Q1B832 (GCSH_MYCSS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine cleavage system H protein

Gene names

Name:	gcvH
Ordered Locus Names:	Mmcs_2845

Organism

Mycobacterium sp. (strain MCS) [Complete proteome] [HAMAP]

Taxonomic identifier

164756 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein By similarity. HAMAP-Rule MF_00272
Cofactor	Binds 1 lipoyl cofactor covalently By similarity.
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvH family. Contains 1 lipoyl-binding domain.

Ontologies

Keywords
Domain	Lipoyl
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular_component	glycine cleavage complex Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 131	131	Glycine cleavage system H protein HAMAP-Rule MF_00272		PRO_0000302396
Amino acid modifications
	Modified residue	65	1	N6-lipoyllysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1B832 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: EF8B809296E26018	FASTA	131	13,957
	10 20 30 40 50 60 MSEIPAELYY TDEHEWVLRT GDDTLRVGIT DYAQAALGDV VFVQLPDVGA ELTSGESFGE 70 80 90 100 110 120 VESTKSVSDL YAPVSAKVLA VNGNLEASPD LVNSDPYGEG WLVDLQLDAD DMEAALGGLL 130 DADGYRGVVT E

References

[1]

"Complete sequence of chromosome of Mycobacterium sp. MCS." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Miller C.D., Hughes J.E., Anderson A.J., Sims R.C., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MCS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000384 Genomic DNA. Translation: ABG08952.1.
RefSeq	YP_640008.1. NC_008146.1.
3D structure databases
ProteinModelPortal	Q1B832.
ModBase	Search...
Protein-protein interaction databases
STRING	164756.Mmcs_2845.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABG08952; ABG08952; Mmcs_2845.
GeneID	4111677.
KEGG	mmc:Mmcs_2845.
PATRIC	18115947. VBIMycSp106721_2922.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0509.
HOGENOM	HOG000239392.
KO	K02437.
OMA	PEEAGWF.
ProtClustDB	PRK01202.
Enzyme and pathway databases
BioCyc	MSP164756:GHQ8-3131-MONOMER.
Family and domain databases
HAMAP	MF_00272. GcvH.
InterPro	IPR002930. GCV_H. IPR017453. GCV_H_sub. IPR011053. Single_hybrid_motif. [Graphical view]
PANTHER	PTHR11715. PTHR11715. 1 hit.
Pfam	PF01597. GCV_H. 1 hit. [Graphical view]
SUPFAM	SSF51230. Hybrid_motif. 1 hit.
TIGRFAMs	TIGR00527. gcvH. 1 hit.
PROSITE	PS00189. LIPOYL. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSH_MYCSS

Accession

Primary (citable) accession number: Q1B832

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 11, 2006
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program