL EPIGSVTRTE VGREASEPMR EDIRLLGAIL
60 70 80 90 100
GDTVREQNGE DVFDLVERAR VESFRVRRSE IDRAELAGLF DGIGVRAAIP
110 120 130 140 150
VIRAFTHFAL LANVAEDIHR ERRRAVHVAA GEPPQDSSLA ATYAKLDSAQ
160 170 180 190 200
LDSDEVSAAL SGALVSPVIT AHPTETRRRT VFDTQHRITE LMRLRAHGHE
210 220 230 240 250
TTDDGRDIEL ELRRHILTLW QTALIRLSRL KIQDEIETGL RYYRAAFFEV
260 270 280 290 300
IPRVNAEVRS ALQTRWPDAD LLAEPILRPG SWIGGDRDGN PNVTAEVVRQ
310 320 330 340 350
ATSRAAYTAF EHYFAELTGL EQELSMSARL VHVSDELAAL ADACHEAARA
360 370 380 390 400
DEPYRRALRV IHGRLTATAL EILDNQPEHE LDLGLERYAT PAELLADLDV
410 420 430 440 450
IDASLRGHGS AVLADDRLLR LREAVRVFGF HLSGLDMRQN SDVHEEVVAE
460 470 480 490 500
LLAWAGVHDD YASLPESDRI DLLVSELATR RPLTSQKAEL SELARKELDI
510 520 530 540 550
VRAGARAVRV FGPQAVPNYI ISMCESVSDM LEAAILLKEA GLLDVSDDEP
560 570 580 590 600
YAPVGIVPLF ETIDDLQRGS SILEAALDLP LYRGMVTARG DSQEVMLGYS
610 620 630 640 650
DSNKDGGYLA ANWALYRAEL DLVESSRKTG IRLRLFHGRG GTVGRGGGPS
660 670 680 690 700
YDAILAQPPG AVNGSLRITE QGEVIAAKYA EPRIAHRNLE TLVAATLEST
710 720 730 740 750
LLDVEGLGDE AGPAYEVLDD LAARAQRAYA ELVHETPGFV DYFKASTPVS
760 770 780 790 800
EIGALNIGSR PASRKPTTSI SDLRAIPWVL SWSQSRVMLP GWYGTGSAFE
810 820 830 840 850
QYIAEGAAES EDRLGVLQDL YRRWPFFRTV LSNMAQVLAK SDLGLAARYS
860 870 880 890 900
ELVEDEDLRR RVFDKIADEH ERTIRMHRLI TGQDDLLADN PALARSVFNR
910 920 930 940
FPYLEPLNHL QVELLRRYRS GEDDELVQRG ILLTMSGLAT ALRNSG
Length:946
Mass (Da):104,886
Last modified:July 11, 2006 - v1
Checksum:i73E65D55F5A78AA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA. Translation: ABG08516.1.
RefSeqiYP_639572.1. NC_008146.1.

Genome annotation databases

EnsemblBacteriaiABG08516; ABG08516; Mmcs_2408.
GeneIDi4111241.
KEGGimmc:Mmcs_2408.
PATRICi18115038. VBIMycSp106721_2468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA. Translation: ABG08516.1.
RefSeqiYP_639572.1. NC_008146.1.

3D structure databases

ProteinModelPortaliQ1B9B8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi164756.Mmcs_2408.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG08516; ABG08516; Mmcs_2408.
GeneIDi4111241.
KEGGimmc:Mmcs_2408.
PATRICi18115038. VBIMycSp106721_2468.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238647.
KOiK01595.
OMAiFTSNWEL.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciMSP164756:GHQ8-2426-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCSImported.

Entry informationi

Entry nameiQ1B9B8_MYCSS
AccessioniPrimary (citable) accession number: Q1B9B8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: February 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.