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Q1B2H1 (Q1B2H1_MYCSS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123
Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123
Gene names
Name:acsA HAMAP MF_01123
Ordered Locus Names:Mmcs_4809
OrganismMycobacterium sp. (strain MCS) [Complete proteome] [HAMAP]
Taxonomic identifier164756 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length660 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site5291 By similarity HAMAP MF_01123

Amino acid modifications

Modified residue6231N6-acetyllysine By similarity HAMAP MF_01123

Sequences

Sequence LengthMass (Da)Tools
Q1B2H1 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 1DBD8161A1A8CEA7

FASTA66072,445
        10         20         30         40         50         60 
MTTLTPMSDV HTEVPSSYPP PAEFAEQANA KAEMYREAEE DRLAFWAKQA ERLSWDTPFT 

        70         80         90        100        110        120 
EVLDWSDAPF AKWFVGGKIN VAYNCVDRHV EAGNGDRVAI HWEGEPVGDS RSLTYAELKD 

       130        140        150        160        170        180 
EVCKAANALT DLGLTAGDRA AIYMPMVPEA IVAMLACARL GVLHSVVFAG FSASALKARI 

       190        200        210        220        230        240 
EDAEAKLVIT TDGQYRRGKA ASLKDAVDEA VDGQPSIEHV LVVRRTGIDV KWTDGRDLWW 

       250        260        270        280        290        300 
HETVDGASTE HTPEAFDSEH PLFLLYTSGT TGKPKGIVHT TGGYLVQSSY THHNVFDVKP 

       310        320        330        340        350        360 
DTDVYWCTAD IGWVTGHTYI TYGPLSNGVT QVVYEGTPTS PSEHRHFEVI EKYGVTIYYT 

       370        380        390        400        410        420 
APTLVRTFMK LGRAVPDAHD LSSLRLLGSV GEPINPEAWR WYRNVFGDNN IPVVDTWWQT 

       430        440        450        460        470        480 
ETGAIMISPL PGVTAAKPGS AMTPLPGISA KIVDDDGNQL PPGSDHGEQA NGYLVLDQPW 

       490        500        510        520        530        540 
PAMLRGIWGD PQRFKETYWS RFAEQGWYFA GDGARYDADG NIWVLGRIDD VMNISGHRIS 

       550        560        570        580        590        600 
TAEVESALVG HSHVAEAAVV GATDDHTGQA ICAFVILESS AADKPHEHMV EELRAEVAKE 

       610        620        630        640        650        660 
ISPIARPREI HVVPELPKTR SGKIMRRLLR DVAEGRELGD TSTLVDPGVF EAIRASKAEV

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References

[1]"Complete sequence of chromosome of Mycobacterium sp. MCS."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E. expand/collapse author list , Miller C.D., Hughes J.E., Anderson A.J., Sims R.C., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MCS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000384 Genomic DNA. Translation: ABG10913.1.
RefSeqYP_641969.1. NC_008146.1.

3D structure databases

ProteinModelPortalQ1B2H1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1B2H1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000062114; EBMYCP00000060281; EBMYCG00000062109.
GeneID4113638.
GenomeReviewsGene locus Mmcs_4809 in contig CP000384_GR.
KEGGmmc:Mmcs_4809.
PATRIC18120016. VBIMycSp106721_4927.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0365.
GeneTreeEBGT00050000015141.
HOGENOMHBG547964.
OMAVISVSGH.
ProtClustDBPRK00174.

Family and domain databases

HAMAPMF_01123. Ac_CoA_synth.
[Tree]
InterProIPR011904. Ac_CoA_lig.
IPR024597. Acyl-CoA_synth_DUF3448.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
KOK01895.
PANTHERPTHR24095:SF42. PTHR24095:SF42. 1 hit.
PfamPF00501. AMP-binding. 1 hit.
PF11930. DUF3448. 1 hit.
[Graphical view]
TIGRFAMsTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ1B2H1_MYCSS
AccessionPrimary (citable) accession number: Q1B2H1
Entry history
Integrated into UniProtKB/TrEMBL: July 11, 2006
Last sequence update: July 11, 2006
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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