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Q1AW48

- PNP_RUBXD

UniProt

Q1AW48 - PNP_RUBXD

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi478 – 4781MagnesiumUniRule annotation
Metal bindingi484 – 4841MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-1443-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:Rxyl_1418
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Polyribonucleotide nucleotidyltransferasePRO_0000329822Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266117.Rxyl_1418.

Structurei

3D structure databases

ProteinModelPortaliQ1AW48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini545 – 60460KHUniRule annotationAdd
BLAST
Domaini614 – 68471S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218327.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1AW48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLEIPVGER AIVLETGKLA RQAGGAVTAR FGDTTVLSTA TRSEEPRPGA
60 70 80 90 100
TFLPLSVDIE ERMSSAGKIP GGFLKREGKP SEKAILTARL TDRPIRPLFP
110 120 130 140 150
KDYYYEVQVI GTVLVADQEN PYDVVSMVGA SAALALSDIP FGGPIGAVRV
160 170 180 190 200
GRHPDGGFIL NPTYQQLEES DLDIVVAGTK EAITMVEAGA REVTEDVVVE
210 220 230 240 250
ALEVAQGVIR EQAEAIERWA AEHGEEKQPF EEPGENPFVE ELRGAYLERI
260 270 280 290 300
KEGLISTDRR ARHEAIDLLK EELVEGRSEE EVPLVLDALA QLQKEAFRKL
310 320 330 340 350
YLEDRKRTDL RAFDEIRPTT AEAHVLPRVH GTGLFTRGET QVLSSLALAD
360 370 380 390 400
LGLVQRLDTL EPQTTKRYMH HYYFPPYSTG ETGRLGPPRR REIGHGALAE
410 420 430 440 450
RALLPVIPSE EEFPYAIRII SEVLESNGSS SMASVCGSTL ALMDGGVPIK
460 470 480 490 500
APVAGVAMGL VKEGDDYVIL TDIQGLEDHM GDMDFKVAGT RDGITALQMD
510 520 530 540 550
MKITGVSAEL LKEALEQARR GRLQILDIMR EEIAEPRPEI SDHAPRVEVI
560 570 580 590 600
QIPTDKIGLL IGPGGKTINA LQDEYGVNIS VENDGTVYVA GVEGMSVKAA
610 620 630 640 650
VSAIKGMTKE VEAGDIYVGK VVKTTNFGAF VELTPGRDGL LHISRLAPGK
660 670 680
QRVRRVEDVL NEGDVVKVRV LEIDKQNRIS LEMVED
Length:686
Mass (Da):74,939
Last modified:July 11, 2006 - v1
Checksum:i4189C396F4CABDD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA. Translation: ABG04380.1.
RefSeqiYP_644192.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG04380; ABG04380; Rxyl_1418.
GeneIDi4117274.
KEGGirxy:Rxyl_1418.
PATRICi23369714. VBIRubXyl52678_1456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000386 Genomic DNA. Translation: ABG04380.1 .
RefSeqi YP_644192.1. NC_008148.1.

3D structure databases

ProteinModelPortali Q1AW48.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266117.Rxyl_1418.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG04380 ; ABG04380 ; Rxyl_1418 .
GeneIDi 4117274.
KEGGi rxy:Rxyl_1418.
PATRICi 23369714. VBIRubXyl52678_1456.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218327.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci RXYL266117:GH8O-1443-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiPNP_RUBXD
AccessioniPrimary (citable) accession number: Q1AW48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 11, 2006
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3