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Q1AWE0 (RUVB_RUBXD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Holliday junction ATP-dependent DNA helicase RuvB

EC=3.6.4.12
Gene names
Name:ruvB
Ordered Locus Names:Rxyl_1324
OrganismRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]
Taxonomic identifier266117 [NCBI]
Taxonomic lineageBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing By similarity. HAMAP-Rule MF_00016

Catalytic activity

ATP + H2O = ADP + phosphate. HAMAP-Rule MF_00016

Subunit structure

Forms a complex with RuvA By similarity. HAMAP-Rule MF_00016

Sequence similarities

Belongs to the RuvB family.

Ontologies

Keywords
   Biological processDNA damage
DNA recombination
DNA repair
SOS response
   LigandATP-binding
Nucleotide-binding
   Molecular functionHelicase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA recombination

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

SOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

DNA binding

Inferred from electronic annotation. Source: InterPro

four-way junction helicase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Holliday junction ATP-dependent DNA helicase RuvB HAMAP-Rule MF_00016
PRO_0000322838

Regions

Nucleotide binding81 – 888ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q1AWE0 [UniParc].

Last modified July 11, 2006. Version 1.
Checksum: A0CF64A5074EC4DF

FASTA35539,339
        10         20         30         40         50         60 
MEEMDDFTVR RGEREDITGA AGPPEERPLD PAAFEEDDEP TLRPRTLDEF VGQERLKENL 

        70         80         90        100        110        120 
RIFVEAAKQR GEPLDHMLLA GPPGLGKTSL CRILAAEMGV QLHPTSGPSL ERAGDMAAIL 

       130        140        150        160        170        180 
TSLEEGDFLF IDEIHRLNRQ IEEVLYPAME DFAIDIVLGQ GPSARTIRMD LPRFTLVGAT 

       190        200        210        220        230        240 
TRTGLMTKPL LDRFGFSARL DYYEPHELEK IVVRNARILG VPITEGGARQ LARRSRGTPR 

       250        260        270        280        290        300 
VANRLLKRVR DYAQVVGDGT IDEETANAAL EMQGVDHLGL DRTDREYLSL IIEKFDGGPV 

       310        320        330        340        350 
GVGTLSVALG EARDTVEDVY EPYLLQSGLI QRTSRGRVAT RHAYAHLGFP VRDGG 

« Hide

References

[1]"Complete sequence of Rubrobacter xylanophilus DSM 9941."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. expand/collapse author list , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P.
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 9941 / NBRC 16129.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000386 Genomic DNA. Translation: ABG04288.1.
RefSeqYP_644100.1. NC_008148.1.

3D structure databases

ProteinModelPortalQ1AWE0.
SMRQ1AWE0. Positions 42-350.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING266117.Rxyl_1324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABG04288; ABG04288; Rxyl_1324.
GeneID4115991.
KEGGrxy:Rxyl_1324.
PATRIC23369524. VBIRubXyl52678_1361.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2255.
HOGENOMHOG000218623.
KOK03551.
OMANGYLERT.
OrthoDBEOG6SR93S.
ProtClustDBPRK00080.

Enzyme and pathway databases

BioCycRXYL266117:GH8O-1348-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00016. DNA_helic_RuvB.
InterProIPR003593. AAA+_ATPase.
IPR004605. DNA_helicase_Holl-junc_RuvB.
IPR008823. DNA_helicase_Holl-junc_RuvB_C.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF05491. RuvB_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view]
ProDomPD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00635. ruvB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVB_RUBXD
AccessionPrimary (citable) accession number: Q1AWE0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 11, 2006
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families