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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi478MagnesiumUniRule annotation1
Metal bindingi484MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-binding, Transferase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciRXYL266117:G1G6P-1447-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Rxyl_1418
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteriaRubrobacteralesRubrobacteraceaeRubrobacter
Proteomesi
  • UP000006637 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003298221 – 686Polyribonucleotide nucleotidyltransferaseAdd BLAST686

Proteomic databases

PRIDEiQ1AW48

Interactioni

Protein-protein interaction databases

STRINGi266117.Rxyl_1418

Structurei

3D structure databases

ProteinModelPortaliQ1AW48
SMRiQ1AW48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini545 – 604KHUniRule annotationAdd BLAST60
Domaini614 – 684S1 motifUniRule annotationAdd BLAST71

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62 Bacteria
COG1185 LUCA
HOGENOMiHOG000218327
KOiK00962
OMAiRYMHNYN
OrthoDBiPOG091H00M0

Family and domain databases

Gene3Di3.30.1370.10, 1 hit
3.30.230.70, 2 hits
HAMAPiMF_01595 PNPase, 1 hit
InterProiView protein in InterPro
IPR001247 ExoRNase_PH_dom1
IPR015847 ExoRNase_PH_dom2
IPR036345 ExoRNase_PH_dom2_sf
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
IPR012340 NA-bd_OB-fold
IPR012162 PNPase
IPR027408 PNPase/RNase_PH_dom_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR022967 S1_dom
IPR003029 S1_domain
PANTHERiPTHR11252 PTHR11252, 1 hit
PfamiView protein in Pfam
PF00013 KH_1, 1 hit
PF01138 RNase_PH, 2 hits
PF03725 RNase_PH_C, 2 hits
PF00575 S1, 1 hit
PIRSFiPIRSF005499 PNPase, 1 hit
SMARTiView protein in SMART
SM00322 KH, 1 hit
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF54211 SSF54211, 2 hits
SSF54791 SSF54791, 1 hit
SSF55666 SSF55666, 2 hits
TIGRFAMsiTIGR03591 polynuc_phos, 1 hit
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 1 hit
PS50126 S1, 1 hit

Sequencei

Sequence statusi: Complete.

Q1AW48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLEIPVGER AIVLETGKLA RQAGGAVTAR FGDTTVLSTA TRSEEPRPGA
60 70 80 90 100
TFLPLSVDIE ERMSSAGKIP GGFLKREGKP SEKAILTARL TDRPIRPLFP
110 120 130 140 150
KDYYYEVQVI GTVLVADQEN PYDVVSMVGA SAALALSDIP FGGPIGAVRV
160 170 180 190 200
GRHPDGGFIL NPTYQQLEES DLDIVVAGTK EAITMVEAGA REVTEDVVVE
210 220 230 240 250
ALEVAQGVIR EQAEAIERWA AEHGEEKQPF EEPGENPFVE ELRGAYLERI
260 270 280 290 300
KEGLISTDRR ARHEAIDLLK EELVEGRSEE EVPLVLDALA QLQKEAFRKL
310 320 330 340 350
YLEDRKRTDL RAFDEIRPTT AEAHVLPRVH GTGLFTRGET QVLSSLALAD
360 370 380 390 400
LGLVQRLDTL EPQTTKRYMH HYYFPPYSTG ETGRLGPPRR REIGHGALAE
410 420 430 440 450
RALLPVIPSE EEFPYAIRII SEVLESNGSS SMASVCGSTL ALMDGGVPIK
460 470 480 490 500
APVAGVAMGL VKEGDDYVIL TDIQGLEDHM GDMDFKVAGT RDGITALQMD
510 520 530 540 550
MKITGVSAEL LKEALEQARR GRLQILDIMR EEIAEPRPEI SDHAPRVEVI
560 570 580 590 600
QIPTDKIGLL IGPGGKTINA LQDEYGVNIS VENDGTVYVA GVEGMSVKAA
610 620 630 640 650
VSAIKGMTKE VEAGDIYVGK VVKTTNFGAF VELTPGRDGL LHISRLAPGK
660 670 680
QRVRRVEDVL NEGDVVKVRV LEIDKQNRIS LEMVED
Length:686
Mass (Da):74,939
Last modified:July 11, 2006 - v1
Checksum:i4189C396F4CABDD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA Translation: ABG04380.1
RefSeqiWP_011564397.1, NC_008148.1

Genome annotation databases

EnsemblBacteriaiABG04380; ABG04380; Rxyl_1418
KEGGirxy:Rxyl_1418

Similar proteinsi

Entry informationi

Entry nameiPNP_RUBXD
AccessioniPrimary (citable) accession number: Q1AW48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health