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Q1AWH4

- MDH_RUBXD

UniProt

Q1AWH4 - MDH_RUBXD

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901SubstrateUniRule annotation
Binding sitei96 – 961SubstrateUniRule annotation
Binding sitei103 – 1031NADUniRule annotation
Binding sitei110 – 1101NADUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Binding sitei160 – 1601SubstrateUniRule annotation
Active sitei185 – 1851Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 157NADUniRule annotation
Nucleotide bindingi127 – 1293NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-1308-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Rxyl_1290
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Malate dehydrogenasePRO_0000292375Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266117.Rxyl_1290.

Structurei

3D structure databases

ProteinModelPortaliQ1AWH4.
SMRiQ1AWH4. Positions 5-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000220953.
KOiK00024.
OMAiAFSQECI.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1AWH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKTVTVTGA AGAIGYAILF RIASGQMLGP DQKLRLKLLE IEPALKAAEG
60 70 80 90 100
TAMELYDCAF PLLEAVDITA DPKEAFDGAN VCLLIGARPR QRGMERADLL
110 120 130 140 150
EANGQIFKPQ GRAINDHAAD DVRVLVVGNP ANTNCLIAMN NAPDVPRERF
160 170 180 190 200
SAMTRLDENR AVSMLAQKLG VGVEDVRDLV VWGNHSPTMF PDLFNARVKG
210 220 230 240 250
QRAVDLVEME WYENEYIPRV GKRGAEIIEA RGASSAASAA NAAIDHVRDW
260 270 280 290 300
MLGADSLHSM AVASSGQYGV EEGLVSSFPV RLPGGGEYEI PEGLEVGDFA
310 320
RSKLEITIGE LKEERDAVRK LGLIG
Length:325
Mass (Da):35,044
Last modified:July 11, 2006 - v1
Checksum:iEE303E16E0FC0DCC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA. Translation: ABG04254.1.
RefSeqiWP_011564271.1. NC_008148.1.
YP_644066.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG04254; ABG04254; Rxyl_1290.
GeneIDi4116953.
KEGGirxy:Rxyl_1290.
PATRICi23369438. VBIRubXyl52678_1324.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA. Translation: ABG04254.1 .
RefSeqi WP_011564271.1. NC_008148.1.
YP_644066.1. NC_008148.1.

3D structure databases

ProteinModelPortali Q1AWH4.
SMRi Q1AWH4. Positions 5-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266117.Rxyl_1290.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG04254 ; ABG04254 ; Rxyl_1290 .
GeneIDi 4116953.
KEGGi rxy:Rxyl_1290.
PATRICi 23369438. VBIRubXyl52678_1324.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000220953.
KOi K00024.
OMAi AFSQECI.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci RXYL266117:GH8O-1308-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiMDH_RUBXD
AccessioniPrimary (citable) accession number: Q1AWH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 11, 2006
Last modified: November 26, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3