Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1AVP8

- FTHS2_RUBXD

UniProt

Q1AVP8 - FTHS2_RUBXD

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase 2

Gene

fhs2

Organism
Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 768ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRXYL266117:GH8O-1598-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase 2UniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetase 2UniRule annotation
Short name:
FHS 2UniRule annotation
Short name:
FTHFS 2UniRule annotation
Gene namesi
Name:fhs2UniRule annotation
Ordered Locus Names:Rxyl_1568
OrganismiRubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
Taxonomic identifieri266117 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaRubrobacteridaeRubrobacteralesRubrobacterineaeRubrobacteraceaeRubrobacter
ProteomesiUP000006637: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Formate--tetrahydrofolate ligase 2PRO_0000293055Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi266117.Rxyl_1568.

Structurei

3D structure databases

ProteinModelPortaliQ1AVP8.
SMRiQ1AVP8. Positions 7-574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1AVP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEALSNLEI ARGAKLLPIE EVGRSMGLRE ERHLEPYGRH VAKVDLCAIE
60 70 80 90 100
DLSERPKAKY ILVSAITPTP LGEGKTTTTV GLGQAFSHIG KRATIAIRQA
110 120 130 140 150
SMGPAFGIKG GAAGGGYSQV VPMERLNLHL TGDLHAVTEA HNMLAAMIDN
160 170 180 190 200
HLYHGNGLGI EPHSISWRRV MDVNDRSLRN IVIGLGARTD GVPRQSGFDI
210 220 230 240 250
TAASEVMAIL ALASSLEDLR ERLGRIVIGH DREGNPVSAE DVRGAGAMAV
260 270 280 290 300
ILKEAIKPNL MQTLEGTPAL VHAGPFGNIA TGNSSVVADL IGIRTADYLI
310 320 330 340 350
TEAGFGADMG AERFFNIKCR ISGLEPDAAV VVATVRALKA HSGRYQIKAG
360 370 380 390 400
APLPEELLEE NPQDVLAGAE NLKKQIENIK LHGVPAVVAI NAFPTDHPSE
410 420 430 440 450
HKAIEEAAKE VGARCAVCRH FTEGGKGAVE LARALEETIE ENERERRRGG
460 470 480 490 500
GGSFRFLYPL EMPLKQKIET IAREVYGAEG VEYDAEALRA LEGFERAGFG
510 520 530 540 550
RLPVCLAKTH LSLSSDPALK GAPRGWKLSV REVRASVGAG FIYPICGQMR
560 570
TMPGLSAHPA AERIDLDGEG NVVGLF
Length:576
Mass (Da):61,555
Last modified:July 11, 2006 - v1
Checksum:i60FF8BCC619CD358
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG04530.1.
RefSeqiWP_011564547.1. NC_008148.1.
YP_644342.1. NC_008148.1.

Genome annotation databases

EnsemblBacteriaiABG04530; ABG04530; Rxyl_1568.
GeneIDi4116450.
KEGGirxy:Rxyl_1568.
PATRICi23370014. VBIRubXyl52678_1601.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000386 Genomic DNA. Translation: ABG04530.1 .
RefSeqi WP_011564547.1. NC_008148.1.
YP_644342.1. NC_008148.1.

3D structure databases

ProteinModelPortali Q1AVP8.
SMRi Q1AVP8. Positions 7-574.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 266117.Rxyl_1568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABG04530 ; ABG04530 ; Rxyl_1568 .
GeneIDi 4116450.
KEGGi rxy:Rxyl_1568.
PATRICi 23370014. VBIRubXyl52678_1601.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci RXYL266117:GH8O-1598-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 9941 / NBRC 16129.

Entry informationi

Entry nameiFTHS2_RUBXD
AccessioniPrimary (citable) accession number: Q1AVP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 11, 2006
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3