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Q1AX25

- SYP_RUBXD

UniProt

Q1AX25 - SYP_RUBXD

Protein

Proline--tRNA ligase

Gene

proS

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).UniRule annotation

    Catalytic activityi

    ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. proline-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. prolyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRXYL266117:GH8O-1104-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proline--tRNA ligaseUniRule annotation (EC:6.1.1.15UniRule annotation)
    Alternative name(s):
    Prolyl-tRNA synthetaseUniRule annotation
    Short name:
    ProRSUniRule annotation
    Gene namesi
    Name:proSUniRule annotation
    Ordered Locus Names:Rxyl_1087
    OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
    Taxonomic identifieri266117 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
    ProteomesiUP000006637: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Proline--tRNA ligasePRO_0000288414Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi266117.Rxyl_1087.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1AX25.
    SMRiQ1AX25. Positions 6-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.UniRule annotation

    Sequence similaritiesi

    Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0442.
    HOGENOMiHOG000167538.
    KOiK01881.
    OMAiNDWEIKG.
    OrthoDBiEOG6G7R2R.

    Family and domain databases

    Gene3Di3.30.110.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPiMF_01571. Pro_tRNA_synth_type3.
    InterProiIPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR002316. Pro-tRNA-ligase_IIa.
    IPR004499. Pro-tRNA-ligase_IIa_arc-type.
    IPR016061. Pro-tRNA_ligase_II_C.
    IPR017449. Pro-tRNA_synth_II.
    [Graphical view]
    PANTHERiPTHR11451:SF6. PTHR11451:SF6. 1 hit.
    PfamiPF03129. HGTP_anticodon. 1 hit.
    PF09180. ProRS-C_1. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view]
    PRINTSiPR01046. TRNASYNTHPRO.
    SMARTiSM00946. ProRS-C_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52954. SSF52954. 1 hit.
    SSF64586. SSF64586. 1 hit.
    TIGRFAMsiTIGR00408. proS_fam_I. 1 hit.
    PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1AX25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEAVERLTK KSEDSSRWYL ELVRMAKLAD YGPVRGTFAI RPYGFAIWER    50
    IQADLDARFK ATGHVNAYFP LLIPESYLTK EAEHVEGFAP ECAWVTVGGD 100
    DELEERLAIR PTSESIICDF YRKWIHSYRD LPVLINQWCN VLRWEMVTRP 150
    FLRTAEFLWQ EGHTVHATAE EAREEALRML NVYRDCFYEV LAIPVLTGMK 200
    SPSERFAGAV ETFTCEGLMG DGRALQAATS HDLGQNFARA FDITFLDENQ 250
    ERVHPYQTSW GFSTRTIGAL ILVHGDDRGL RLPPKLAPTQ AVVVPIWRGK 300
    NKGEVRREAE ALHRELAEAG LRAEADLDEE HSPGWKFNEH ELRGVPVRVE 350
    LGPKDIEKGQ AVLVRRDTGE KEFVGRGAAA RRLVELMDEI QQNMLRQAEA 400
    FRDENTRRAE TYEEFKEIIE EKRGFVVAPW DGTEETEQRI KEETKATIRL 450
    LPFEREEGKD LVSGRPGKTA VFARAY 476
    Length:476
    Mass (Da):54,544
    Last modified:July 11, 2006 - v1
    Checksum:iFF54D8996514A556
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000386 Genomic DNA. Translation: ABG04053.1.
    RefSeqiYP_643865.1. NC_008148.1.

    Genome annotation databases

    EnsemblBacteriaiABG04053; ABG04053; Rxyl_1087.
    GeneIDi4116675.
    KEGGirxy:Rxyl_1087.
    PATRICi23369020. VBIRubXyl52678_1115.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000386 Genomic DNA. Translation: ABG04053.1 .
    RefSeqi YP_643865.1. NC_008148.1.

    3D structure databases

    ProteinModelPortali Q1AX25.
    SMRi Q1AX25. Positions 6-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266117.Rxyl_1087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG04053 ; ABG04053 ; Rxyl_1087 .
    GeneIDi 4116675.
    KEGGi rxy:Rxyl_1087.
    PATRICi 23369020. VBIRubXyl52678_1115.

    Phylogenomic databases

    eggNOGi COG0442.
    HOGENOMi HOG000167538.
    KOi K01881.
    OMAi NDWEIKG.
    OrthoDBi EOG6G7R2R.

    Enzyme and pathway databases

    BioCyci RXYL266117:GH8O-1104-MONOMER.

    Family and domain databases

    Gene3Di 3.30.110.30. 1 hit.
    3.40.50.800. 1 hit.
    HAMAPi MF_01571. Pro_tRNA_synth_type3.
    InterProi IPR002314. aa-tRNA-synt_IIb_cons-dom.
    IPR006195. aa-tRNA-synth_II.
    IPR004154. Anticodon-bd.
    IPR002316. Pro-tRNA-ligase_IIa.
    IPR004499. Pro-tRNA-ligase_IIa_arc-type.
    IPR016061. Pro-tRNA_ligase_II_C.
    IPR017449. Pro-tRNA_synth_II.
    [Graphical view ]
    PANTHERi PTHR11451:SF6. PTHR11451:SF6. 1 hit.
    Pfami PF03129. HGTP_anticodon. 1 hit.
    PF09180. ProRS-C_1. 1 hit.
    PF00587. tRNA-synt_2b. 1 hit.
    [Graphical view ]
    PRINTSi PR01046. TRNASYNTHPRO.
    SMARTi SM00946. ProRS-C_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52954. SSF52954. 1 hit.
    SSF64586. SSF64586. 1 hit.
    TIGRFAMsi TIGR00408. proS_fam_I. 1 hit.
    PROSITEi PS50862. AA_TRNA_LIGASE_II. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 9941 / NBRC 16129.

    Entry informationi

    Entry nameiSYP_RUBXD
    AccessioniPrimary (citable) accession number: Q1AX25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3