Q1AV95 (IOLG_RUBXD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase
EC=1.1.1.18

Alternative name(s):
Myo-inositol 2-dehydrogenase
Short name=MI 2-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	Rxyl_1723

Organism

Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129) [Complete proteome] [HAMAP]

Taxonomic identifier

266117 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Rubrobacteridae › Rubrobacterales › Rubrobacterineae › Rubrobacteraceae › Rubrobacter

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose) By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Inositol 2-dehydrogenase HAMAP MF_01671		PRO_0000352589

Sequences

	Sequence		Length	Mass (Da)
	Q1AV95 [UniParc]. Last modified July 11, 2006. Version 1. Checksum: BB152928FF64412E	FASTA	347	37,298
	10 20 30 40 50 60 MRGDSERIAV GVVGTGGMGG MHAENLHFRV PGARLVAVAD LDTRRAGGVA ERSGAEVFED 70 80 90 100 110 120 GFDLIRSDRV EAVVIASPDP THAPLVLECL KNEKPVLCEK PLADSADAAR KVVEAEVELG 130 140 150 160 170 180 RKLVQVGFMR RYDPQHVAVK EAVASGAVGA PVLFRGWHRN ADIEPGITSE WVVINATIHD 190 200 210 220 230 240 IDSARWFIEE EIEEVYVRGM NTAPKLGANV WDLQLIQFTT AGGRLGSIET NVVSGYGYEV 250 260 270 280 290 300 GVEIVGERGT VQVPPLSGAI VRRGFAASQR IEDGWLARFH AAYVIEMQGW VGALLRGEAP 310 320 330 340 AGPDAWDGYA SLVVADACIA SLRSGAPQKV ETLEPPTLYR RDVEVTG

References

[1]

"Complete sequence of Rubrobacter xylanophilus DSM 9941." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Munk A.C., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J. , Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A., da Costa M.S., Rainey F.A., Empadinhas N., Jolivet E., Battista J.R., Richardson P. Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 9941 / NBRC 16129.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000386 Genomic DNA. Translation: ABG04683.1.
RefSeq	YP_644495.1. NC_008148.1.
3D structure databases
ProteinModelPortal	Q1AV95.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1AV95.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4116623.
GenomeReviews	Gene locus Rxyl_1723 in contig CP000386_GR.
KEGG	rxy:Rxyl_1723.
NMPDR	fig|266117.6.peg.1572.
PATRIC	23370318. VBIRubXyl52678_1750.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0673.
HOGENOM	HBG612336.
OMA	SHDSTHA.
Enzyme and pathway databases
BioCyc	RXYL266117:RXYL_1723-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_RUBXD

Accession

Primary (citable) accession number: Q1AV95

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	July 11, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program