Q1B7H6 (TRPC_MYCSS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	Mmcs_3051

Organism

Mycobacterium sp. (strain MCS) [Complete proteome] [HAMAP]

Taxonomic identifier

164756 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000018504

Sequences

	Sequence		Length	Mass (Da)
	Q1B7H6 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 90379122A939E483	FASTA	272	28,666
	10 20 30 40 50 60 MSSATVLDSI IEGVRADVAA REAVVSLTEI KERAQRAKPP LDVMAALREP GIGVIAEVKR 70 80 90 100 110 120 ASPSRGALAQ IGDPADLARA YQDGGARVIS VLTEQRRFNG SLDDLDAVRA AVSIPVLRKD 130 140 150 160 170 180 FIVRPYQIHE ARAHGADMLL LIVAALEQPV LESLLERTES LGMTALVEVH TEAEADRALQ 190 200 210 220 230 240 AGARVIGVNA RNLKTLEVDR DCFARIAPGL PSNVIRIAES GVRGPADLLA YAGAGADAVL 250 260 270 VGEGLVTSRD PRSAVADLVT AGTHPSCPKP SR

References

[1]

"Complete sequence of chromosome of Mycobacterium sp. MCS." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. , Miller C.D., Hughes J.E., Anderson A.J., Sims R.C., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MCS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000384 Genomic DNA. Translation: ABG09158.1.
RefSeq	YP_640214.1. NC_008146.1.
3D structure databases
ProteinModelPortal	Q1B7H6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1B7H6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000063094; EBMYCP00000061261; EBMYCG00000063089.
GeneID	4111883.
GenomeReviews	Gene locus Mmcs_3051 in contig CP000384_GR.
KEGG	mmc:Mmcs_3051.
PATRIC	18116369. VBIMycSp106721_3127.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0134.
GeneTree	EBGT00050000017090.
HOGENOM	HBG540956.
OMA	MRKDDVT.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	MSP164756:MMCS_3051-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_MYCSS

Accession

Primary (citable) accession number: Q1B7H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program