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Q1AWE0

- RUVB_RUBXD

UniProt

Q1AWE0 - RUVB_RUBXD

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Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi81 – 888ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. four-way junction helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
  3. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-1348-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvBUniRule annotation
Ordered Locus Names:Rxyl_1324
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Holliday junction ATP-dependent DNA helicase RuvBPRO_0000322838Add
BLAST

Interactioni

Subunit structurei

Forms a complex with RuvA.UniRule annotation

Protein-protein interaction databases

STRINGi266117.Rxyl_1324.

Structurei

3D structure databases

ProteinModelPortaliQ1AWE0.
SMRiQ1AWE0. Positions 42-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2255.
HOGENOMiHOG000218623.
KOiK03551.
OMAiDYAEVKH.
OrthoDBiEOG6SR93S.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00016. DNA_helic_RuvB.
InterProiIPR003593. AAA+_ATPase.
IPR004605. DNA_helicase_Holl-junc_RuvB.
IPR008823. DNA_helicase_Holl-junc_RuvB_C.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05491. RuvB_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view]
ProDomiPD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00635. ruvB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1AWE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEMDDFTVR RGEREDITGA AGPPEERPLD PAAFEEDDEP TLRPRTLDEF
60 70 80 90 100
VGQERLKENL RIFVEAAKQR GEPLDHMLLA GPPGLGKTSL CRILAAEMGV
110 120 130 140 150
QLHPTSGPSL ERAGDMAAIL TSLEEGDFLF IDEIHRLNRQ IEEVLYPAME
160 170 180 190 200
DFAIDIVLGQ GPSARTIRMD LPRFTLVGAT TRTGLMTKPL LDRFGFSARL
210 220 230 240 250
DYYEPHELEK IVVRNARILG VPITEGGARQ LARRSRGTPR VANRLLKRVR
260 270 280 290 300
DYAQVVGDGT IDEETANAAL EMQGVDHLGL DRTDREYLSL IIEKFDGGPV
310 320 330 340 350
GVGTLSVALG EARDTVEDVY EPYLLQSGLI QRTSRGRVAT RHAYAHLGFP

VRDGG
Length:355
Mass (Da):39,339
Last modified:July 11, 2006 - v1
Checksum:iA0CF64A5074EC4DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG04288.1.
RefSeqiWP_011564305.1. NC_008148.1.
YP_644100.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG04288; ABG04288; Rxyl_1324.
GeneIDi4115991.
KEGGirxy:Rxyl_1324.
PATRICi23369524. VBIRubXyl52678_1361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG04288.1 .
RefSeqi WP_011564305.1. NC_008148.1.
YP_644100.1. NC_008148.1.

3D structure databases

ProteinModelPortali Q1AWE0.
SMRi Q1AWE0. Positions 42-350.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266117.Rxyl_1324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG04288 ; ABG04288 ; Rxyl_1324 .
GeneIDi 4115991.
KEGGi rxy:Rxyl_1324.
PATRICi 23369524. VBIRubXyl52678_1361.

Phylogenomic databases

eggNOGi COG2255.
HOGENOMi HOG000218623.
KOi K03551.
OMAi DYAEVKH.
OrthoDBi EOG6SR93S.

Enzyme and pathway databases

BioCyci RXYL266117:GH8O-1348-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00016. DNA_helic_RuvB.
InterProi IPR003593. AAA+_ATPase.
IPR004605. DNA_helicase_Holl-junc_RuvB.
IPR008823. DNA_helicase_Holl-junc_RuvB_C.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF05491. RuvB_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view ]
ProDomi PD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00635. ruvB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiRUVB_RUBXD
AccessioniPrimary (citable) accession number: Q1AWE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 11, 2006
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3