Q1AVP8 (FTHS2_RUBXD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase 2
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase 2
Short name=FHS 2
Short name=FTHFS 2

Gene names

Name:	fhs2
Ordered Locus Names:	Rxyl_1568

Organism

Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]

Taxonomic identifier

266117 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Rubrobacteridae › Rubrobacterales › Rubrobacterineae › Rubrobacteraceae › Rubrobacter

Protein attributes

Sequence length	576 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 576	576	Formate--tetrahydrofolate ligase 2 HAMAP MF_01543		PRO_0000293055
Regions
	Nucleotide binding	69 – 76	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1AVP8 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: 60FF8BCC619CD358	FASTA	576	61,555
	10 20 30 40 50 60 MGEALSNLEI ARGAKLLPIE EVGRSMGLRE ERHLEPYGRH VAKVDLCAIE DLSERPKAKY 70 80 90 100 110 120 ILVSAITPTP LGEGKTTTTV GLGQAFSHIG KRATIAIRQA SMGPAFGIKG GAAGGGYSQV 130 140 150 160 170 180 VPMERLNLHL TGDLHAVTEA HNMLAAMIDN HLYHGNGLGI EPHSISWRRV MDVNDRSLRN 190 200 210 220 230 240 IVIGLGARTD GVPRQSGFDI TAASEVMAIL ALASSLEDLR ERLGRIVIGH DREGNPVSAE 250 260 270 280 290 300 DVRGAGAMAV ILKEAIKPNL MQTLEGTPAL VHAGPFGNIA TGNSSVVADL IGIRTADYLI 310 320 330 340 350 360 TEAGFGADMG AERFFNIKCR ISGLEPDAAV VVATVRALKA HSGRYQIKAG APLPEELLEE 370 380 390 400 410 420 NPQDVLAGAE NLKKQIENIK LHGVPAVVAI NAFPTDHPSE HKAIEEAAKE VGARCAVCRH 430 440 450 460 470 480 FTEGGKGAVE LARALEETIE ENERERRRGG GGSFRFLYPL EMPLKQKIET IAREVYGAEG 490 500 510 520 530 540 VEYDAEALRA LEGFERAGFG RLPVCLAKTH LSLSSDPALK GAPRGWKLSV REVRASVGAG 550 560 570 FIYPICGQMR TMPGLSAHPA AERIDLDGEG NVVGLF

References

[1]

"Complete sequence of Rubrobacter xylanophilus DSM 9941." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 9941 / NBRC 16129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000386 Genomic DNA. Translation: ABG04530.1.
RefSeq	YP_644342.1. NC_008148.1.
3D structure databases
ProteinModelPortal	Q1AVP8.
SMR	Q1AVP8. Positions 7-574.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1AVP8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4116450.
GenomeReviews	Gene locus Rxyl_1568 in contig CP000386_GR.
KEGG	rxy:Rxyl_1568.
NMPDR	fig|266117.6.peg.1435.
PATRIC	23370014. VBIRubXyl52678_1601.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HBG677721.
OMA	NHLHHGN.
PhylomeDB	Q1AVP8.
ProtClustDB	PRK13505.
Enzyme and pathway databases
BioCyc	RXYL266117:RXYL_1568-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS2_RUBXD

Accession

Primary (citable) accession number: Q1AVP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program