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Q1B0U5

- SYL_MYCSS

UniProt

Q1B0U5 - SYL_MYCSS

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Protein

Leucine--tRNA ligase

Gene
leuS, Mmcs_5389
Organism
Mycobacterium sp. (strain MCS)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei725 – 7251ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMSP164756:GHQ8-5449-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Mmcs_5389
OrganismiMycobacterium sp. (strain MCS)
Taxonomic identifieri164756 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000001972: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Leucine--tRNA ligaseUniRule annotationPRO_0000334778Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi164756.Mmcs_5389.

Structurei

3D structure databases

ProteinModelPortaliQ1B0U5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi72 – 8312"HIGH" regionUniRule annotationAdd
BLAST
Motifi722 – 7265"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1B0U5-1 [UniParc]FASTAAdd to Basket

« Hide

MTETPTAQPD RAADADTPQH RYTAELAGQI EGAWQQTWAV EGTFNVPNPV    50
GELAPPDGTV PADKMFVQDM FPYPSGEGLH VGHPLGYIAT DVYARYYRMT 100
GRNVLHALGF DAFGLPAEQY AVQTGTHPRT RTEANIVNFR RQLGRLGLGH 150
DTRRSFSTTD VDFYTWTQWI FLQIYNAWFD RDANRARPIA ELIGEFESGV 200
RTLDDGRPWS ELSAGERADV VDSYRLVYRA DSMVNWCPGL GTVLANEEVT 250
ADGRSDRGNF PVFRKRLRQW MMRITAYSDR LLEDLEVLDW PDKVKTMQRN 300
WIGRSTGASV QFGTDAGDIE VFTTRPDTLF GATYLVLAPE HPLVEQLAAE 350
QWPDDVDGRW TFGATTPREA VAAYRASIAA KSDLERQENK TKTGAFLGAY 400
ATNPANGQQV PIFIADYVLI GYGTGAIMAV PGHDQRDWEF AHEFGLPVVE 450
VISGGDISEA AYAGDGLLVN SDYLDGLDVA AAKAAITDRL VADGRGRARV 500
EYKLRDWLFA RQRYWGEPFP IVYDSDGRPH PLPESALPVE LPDVPDYSPV 550
LFDPDDADSE PNPPLNKATD WVHVELDLGD GLQTYTRDTN VMPQWAGSSW 600
YELRYTDPLN KEALCAKENE AYWMGPQPAE HGPDDPGGVD LYVGGVEHAV 650
LHLLYSRFWH KVLYDLGHVS SREPYRRLVN QGYIQAFAYT DSRGSYVPAA 700
EVVERDGKFW FEGAEVFQEF GKIGKSLKNS VSPDEICDNY GADTLRVYEM 750
SMGPLEASRP WATKDVVGAH RFLQRVWRLV VDEQSGAVRV ANHEALDTDT 800
LRALHRTVAG VSEDYAALRN NTAAAKLIEY TNHLTKEGVT ARAAIEPLVL 850
MVAPLAPHLA EELWRRLGHD TSLAHGPFPV ADPQYLVTDT VEYPVQVNGK 900
VRSRITVDAD AGKDTLEAAA LADEKVQAFL NGATPKKVIV VPGRLVNLVV 950
Length:950
Mass (Da):105,595
Last modified:May 20, 2008 - v2
Checksum:iF3C2F0E3A9616CC6
GO

Sequence cautioni

The sequence ABG11489.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000384 Genomic DNA. Translation: ABG11489.1. Different initiation.
RefSeqiYP_642545.1. NC_008146.1.

Genome annotation databases

EnsemblBacteriaiABG11489; ABG11489; Mmcs_5389.
GeneIDi4114215.
KEGGimmc:Mmcs_5389.
PATRICi18121210. VBIMycSp106721_5518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000384 Genomic DNA. Translation: ABG11489.1 . Different initiation.
RefSeqi YP_642545.1. NC_008146.1.

3D structure databases

ProteinModelPortali Q1B0U5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 164756.Mmcs_5389.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG11489 ; ABG11489 ; Mmcs_5389 .
GeneIDi 4114215.
KEGGi mmc:Mmcs_5389.
PATRICi 18121210. VBIMycSp106721_5518.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci MSP164756:GHQ8-5449-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MCS.

Entry informationi

Entry nameiSYL_MYCSS
AccessioniPrimary (citable) accession number: Q1B0U5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 14, 2014
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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