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Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi81 – 88ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:G1G6P-1353-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvBUniRule annotation
Ordered Locus Names:Rxyl_1324
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteriaRubrobacteralesRubrobacteraceaeRubrobacter
Proteomesi
  • UP000006637 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003228381 – 355Holliday junction ATP-dependent DNA helicase RuvBAdd BLAST355

Interactioni

Subunit structurei

Forms a complex with RuvA.UniRule annotation

Protein-protein interaction databases

STRINGi266117.Rxyl_1324

Structurei

3D structure databases

ProteinModelPortaliQ1AWE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKJ Bacteria
COG2255 LUCA
HOGENOMiHOG000218623
KOiK03551
OMAiDEIHRMS
OrthoDBiPOG091H00GH

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00016 DNA_helic_RuvB, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR004605 DNA_helicase_Holl-junc_RuvB
IPR008823 DNA_helicase_Holl-junc_RuvB_C
IPR027417 P-loop_NTPase
IPR008824 RuvB_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR42848 PTHR42848, 1 hit
PfamiView protein in Pfam
PF05491 RuvB_C, 1 hit
PF05496 RuvB_N, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005323 DNA_helicase_Holl-junc_RuvB_C, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00635 ruvB, 1 hit

Sequencei

Sequence statusi: Complete.

Q1AWE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEMDDFTVR RGEREDITGA AGPPEERPLD PAAFEEDDEP TLRPRTLDEF
60 70 80 90 100
VGQERLKENL RIFVEAAKQR GEPLDHMLLA GPPGLGKTSL CRILAAEMGV
110 120 130 140 150
QLHPTSGPSL ERAGDMAAIL TSLEEGDFLF IDEIHRLNRQ IEEVLYPAME
160 170 180 190 200
DFAIDIVLGQ GPSARTIRMD LPRFTLVGAT TRTGLMTKPL LDRFGFSARL
210 220 230 240 250
DYYEPHELEK IVVRNARILG VPITEGGARQ LARRSRGTPR VANRLLKRVR
260 270 280 290 300
DYAQVVGDGT IDEETANAAL EMQGVDHLGL DRTDREYLSL IIEKFDGGPV
310 320 330 340 350
GVGTLSVALG EARDTVEDVY EPYLLQSGLI QRTSRGRVAT RHAYAHLGFP

VRDGG
Length:355
Mass (Da):39,339
Last modified:July 11, 2006 - v1
Checksum:iA0CF64A5074EC4DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA Translation: ABG04288.1
RefSeqiWP_011564305.1, NC_008148.1

Genome annotation databases

EnsemblBacteriaiABG04288; ABG04288; Rxyl_1324
KEGGirxy:Rxyl_1324

Similar proteinsi

Entry informationi

Entry nameiRUVB_RUBXD
AccessioniPrimary (citable) accession number: Q1AWE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 11, 2006
Last modified: February 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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