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Q1B630 (Q1B630_MYCSS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate 5-kinase HAMAP MF_00456
EC=2.7.2.11 HAMAP MF_00456
Alternative name(s):
Gamma-glutamyl kinase HAMAP MF_00456
Gene names
Name:proB HAMAP MF_00456
Ordered Locus Names:Mmcs_3547
OrganismMycobacterium sp. (strain MCS) [Complete proteome] [HAMAP]
Taxonomic identifier164756 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline By similarity. HAMAP MF_00456 SAAS SAAS011529

Catalytic activity

ATP + L-glutamate = ADP + L-glutamate 5-phosphate. HAMAP MF_00456 SAAS SAAS011529

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2. HAMAP MF_00456 SAAS SAAS011529

Subcellular location

Cytoplasm By similarity SAAS SAAS011529 HAMAP MF_00456.

Sequence similarities

Belongs to the glutamate 5-kinase family. HAMAP MF_00456

Contains 1 PUA domain. HAMAP MF_00456 SAAS SAAS011529

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain289 – 36779PUA By similarity HAMAP MF_00456

Sequences

Sequence LengthMass (Da)Tools
Q1B630 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 5B5153EEAB216635

FASTA37739,290
        10         20         30         40         50         60 
MTEAATRPSV HREAVRTARS VVVKIGTTAL TTPTGVFDAN RLATLVEAIE KRMKAGSDVV 

        70         80         90        100        110        120 
IVSSGAIAAG IEPLRLSKRP TDLATKQAAA SVGQVALINS WNTAFARYER TVGQVLLTAH 

       130        140        150        160        170        180 
DISMRVQHTN AARTLDRLRA LHAVAIVNEN DTVATNEIRF GDNDRLSALV AHLVGADALV 

       190        200        210        220        230        240 
LLSDIDGLYD GDPRKAGPDN PARFIAEVNG ADDLDGVVAG RGSHLGTGGM ASKLSSALLA 

       250        260        270        280        290        300 
ADAGVPVLLA AAADAATALS DASVGTVFAP RAERMSARRF WVRYAAESTG ALTLDEGAVN 

       310        320        330        340        350        360 
AVVRQRRSLL PAGITGVSGR FYGGDVVELR APDATMVARG VVAYDATELA TMLGRSTSDL 

       370 
PADMRRPAVH ADDLVAV

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References

[1]"Complete sequence of chromosome of Mycobacterium sp. MCS."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Miller C.D., Hughes J.E., Anderson A.J., Sims R.C., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MCS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000384 Genomic DNA. Translation: ABG09654.1.
RefSeqYP_640710.1. NC_008146.1.

3D structure databases

ProteinModelPortalQ1B630.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1B630.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000063949; EBMYCP00000062116; EBMYCG00000063944.
GeneID4112379.
GenomeReviewsGene locus Mmcs_3547 in contig CP000384_GR.
KEGGmmc:Mmcs_3547.
PATRIC18117389. VBIMycSp106721_3634.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0263.
GeneTreeEBGT00050000017499.
HOGENOMHBG507643.
OMATFGDNDM.
ProtClustDBPRK05429.

Family and domain databases

HAMAPMF_00456. ProB.
[Tree]
InterProIPR001048. Asp/Glu/Uridylate_kinase.
IPR001057. Glu/AcGlu_kinase.
IPR011529. Glu_5kinase.
IPR005715. Glu_5kinase/COase_Synthase.
IPR019797. Glutamate_5-kinase_CS.
IPR002478. PUA.
IPR015947. PUA-like_domain.
[Graphical view]
Gene3DG3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KOK00931.
PfamPF00696. AA_kinase. 1 hit.
PF01472. PUA. 1 hit.
[Graphical view]
PIRSFPIRSF000729. GK. 1 hit.
PRINTSPR00474. GLU5KINASE.
SMARTSM00359. PUA. 1 hit.
[Graphical view]
SUPFAMSSF53633. Aa_kinase. 1 hit.
SSF88697. PUA-like. 1 hit.
TIGRFAMsTIGR01027. ProB. 1 hit.
PROSITEPS00902. GLUTAMATE_5_KINASE. 1 hit.
PS50890. PUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1B630_MYCSS
AccessionPrimary (citable) accession number: Q1B630
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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