Q1AXB9 (Q1AXB9_RUBXD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
EC=6.3.2.6 HAMAP MF_00137

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137
Ordered Locus Names:	Rxyl_0993

Organism

Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]

Taxonomic identifier

266117 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Rubrobacteridae › Rubrobacterales › Rubrobacterineae › Rubrobacteraceae › Rubrobacter

Protein attributes

Sequence length	237 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137 SAAS SAAS018236
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137 SAAS SAAS018236
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137 RuleBase RU004193

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137 SAAS SAAS018236
Ligand	ATP-binding HAMAP MF_00137 SAAS SAAS018236 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 SAAS SAAS018236 EMBL ABG03959.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q1AXB9 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: BA5B333BA42F7C43	FASTA	237	26,938
	10 20 30 40 50 60 MKRTLLYEGK AKQVFETGEE GVLLHRYKDE ATAFNARKRG SWAGKGRANA SISAAVFAYL 70 80 90 100 110 120 ERRGIPTHFI EQVDEVTLKT RRLRMLPVEI IVRNLAAGSL ARLLGYEEGR PLKAPVVELC 130 140 150 160 170 180 YKNDALGDPM LNWYHFRELG LTDEELRACE EFGLRVNEAL RPFFEERGMV LVDFKIEVGR 190 200 210 220 230 DAGGSLVLAD EISPDTCRLW DKETGQRLDK DRFRRDLGGV EEAYEEVLRR VTGEGVS

References

[1]

"Complete sequence of Rubrobacter xylanophilus DSM 9941." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 9941 / NBRC 16129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000386 Genomic DNA. Translation: ABG03959.1.
RefSeq	YP_643771.1. NC_008148.1.
3D structure databases
ProteinModelPortal	Q1AXB9.
SMR	Q1AXB9. Positions 1-234.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1AXB9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4116211.
GenomeReviews	Gene locus Rxyl_0993 in contig CP000386_GR.
KEGG	rxy:Rxyl_0993.
NMPDR	fig|266117.6.peg.910.
PATRIC	23368820. VBIRubXyl52678_1020.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0152.
HOGENOM	HBG306070.
OMA	YKDDALG.
PhylomeDB	Q1AXB9.
Enzyme and pathway databases
BioCyc	RXYL266117:RXYL_0993-MONOMER.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q1AXB9_RUBXD

Accession

Primary (citable) accession number: Q1AXB9

Entry history

Integrated into UniProtKB/TrEMBL:	July 11, 2006
Last sequence update:	July 11, 2006
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)