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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Mycobacterium sp. (strain MCS)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciMSP164756:GHQ8-4149-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:Mmcs_4107
OrganismiMycobacterium sp. (strain MCS)
Taxonomic identifieri164756 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Exodeoxyribonuclease 7 large subunitPRO_0000303803Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229264.
KOiK03601.
OMAiPRKGHIF.
OrthoDBiEOG64R65J.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1B4H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTPADDQGK SPENPWPVRA VATRVAKYID RLGMVWIEGQ LTELKIRQTT
60 70 80 90 100
AWMVLRDPAA DMSLSVSCPR DLVANAPVPL SEGTQVIVLG KPQFYTRNGS
110 120 130 140 150
FSLRISEIRA VGIGELLARI DRLRRLLDAE GLFDPRLKRP IPFLPGTIGL
160 170 180 190 200
ITGRASHAER DVMTVAANRW PAVRFAVRNT IVQGPNAVPQ IVGALRELDR
210 220 230 240 250
DPGVDVIVLA RGGGSVEDLL PFSDETLCRE IASCTTPVVS AVGHEPDNPL
260 270 280 290 300
CDLVADLRAA TPTDAAKRVV PDAAAEQAFV TDLRRRSARA LRQWVHREQH
310 320 330 340 350
HLDQLRSRPV LARPLQAIDA RADEVHRAVA AARRDVRRMV TVESERVGHL
360 370 380 390 400
SARLTTLGPA ATLARGYAVV QTMPDTNVLR TTADAPAGTH LRIRVADGAI
410
TAVSEGTDEA H
Length:411
Mass (Da):44,739
Last modified:July 11, 2006 - v1
Checksum:iB8F0BDE201BAD169
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA. Translation: ABG10212.1.
RefSeqiWP_011561485.1. NC_008146.1.

Genome annotation databases

EnsemblBacteriaiABG10212; ABG10212; Mmcs_4107.
KEGGimmc:Mmcs_4107.
PATRICi18118555. VBIMycSp106721_4207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000384 Genomic DNA. Translation: ABG10212.1.
RefSeqiWP_011561485.1. NC_008146.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG10212; ABG10212; Mmcs_4107.
KEGGimmc:Mmcs_4107.
PATRICi18118555. VBIMycSp106721_4207.

Phylogenomic databases

HOGENOMiHOG000229264.
KOiK03601.
OMAiPRKGHIF.
OrthoDBiEOG64R65J.

Enzyme and pathway databases

BioCyciMSP164756:GHQ8-4149-MONOMER.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 2 hits.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS.

Entry informationi

Entry nameiEX7L_MYCSS
AccessioniPrimary (citable) accession number: Q1B4H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 11, 2006
Last modified: November 11, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.