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Protein

Proline--tRNA ligase

Gene

proS

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

Catalytic activityi

ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:G1G6P-1109-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
Alternative name(s):
Prolyl-tRNA synthetaseUniRule annotation
Short name:
ProRSUniRule annotation
Gene namesi
Name:proSUniRule annotation
Ordered Locus Names:Rxyl_1087
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteriaRubrobacteralesRubrobacteraceaeRubrobacter
Proteomesi
  • UP000006637 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002884141 – 476Proline--tRNA ligaseAdd BLAST476

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266117.Rxyl_1087

Structurei

3D structure databases

ProteinModelPortaliQ1AX25
SMRiQ1AX25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

Sequence similaritiesi

Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R1M Bacteria
COG0442 LUCA
HOGENOMiHOG000167538
KOiK01881
OMAiEVYWVTH
OrthoDBiPOG091H07N9

Family and domain databases

CDDicd00778 ProRS_core_arch_euk, 1 hit
Gene3Di3.30.110.30, 1 hit
3.40.50.800, 1 hit
HAMAPiMF_01571 Pro_tRNA_synth_type3, 1 hit
InterProiView protein in InterPro
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR002316 Pro-tRNA-ligase_IIa
IPR004499 Pro-tRNA-ligase_IIa_arc-type
IPR016061 Pro-tRNA_ligase_II_C
IPR017449 Pro-tRNA_synth_II
IPR033721 ProRS_core_arch_euk
PfamiView protein in Pfam
PF03129 HGTP_anticodon, 1 hit
PF09180 ProRS-C_1, 1 hit
PF00587 tRNA-synt_2b, 1 hit
PRINTSiPR01046 TRNASYNTHPRO
SMARTiView protein in SMART
SM00946 ProRS-C_1, 1 hit
SUPFAMiSSF64586 SSF64586, 1 hit
TIGRFAMsiTIGR00408 proS_fam_I, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Q1AX25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEAVERLTK KSEDSSRWYL ELVRMAKLAD YGPVRGTFAI RPYGFAIWER
60 70 80 90 100
IQADLDARFK ATGHVNAYFP LLIPESYLTK EAEHVEGFAP ECAWVTVGGD
110 120 130 140 150
DELEERLAIR PTSESIICDF YRKWIHSYRD LPVLINQWCN VLRWEMVTRP
160 170 180 190 200
FLRTAEFLWQ EGHTVHATAE EAREEALRML NVYRDCFYEV LAIPVLTGMK
210 220 230 240 250
SPSERFAGAV ETFTCEGLMG DGRALQAATS HDLGQNFARA FDITFLDENQ
260 270 280 290 300
ERVHPYQTSW GFSTRTIGAL ILVHGDDRGL RLPPKLAPTQ AVVVPIWRGK
310 320 330 340 350
NKGEVRREAE ALHRELAEAG LRAEADLDEE HSPGWKFNEH ELRGVPVRVE
360 370 380 390 400
LGPKDIEKGQ AVLVRRDTGE KEFVGRGAAA RRLVELMDEI QQNMLRQAEA
410 420 430 440 450
FRDENTRRAE TYEEFKEIIE EKRGFVVAPW DGTEETEQRI KEETKATIRL
460 470
LPFEREEGKD LVSGRPGKTA VFARAY
Length:476
Mass (Da):54,544
Last modified:July 11, 2006 - v1
Checksum:iFF54D8996514A556
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA Translation: ABG04053.1
RefSeqiWP_011564071.1, NC_008148.1

Genome annotation databases

EnsemblBacteriaiABG04053; ABG04053; Rxyl_1087
KEGGirxy:Rxyl_1087

Similar proteinsi

Entry informationi

Entry nameiSYP_RUBXD
AccessioniPrimary (citable) accession number: Q1AX25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health