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Q1AXZ4 (FTHS1_RUBXD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase 1

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase 1
Short name=FHS 1
Short name=FTHFS 1
Gene names
Name:fhs1
Ordered Locus Names:Rxyl_0766
OrganismRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]
Taxonomic identifier266117 [NCBI]
Taxonomic lineageBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter

Protein attributes

Sequence length576 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 576576Formate--tetrahydrofolate ligase 1 HAMAP-Rule MF_01543
PRO_0000293054

Regions

Nucleotide binding69 – 768ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1AXZ4 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: 5DDF656C8B90F936

FASTA57661,554
        10         20         30         40         50         60 
MGEALSNLEI ARGAKLLPIE EVGRSMGLRE ERHLEPYGRH VAKVDLCAIE DLSERPKAKY 

        70         80         90        100        110        120 
ILVSAITPTP LGEGKTTTTV GLGQAFSHIG KRATIAIRQA SMGPAFGIKG GAAGGGYSQV 

       130        140        150        160        170        180 
VPMERLNLHL TGDLHAVTEA HNMLAAMIDN HLYHGNGLGI EPHSISWRRV MDVNDRSLRN 

       190        200        210        220        230        240 
IVIGLGARTD GVPRQSGFDI TAASEVMAIL ALASSLEDLR ERLGRIVIGH NREGNPVSAE 

       250        260        270        280        290        300 
DVRGAGAMAV ILKEAIKPNL MQTLEGTPAL VHAGPFGNIA TGNSSVVADL IGIRTADYLI 

       310        320        330        340        350        360 
TEAGFGADMG AERFFNIKCR ISGLEPDAAV VVATVRALKA HSGRYQIKAG APLPEELLEE 

       370        380        390        400        410        420 
NPQDVLAGAE NLKKQIENIK LHGVPAVVAI NAFPTDHPSE HKAIEEAAKE VGARCAVCRH 

       430        440        450        460        470        480 
FTEGGKGAVE LARALEETIE ENERERRRGG GGSFRFLYPL EMPLKQKIET IAREVYGAEG 

       490        500        510        520        530        540 
VEYDAEALRA LEGFERAGFG RLPVCLAKTH LSLSSDPALK GAPRGWKLSV REVRASVGAG 

       550        560        570 
FIYPICGQMR TMPGLSAHPA AERIDLDGEG NVVGLF 

« Hide

References

[1]"Complete sequence of Rubrobacter xylanophilus DSM 9941."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 9941 / NBRC 16129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000386 Genomic DNA. Translation: ABG03734.1.
RefSeqYP_643546.1. NC_008148.1.

3D structure databases

ProteinModelPortalQ1AXZ4.
SMRQ1AXZ4. Positions 7-574.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266117.Rxyl_0766.

Proteomic databases

PRIDEQ1AXZ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG03734; ABG03734; Rxyl_0766.
GeneID4116902.
KEGGrxy:Rxyl_0766.
PATRIC23368336. VBIRubXyl52678_0781.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycRXYL266117:GH8O-774-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS1_RUBXD
AccessionPrimary (citable) accession number: Q1AXZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways