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Protein

Formate--tetrahydrofolate ligase 1

Gene

fhs1

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway:itetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 768ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-774-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 1UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 1UniRule annotation
Short name:
FHS 1UniRule annotation
Short name:
FTHFS 1UniRule annotation
Gene namesi
Name:fhs1UniRule annotation
Ordered Locus Names:Rxyl_0766
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteriaRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Formate--tetrahydrofolate ligase 1PRO_0000293054Add
BLAST

Proteomic databases

PRIDEiQ1AXZ4.

Interactioni

Protein-protein interaction databases

STRINGi266117.Rxyl_0766.

Structurei

3D structure databases

ProteinModelPortaliQ1AXZ4.
SMRiQ1AXZ4. Positions 7-574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1AXZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEALSNLEI ARGAKLLPIE EVGRSMGLRE ERHLEPYGRH VAKVDLCAIE
60 70 80 90 100
DLSERPKAKY ILVSAITPTP LGEGKTTTTV GLGQAFSHIG KRATIAIRQA
110 120 130 140 150
SMGPAFGIKG GAAGGGYSQV VPMERLNLHL TGDLHAVTEA HNMLAAMIDN
160 170 180 190 200
HLYHGNGLGI EPHSISWRRV MDVNDRSLRN IVIGLGARTD GVPRQSGFDI
210 220 230 240 250
TAASEVMAIL ALASSLEDLR ERLGRIVIGH NREGNPVSAE DVRGAGAMAV
260 270 280 290 300
ILKEAIKPNL MQTLEGTPAL VHAGPFGNIA TGNSSVVADL IGIRTADYLI
310 320 330 340 350
TEAGFGADMG AERFFNIKCR ISGLEPDAAV VVATVRALKA HSGRYQIKAG
360 370 380 390 400
APLPEELLEE NPQDVLAGAE NLKKQIENIK LHGVPAVVAI NAFPTDHPSE
410 420 430 440 450
HKAIEEAAKE VGARCAVCRH FTEGGKGAVE LARALEETIE ENERERRRGG
460 470 480 490 500
GGSFRFLYPL EMPLKQKIET IAREVYGAEG VEYDAEALRA LEGFERAGFG
510 520 530 540 550
RLPVCLAKTH LSLSSDPALK GAPRGWKLSV REVRASVGAG FIYPICGQMR
560 570
TMPGLSAHPA AERIDLDGEG NVVGLF
Length:576
Mass (Da):61,554
Last modified:July 11, 2006 - v1
Checksum:i5DDF656C8B90F936
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA. Translation: ABG03734.1.
RefSeqiWP_011563752.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG03734; ABG03734; Rxyl_0766.
KEGGirxy:Rxyl_0766.
PATRICi23368336. VBIRubXyl52678_0781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA. Translation: ABG03734.1.
RefSeqiWP_011563752.1. NC_008148.1.

3D structure databases

ProteinModelPortaliQ1AXZ4.
SMRiQ1AXZ4. Positions 7-574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266117.Rxyl_0766.

Proteomic databases

PRIDEiQ1AXZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABG03734; ABG03734; Rxyl_0766.
KEGGirxy:Rxyl_0766.
PATRICi23368336. VBIRubXyl52678_0781.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciRXYL266117:GH8O-774-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiFTHS1_RUBXD
AccessioniPrimary (citable) accession number: Q1AXZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: July 22, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.