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Q1AWE0

- RUVB_RUBXD

UniProt

Q1AWE0 - RUVB_RUBXD

Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

    Catalytic activityi

    ATP + H2O = ADP + phosphate.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi81 – 888ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. four-way junction helicase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-HAMAP
    2. DNA repair Source: UniProtKB-HAMAP
    3. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRXYL266117:GH8O-1348-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
    Gene namesi
    Name:ruvBUniRule annotation
    Ordered Locus Names:Rxyl_1324
    OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
    Taxonomic identifieri266117 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
    ProteomesiUP000006637: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Holliday junction ATP-dependent DNA helicase RuvBPRO_0000322838Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a complex with RuvA.UniRule annotation

    Protein-protein interaction databases

    STRINGi266117.Rxyl_1324.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1AWE0.
    SMRiQ1AWE0. Positions 42-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2255.
    HOGENOMiHOG000218623.
    KOiK03551.
    OMAiDYAEVKH.
    OrthoDBiEOG6SR93S.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00016. DNA_helic_RuvB.
    InterProiIPR003593. AAA+_ATPase.
    IPR004605. DNA_helicase_Holl-junc_RuvB.
    IPR008823. DNA_helicase_Holl-junc_RuvB_C.
    IPR008824. DNA_helicase_Holl-junc_RuvB_N.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF05491. RuvB_C. 1 hit.
    PF05496. RuvB_N. 1 hit.
    [Graphical view]
    ProDomiPD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00635. ruvB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1AWE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEMDDFTVR RGEREDITGA AGPPEERPLD PAAFEEDDEP TLRPRTLDEF    50
    VGQERLKENL RIFVEAAKQR GEPLDHMLLA GPPGLGKTSL CRILAAEMGV 100
    QLHPTSGPSL ERAGDMAAIL TSLEEGDFLF IDEIHRLNRQ IEEVLYPAME 150
    DFAIDIVLGQ GPSARTIRMD LPRFTLVGAT TRTGLMTKPL LDRFGFSARL 200
    DYYEPHELEK IVVRNARILG VPITEGGARQ LARRSRGTPR VANRLLKRVR 250
    DYAQVVGDGT IDEETANAAL EMQGVDHLGL DRTDREYLSL IIEKFDGGPV 300
    GVGTLSVALG EARDTVEDVY EPYLLQSGLI QRTSRGRVAT RHAYAHLGFP 350
    VRDGG 355
    Length:355
    Mass (Da):39,339
    Last modified:July 11, 2006 - v1
    Checksum:iA0CF64A5074EC4DF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000386 Genomic DNA. Translation: ABG04288.1.
    RefSeqiWP_011564305.1. NC_008148.1.
    YP_644100.1. NC_008148.1.

    Genome annotation databases

    EnsemblBacteriaiABG04288; ABG04288; Rxyl_1324.
    GeneIDi4115991.
    KEGGirxy:Rxyl_1324.
    PATRICi23369524. VBIRubXyl52678_1361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000386 Genomic DNA. Translation: ABG04288.1 .
    RefSeqi WP_011564305.1. NC_008148.1.
    YP_644100.1. NC_008148.1.

    3D structure databases

    ProteinModelPortali Q1AWE0.
    SMRi Q1AWE0. Positions 42-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266117.Rxyl_1324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG04288 ; ABG04288 ; Rxyl_1324 .
    GeneIDi 4115991.
    KEGGi rxy:Rxyl_1324.
    PATRICi 23369524. VBIRubXyl52678_1361.

    Phylogenomic databases

    eggNOGi COG2255.
    HOGENOMi HOG000218623.
    KOi K03551.
    OMAi DYAEVKH.
    OrthoDBi EOG6SR93S.

    Enzyme and pathway databases

    BioCyci RXYL266117:GH8O-1348-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00016. DNA_helic_RuvB.
    InterProi IPR003593. AAA+_ATPase.
    IPR004605. DNA_helicase_Holl-junc_RuvB.
    IPR008823. DNA_helicase_Holl-junc_RuvB_C.
    IPR008824. DNA_helicase_Holl-junc_RuvB_N.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF05491. RuvB_C. 1 hit.
    PF05496. RuvB_N. 1 hit.
    [Graphical view ]
    ProDomi PD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00635. ruvB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 9941 / NBRC 16129.

    Entry informationi

    Entry nameiRUVB_RUBXD
    AccessioniPrimary (citable) accession number: Q1AWE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3