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Q1B0U5

- SYL_MYCSS

UniProt

Q1B0U5 - SYL_MYCSS

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Mycobacterium sp. (strain MCS)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei725 – 7251ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMSP164756:GHQ8-5449-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Mmcs_5389
    OrganismiMycobacterium sp. (strain MCS)
    Taxonomic identifieri164756 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
    ProteomesiUP000001972: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 950950Leucine--tRNA ligasePRO_0000334778Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi164756.Mmcs_5389.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1B0U5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi72 – 8312"HIGH" regionAdd
    BLAST
    Motifi722 – 7265"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1B0U5-1 [UniParc]FASTAAdd to Basket

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    MTETPTAQPD RAADADTPQH RYTAELAGQI EGAWQQTWAV EGTFNVPNPV    50
    GELAPPDGTV PADKMFVQDM FPYPSGEGLH VGHPLGYIAT DVYARYYRMT 100
    GRNVLHALGF DAFGLPAEQY AVQTGTHPRT RTEANIVNFR RQLGRLGLGH 150
    DTRRSFSTTD VDFYTWTQWI FLQIYNAWFD RDANRARPIA ELIGEFESGV 200
    RTLDDGRPWS ELSAGERADV VDSYRLVYRA DSMVNWCPGL GTVLANEEVT 250
    ADGRSDRGNF PVFRKRLRQW MMRITAYSDR LLEDLEVLDW PDKVKTMQRN 300
    WIGRSTGASV QFGTDAGDIE VFTTRPDTLF GATYLVLAPE HPLVEQLAAE 350
    QWPDDVDGRW TFGATTPREA VAAYRASIAA KSDLERQENK TKTGAFLGAY 400
    ATNPANGQQV PIFIADYVLI GYGTGAIMAV PGHDQRDWEF AHEFGLPVVE 450
    VISGGDISEA AYAGDGLLVN SDYLDGLDVA AAKAAITDRL VADGRGRARV 500
    EYKLRDWLFA RQRYWGEPFP IVYDSDGRPH PLPESALPVE LPDVPDYSPV 550
    LFDPDDADSE PNPPLNKATD WVHVELDLGD GLQTYTRDTN VMPQWAGSSW 600
    YELRYTDPLN KEALCAKENE AYWMGPQPAE HGPDDPGGVD LYVGGVEHAV 650
    LHLLYSRFWH KVLYDLGHVS SREPYRRLVN QGYIQAFAYT DSRGSYVPAA 700
    EVVERDGKFW FEGAEVFQEF GKIGKSLKNS VSPDEICDNY GADTLRVYEM 750
    SMGPLEASRP WATKDVVGAH RFLQRVWRLV VDEQSGAVRV ANHEALDTDT 800
    LRALHRTVAG VSEDYAALRN NTAAAKLIEY TNHLTKEGVT ARAAIEPLVL 850
    MVAPLAPHLA EELWRRLGHD TSLAHGPFPV ADPQYLVTDT VEYPVQVNGK 900
    VRSRITVDAD AGKDTLEAAA LADEKVQAFL NGATPKKVIV VPGRLVNLVV 950
    Length:950
    Mass (Da):105,595
    Last modified:May 20, 2008 - v2
    Checksum:iF3C2F0E3A9616CC6
    GO

    Sequence cautioni

    The sequence ABG11489.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000384 Genomic DNA. Translation: ABG11489.1. Different initiation.
    RefSeqiYP_642545.1. NC_008146.1.

    Genome annotation databases

    EnsemblBacteriaiABG11489; ABG11489; Mmcs_5389.
    GeneIDi4114215.
    KEGGimmc:Mmcs_5389.
    PATRICi18121210. VBIMycSp106721_5518.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000384 Genomic DNA. Translation: ABG11489.1 . Different initiation.
    RefSeqi YP_642545.1. NC_008146.1.

    3D structure databases

    ProteinModelPortali Q1B0U5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 164756.Mmcs_5389.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG11489 ; ABG11489 ; Mmcs_5389 .
    GeneIDi 4114215.
    KEGGi mmc:Mmcs_5389.
    PATRICi 18121210. VBIMycSp106721_5518.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci MSP164756:GHQ8-5449-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MCS.

    Entry informationi

    Entry nameiSYL_MYCSS
    AccessioniPrimary (citable) accession number: Q1B0U5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 69 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3