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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Mycobacterium sp. (strain MCS)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciMSP164756:GHQ8-3284-MONOMER.
UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:Mmcs_3256
OrganismiMycobacterium sp. (strain MCS)
Taxonomic identifieri164756 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferasePRO_0000315122Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ1B6X1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218323.
KOiK02563.
OMAiHQTKNAM.

Family and domain databases

HAMAPiMF_00033. MurG. 1 hit.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1B6X1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGTISVLLA GGGTAGHVEP AMAVADALAA LEPGVRITAL GTERGLETRL
60 70 80 90 100
VPERGYALEL ITPVPLPRKL SGDLARLPMR VRRAVRETRE ILDTVHADVV
110 120 130 140 150
IGFGGYVALP AYLAARRNRV PIVVHEANAS AGLANKVGAR FARRVLSAVA
160 170 180 190 200
DPGLGRVEVV GTPVRSSITE LDRAALRAEA RAHFGFADDA RVLLVFGGSQ
210 220 230 240 250
GARSLNNVVS GAAKALAAAG ISVLHAYGAK NTLELPDPAP GDPPYVAVPY
260 270 280 290 300
LSRMDLAYAA ADLAICRSGA MTVAEVTAVG LPAVYVPLPI GNGEQRLNAR
310 320 330 340 350
PVVETGGGLV VDDADLSPQF VADTVVPLLT DTGRLQTMTA GAALSGHRDA
360 370
ARHVAHVALD VAREAAGGRK GVR
Length:373
Mass (Da):38,517
Last modified:July 11, 2006 - v1
Checksum:i1D4B927E7D1FC853
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA. Translation: ABG09363.1.
RefSeqiWP_011560639.1. NC_008146.1.

Genome annotation databases

EnsemblBacteriaiABG09363; ABG09363; Mmcs_3256.
KEGGimmc:Mmcs_3256.
PATRICi18116791. VBIMycSp106721_3337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA. Translation: ABG09363.1.
RefSeqiWP_011560639.1. NC_008146.1.

3D structure databases

ProteinModelPortaliQ1B6X1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT28. Glycosyltransferase Family 28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG09363; ABG09363; Mmcs_3256.
KEGGimmc:Mmcs_3256.
PATRICi18116791. VBIMycSp106721_3337.

Phylogenomic databases

HOGENOMiHOG000218323.
KOiK02563.
OMAiHQTKNAM.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciMSP164756:GHQ8-3284-MONOMER.

Family and domain databases

HAMAPiMF_00033. MurG. 1 hit.
InterProiIPR006009. GlcNAc_MurG.
IPR007235. Glyco_trans_28_C.
IPR004276. GlycoTrans_28_N.
[Graphical view]
PfamiPF04101. Glyco_tran_28_C. 1 hit.
PF03033. Glyco_transf_28. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01133. murG. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURG_MYCSS
AccessioniPrimary (citable) accession number: Q1B6X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 11, 2006
Last modified: September 7, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.