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Q1AXZ4

- FTHS1_RUBXD

UniProt

Q1AXZ4 - FTHS1_RUBXD

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Protein

Formate--tetrahydrofolate ligase 1

Gene
fhs1, Rxyl_0766
Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 768ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-774-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 1 (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase 1
Short name:
FHS 1
Short name:
FTHFS 1
Gene namesi
Name:fhs1
Ordered Locus Names:Rxyl_0766
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Formate--tetrahydrofolate ligase 1UniRule annotationPRO_0000293054Add
BLAST

Proteomic databases

PRIDEiQ1AXZ4.

Interactioni

Protein-protein interaction databases

STRINGi266117.Rxyl_0766.

Structurei

3D structure databases

ProteinModelPortaliQ1AXZ4.
SMRiQ1AXZ4. Positions 7-574.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1AXZ4-1 [UniParc]FASTAAdd to Basket

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MGEALSNLEI ARGAKLLPIE EVGRSMGLRE ERHLEPYGRH VAKVDLCAIE    50
DLSERPKAKY ILVSAITPTP LGEGKTTTTV GLGQAFSHIG KRATIAIRQA 100
SMGPAFGIKG GAAGGGYSQV VPMERLNLHL TGDLHAVTEA HNMLAAMIDN 150
HLYHGNGLGI EPHSISWRRV MDVNDRSLRN IVIGLGARTD GVPRQSGFDI 200
TAASEVMAIL ALASSLEDLR ERLGRIVIGH NREGNPVSAE DVRGAGAMAV 250
ILKEAIKPNL MQTLEGTPAL VHAGPFGNIA TGNSSVVADL IGIRTADYLI 300
TEAGFGADMG AERFFNIKCR ISGLEPDAAV VVATVRALKA HSGRYQIKAG 350
APLPEELLEE NPQDVLAGAE NLKKQIENIK LHGVPAVVAI NAFPTDHPSE 400
HKAIEEAAKE VGARCAVCRH FTEGGKGAVE LARALEETIE ENERERRRGG 450
GGSFRFLYPL EMPLKQKIET IAREVYGAEG VEYDAEALRA LEGFERAGFG 500
RLPVCLAKTH LSLSSDPALK GAPRGWKLSV REVRASVGAG FIYPICGQMR 550
TMPGLSAHPA AERIDLDGEG NVVGLF 576
Length:576
Mass (Da):61,554
Last modified:July 11, 2006 - v1
Checksum:i5DDF656C8B90F936
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG03734.1.
RefSeqiWP_011563752.1. NC_008148.1.
YP_643546.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG03734; ABG03734; Rxyl_0766.
GeneIDi4116902.
KEGGirxy:Rxyl_0766.
PATRICi23368336. VBIRubXyl52678_0781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG03734.1 .
RefSeqi WP_011563752.1. NC_008148.1.
YP_643546.1. NC_008148.1.

3D structure databases

ProteinModelPortali Q1AXZ4.
SMRi Q1AXZ4. Positions 7-574.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266117.Rxyl_0766.

Proteomic databases

PRIDEi Q1AXZ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG03734 ; ABG03734 ; Rxyl_0766 .
GeneIDi 4116902.
KEGGi rxy:Rxyl_0766.
PATRICi 23368336. VBIRubXyl52678_0781.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RXYL266117:GH8O-774-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiFTHS1_RUBXD
AccessioniPrimary (citable) accession number: Q1AXZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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