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Q1AVP8

- FTHS2_RUBXD

UniProt

Q1AVP8 - FTHS2_RUBXD

Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 768ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRXYL266117:GH8O-1598-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetase 2UniRule annotation
    Short name:
    FHS 2UniRule annotation
    Short name:
    FTHFS 2UniRule annotation
    Gene namesi
    Name:fhs2UniRule annotation
    Ordered Locus Names:Rxyl_1568
    OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
    Taxonomic identifieri266117 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
    ProteomesiUP000006637: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 576576Formate--tetrahydrofolate ligase 2PRO_0000293055Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi266117.Rxyl_1568.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1AVP8.
    SMRiQ1AVP8. Positions 7-574.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1AVP8-1 [UniParc]FASTAAdd to Basket

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    MGEALSNLEI ARGAKLLPIE EVGRSMGLRE ERHLEPYGRH VAKVDLCAIE    50
    DLSERPKAKY ILVSAITPTP LGEGKTTTTV GLGQAFSHIG KRATIAIRQA 100
    SMGPAFGIKG GAAGGGYSQV VPMERLNLHL TGDLHAVTEA HNMLAAMIDN 150
    HLYHGNGLGI EPHSISWRRV MDVNDRSLRN IVIGLGARTD GVPRQSGFDI 200
    TAASEVMAIL ALASSLEDLR ERLGRIVIGH DREGNPVSAE DVRGAGAMAV 250
    ILKEAIKPNL MQTLEGTPAL VHAGPFGNIA TGNSSVVADL IGIRTADYLI 300
    TEAGFGADMG AERFFNIKCR ISGLEPDAAV VVATVRALKA HSGRYQIKAG 350
    APLPEELLEE NPQDVLAGAE NLKKQIENIK LHGVPAVVAI NAFPTDHPSE 400
    HKAIEEAAKE VGARCAVCRH FTEGGKGAVE LARALEETIE ENERERRRGG 450
    GGSFRFLYPL EMPLKQKIET IAREVYGAEG VEYDAEALRA LEGFERAGFG 500
    RLPVCLAKTH LSLSSDPALK GAPRGWKLSV REVRASVGAG FIYPICGQMR 550
    TMPGLSAHPA AERIDLDGEG NVVGLF 576
    Length:576
    Mass (Da):61,555
    Last modified:July 11, 2006 - v1
    Checksum:i60FF8BCC619CD358
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000386 Genomic DNA. Translation: ABG04530.1.
    RefSeqiWP_011564547.1. NC_008148.1.
    YP_644342.1. NC_008148.1.

    Genome annotation databases

    EnsemblBacteriaiABG04530; ABG04530; Rxyl_1568.
    GeneIDi4116450.
    KEGGirxy:Rxyl_1568.
    PATRICi23370014. VBIRubXyl52678_1601.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000386 Genomic DNA. Translation: ABG04530.1 .
    RefSeqi WP_011564547.1. NC_008148.1.
    YP_644342.1. NC_008148.1.

    3D structure databases

    ProteinModelPortali Q1AVP8.
    SMRi Q1AVP8. Positions 7-574.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 266117.Rxyl_1568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABG04530 ; ABG04530 ; Rxyl_1568 .
    GeneIDi 4116450.
    KEGGi rxy:Rxyl_1568.
    PATRICi 23370014. VBIRubXyl52678_1601.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci RXYL266117:GH8O-1598-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 9941 / NBRC 16129.

    Entry informationi

    Entry nameiFTHS2_RUBXD
    AccessioniPrimary (citable) accession number: Q1AVP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3